Research Articles

9 September 2014

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF SILDENAFIL CITRATE AND DAPOXETINE HYDROCHLORIDE IN THEIR COMBINED DOSAGE FORMULATION

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20 August 2014

FORMULATION EVALUATION AND OPTIMIZATION OF MEBENDAZOLE COLON TARGETED SUSTAIN RELEASE PELLETS BY EXTRUSION SPHERONIZATION

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ABOUT AUTHORS:
Raval Aniket*, Chauhan Sachin P., Sheth A.K, Shah Nirmal, Aundhia Chintan
Department of Pharmacy, Sumandeep Vidyapeeth University,
At & Po Pipariya, Ta. - Waghodia, Dist. Vadodara, Gujarat, India
aniket_raval2006@yahoo.co.in

ABSTRACT:
The aim of present investigation is to formulate evaluate and optimization of colon targeted pellets bearing mebendazole, benzimidazole derivative with broad spectrum of anthelminthic activity. It is highly effective against adult and larval stages of ascaris lumbricoids, hook worms and indicated for the treatment of nematode infestation. Pellets were prepared by extrusion spheronization process using microcrystalline cellulose as spheronizing aid, natural polysaccharide pectin as binders in three different percentages i.e 5%, 10% and 15% and glycerine as plasticizer. Further study was carried out to select the natural polysaccharide for formulation of colon targeted pellets i.e. Pectine, Xanthan gum and Guar gum. The formulation were prepared with optimized constant process parameters i.e. Percentage LOD 10%, Spheronization time 3 minutes and Speed of spheronization 700-1200 rpm. Prepared A1 – A9 batches were then evaluated by their micromeritic properties like tapped density, carr’s index, hausner, S ratio, angle of repose and characterized by microscopic study, % yield, hardness, friability, % assay and dissolution study was carried out and compared with marketed formulation by statistical analysis similarity factor (f₂). The batch A5 is having 10% pectin, 18% MCC and 20% mebendazole shows (22.20±2.05) % carr’s index, (1.22±0.04) hausner’s ratio, (26.65±1.15) angle of repose, (88.2±2.36) % yield, (3.96±0.46) hardness, (0.23±0.03) % friability (88.47±3.26) % assay and (99.81±3.80) % drug release after 10 hours. Pellets equivalent to 300mg of mebendazole were then filled in capsules and capsules coated with 12.5% w/v Eudragit S 100 using optimized 4- 5 ml/min spray rate, 15 rpm pan speed and 40±5°C coating inlet temperature and then optimized for % weight gain in four different trials. W2 batch having 10% weight gain were then evaluated by % cumulative drug release, disintegration test in 0.1 N HCl shows (99.73±3.34) % CDR, intact after 12 hours. The pellets of batch A5 and the enteric coated capsule with 10 % weight gain were packed in aluminum pouch and charged for accelerated stability studies at (40°C±2°C) and (75%±5%) RH for 1 month in a stability chamber shows no change in the dissolution profile at (40°C±2°C) and (75%±5%) RH storage condition.
11 July 2014

TOXICOLOGICAL SCREENING OF ‘GOWRI CHINTHAMANI CHENDOORAM'- A SIDDHA METALLIC PREPARATION

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ABOUT AUTHORS:
Shanmugapriya.P¹, Thamodharan.S¹, M.Ramamurthy², V.C. Jiji Mol³, M. Nijavizhi³
¹Department of Nanjunool, National instistute of siddha, Chennai, Tamil Nadu, India
²Assistant medical officer, Salavakkam
³PG scholars, National institute of siddha, Chennai, Tamil Nadu, India
drjijivijay@gmail.com

ABSTRACT
'Gowri chinthamani chendooram', a siddha drug was evaluated for its acute and chronic toxicity studies in wistar albino rats with reference to haematological, bio-chemical and histopathological studies. Acute study revealed a maximum tolerated does of 640 mg/100 gm b.w chronic toxicity study revealed a minimum toxic effect at adoes level of 40 mg/100 gm b.w. Where in, the changes observed were non-specific. The toxicity findings were dose specific, which had tissue damage in higher dosages.
12 June 2014

EVALUATION OF ANTI-DEPRESSANT ACTIVITY OF HYDRO ALCOHOLIC EXTRACT OF TRITICUM AESTIVUM

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ABOUT AUTHORS:
K.Charan
A.U.College of Pharmaceutical Sciences,
Waltair, Visakhapatnam, Andhra Pradesh, India.
charan.karumuri@gmail.com

ABSTRACT
The present study was designed to screen anti-depressant activity of Hydro alcoholic extract of Triticum Aestivum using Chronic models (14 day study) of Tail suspension test (TST) and Forced Swim Test (FST) in Swiss Albino rats. Wheat grass were collected and authenticated. Extraction of dried wheat grass was carried out using a Soxhlet apparatus to obtain its Hydro alcoholic extract. The extract of Triticum Aestivum showed the significant anti-depressant activity comparable to the standard drug. The oral administration of Triticum Aestivum extract at doses 200 mg/kg & 400 mg/kg respectively as compared to the control treated group showed an anti-depressant activity comparable to that of standard drug.
The anti-depressant effects of Triticum Aestivum extract seem to be mainly associated with the activation of dopaminergic system and possess potential anti-depressant activity.
15 May 2014

FORMULATION AND EVALUATION OF SUSTAINED RELEASED PELLETS OF TRAMADOL HCl

ABOUT AUTHORS:
*S. Patel, M. Patel
Department of Pharma. Technology,
L.J.Institute of Pharmacy, Ahmedabad, Gujarat, India
shivanipatel090390@gmail.com

ABSTRACT:
The present research concerns the formulation and evaluation of sustained release pellets filled capsule of opioid analgesic, Tramadol HCl. Developmentof sustained release dosage form is to maintain therapeutic blood levels of the drug for extended period of time. Sustained release formulation provides uniform concentration at absorption site, maintains plasma concentration within a therapeutic range, reduces the dosage frequency and minimizes the side effects (nausea) associated with drug by avoiding dose dumping effect. Oral sustained release pellet formulations of Tramadol HCl were prepared using extrusion-spheronization technique. Pellets provide specific advantages of smoother plasma concentration profile and gradual absorption than tablet. Various polymers like Hydroxy propyl methyl cellulose (HPMC K100M), Carbopol, Xanthan gum, Ethyl cellulose and Eudragit RSPO were used to screen the best polymer combination through preliminary formulations. HPMC K100M and EC were screened and their concentrations were optimized using 3² full factorial design to achieve the aim of sustaining the drug release for 12 hours. Eudragit RSPO was used to coat the pellets. The prepared pellets were studied for different flow properties and drug release studies.
21 April 2014

PREPARATION AND EVALUATION OF MATRIX TABLETS CONTAINING AMBROXOL HYDROCHLORIDE

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ABOUT AUTHORS:
Soma Vinisha*, Sajida Akhtari Begum, Nikhat Tabassum, Soma Anusha
Department of pharmaceutical science,
Bharat Institution of Techology, Hyderabad, India
choti.reddy@gmail.com

ABSTRACT
Purpose: This study aimed to formulate Ambroxol hydrochloride SR matrix tablets using xanthan gum (natural polymer) and to elucidate the release kinetics of Ambroxol hydrochloride from xanthan gum-matrices. Methods: controlled release matrix tablets of ambroxol hydrochloride, a mucolytic expectorant were prepared by wet granulation method using xanthan gum as natural hydrophilic polymer in three different ratios (Drug : Polymer 1:1(F-1), 1:1.5(F-2), 1:2(F-3)). The prepared granules of three different formulations were evaluated for angle of repose, bulk density (BD), tapped density (TD) and compressibility index (CI), hausners ratio. The prepared tablets were tested for physical parameters like weight variation, hardness, friability, content of active ingredient and In-vitro drug release studies. Results: The results obtained were within the prescribed limits. The release of ambroxol from the matrix tablets was sustained up to 12hrs. The cumulative percentage of drug release was decrease with increase in polymer concentration. Among the three formulations F-3 gave the release profile close to the commercially available marketed sample of ambroxol Hcl (A-MS).The results indicate that the drug release from the matrix tablets followed Zero order kinetics. The dissolution data was fitted to Korsmeyer equation which is used to describe the drug release behaviour from polymeric systems. All the formulations showed diffusion co-efficient value (n) greater than 0.43 but less than 0.85 after fitting to the Korsmeyer equation. So, it indicates Non-Fickian transport mechanism. Therefore the drug release is by diffusion and erosion mechanism. Conclusion: Matrix tablets of Ambroxol Hydrochloride using xanthan gum prepared by wet granulation method were found to be good in appearance. The drug-polymer ratio was found to influence the release of drug from the formulations. Formulation F-3 i.e. (1:2 drug: polymer) exhibited the similar In-vitro drug release rates as that of the marketed sample.
27 March 2014

FORMULATION, DEVELOPMENT AND EVALUATION OF ANTI-IMPLANTATION ACTIVITY OF INTRAUTERINE SYSTEM OF CENTCHROMAN (SAHELI) USING WISTAR ALBINO RATS

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21 March 2014

PHYTOCHEMICAL SCREENING & EVALUATION OF ANTIMICROBIAL ACTIVITY OF GLYCYRRHIZA GLABRA LINN

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7 March 2014

EVALUATION OF ANTI DIARRHEAL POTENTIAL OF CINNAMON LEAVES

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2 March 2014

IN-VITRO SCREENING OF DHATURA INOXIA FOR ITS ANTI-MALARIAL ACTIVITY AGAINST P. FALCIPARUM

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ABOUT AUTHORS:
S.O. Pratap^1,2, Ruchi Gaur³, R.Stephan⁴, J.L bhatt³, C.R. Pillai¹, Usha Devi¹
¹Department of Parasitology, Malaria Research Center, New Delhi
²Department of Biotechnology, SR Group of Institutions, Jhansi, UP
³School of Life Science, ITM University Gwalior, MP
⁴Department of Botany, Government P.G. College Ariyalur, Tamilnadu, India
dixitshivom@gmail.com

ABSTRACT
The natural products are important source of biologically active compounds having potential for developing a novel malaria drug. Malaria is one of the most important infectious vector born parasitic disease caused by Coccidian protozoan parasite of genus Plasmodium carried out by mosquito, invade red blood cells. Malaria is thousand times more complex than any disease. In the current study, a natural ingredient of herb; Dhatura Inoxia is analyzed, for its anti-malarial activity by preparing crude extract of water and ethanol, analyzed on schizont stage of plasmodial life cycle against two Chloroquine strains: sensitive and resistant of Plasmodium falciparum isolates. The results revealed that IC₅₀ values of crude water extract was recorded as; 71± 1.41µg/ml and 105±7.07 while as the ethanol crude extract produced IC₅₀ concentrates: 52±3.53 µg/ml and 59.5± 70 µg/ml against sensitive and resistant P. f. isolates, respectively. The results showed that this herb plant possess significant antiplasmodial activity in terms of IC₅₀as recorded in this study.

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