October 2011

Mahatma Gandhi University, one of the four affiliating universities in Kerala, is the premier educational institution that strives to fulfil the higher educational needs of the people of Central Kerala. Set on the sprawling 110-acre campus called Priyadarshini Hills at Athirampuzha, 13 kms off Kottayam, the University also has seven satellite campuses in parts of Kottayam and the neighbouring districts.

About Authors:
Sukanto Paul, Krishan R Bhadu
Department of Quality Assurance, School of Pharmaceutical Sciences,
Jaipur National University,
Jagatpura, Jaipur-302025,
Rajasthan, India.

ABSTRACT
A validated reverse phase high performance liquid chromatography method has been developed for the simultaneous determination of Tirofiban hydrochloride in pure and marketed formulation. Chromatography was carried out on a BDS Hypersil C18 (4.6 mm × 250 mm, 5 μm) using Buffer: Acetonitrile in the ratio of 80:20 (v/v) as the mobile phase at a flow rate of 1.5 mL/min and eluents were monitored at 274 nm using UV detector at ambient temperature.  The average retention time of Tirofiban was found to be 9.124 min. The method was validated for linearity, precision, accuracy, specificity, robustness and solution stability. The calibration curve was linear (R²≥0.9999) over the range of 12.5-75 μg/mL.Limit of detection (LOD) and Limit of quantitation (LOQ) were 0.11 μg/mL and 0.33 μg/mL respectively. This method can be successfully employed for the quantitative analysis of Tirofiban hydrochloride in bulk drugs and formulations.

About Authors:
Garg Pushpendra, Nanda Arun
Department of Pharmaceutical Sciences
Maharshi Dayanand University, Rohtak-124001
Haryana, India.

ABSTRACT
The objective of the present study was to improve the dissolution rate of gliclazide, a poorly water soluble (BCS class-II) drug by solid dispersion technique using a water soluble carrier, poloxamer 407. The solid dispersions were prepared by fusion method using different concentrations of carrier and the prepared systems showed an enhancement in dissolution. Solid dispersions were characterized with Differential scanning calorimetry, X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy and dissolution analysis. The study revealed that enhanced dissolution of gliclazide from solid dispersion was due to a decrease in crystallinity of drug and also due to dissolution of gliclazide in molten form of solid dispersion. In conclusion preparation of gliclazide dispersion with meltable hydrophilic polymer could be a promising approach to improve the dissolution rate.

About Author: G. Anand Rao*, V. Venu, R. Senthil Selvi, P. Perumal,
Department of Pharmaceutics,
J. K. K. Nattraja College of Pharmacy,
Komarapalayam - 638 183, Namakkal (D.T),
Tamil Nadu, India

Abstract
The main objective of the present work was to develop sustained release matrix tablets of Lornoxicam using Hydrophilic polymers viz. Hydroxy propyl methyl cellulose (HPMC K4M, HPMC K10M, HPMC K15M) was developed using wet granulation technique at varying ratios of drug and polymer like 1:1, 1:2 and 1:3 were selected for the study. Micro crystalline cellulose and Lactose was added in this formulation as a function of binder and diluent. Prior to compression, the prepared granules were evaluated for flow and compression characteristics. After evaluation of physical properties of tablet, the in vitro release study was performed in 0.1 N Hcl, pH 1.2 for 2 hrs and in phosphate buffer pH 6.8 up to 12 hrs. The effect of polymer concentration and polymer blend concentration were studied. Dissolution data was analyzed by Korsmeyer- Peppas law expression. It was observed that matrix tablets contained polymer HPMC K10M was successfully sustained the release of drug up to 12 hrs. Among all the formulations, formulation F9 which contains 1:3 ratios of drug and polymer release the drug which follows Zero order kinetics via, swelling, diffusion and erosion. Stability studies (40±2oc/75±5%RH) for three months indicated that Lornoxicam was stable in the matrix tablets. The FTIR study revealed that there was no chemical interaction between drug and excipients.

About Author: Manoj Dupati, Shiva Kumar, Sharadamma K. C. and Radhakrishna P. M.
Provimi Animal Nutrition India Pvt Limited,
Yelahanka New Town, Bangalore – 560 106,
Karnataka, India

Plants have provided human beings for all needs in terms of shelter, clothing, food, ?avours and medicines. In particular plants have formed the basis of sophisticated traditional medicine systems like Ayurvedic, Unani, and Chinese amongst others. These systems of medicine have given rise to some important drugs which are being used in modern medicine too. This article highlights and provides an overview of the classes of molecules present in plants having specific biological activity and finds use as feed additives ensuring better health and productivity of live stock.