Review Articles

11 November 2014

ROLE OF BCG IN TREATMENT OF BLADDER CANCER

{ DOWNLOAD AS PDF }

ABOUT AUTHOR
Abhishek Singhal
Department of Pharmacology,
Smt. Kashibai Navale College of Pharmacy, Kondhwa (Bk.),
Pune, Maharastra, India
*abhishekspharma@gmail.com

ABSTRACT
Aim: This review is written to describe the role of immunotherapy in cancer treatment.
Annually, 13,000 deaths result from bladder cancer. Since the first report of intravesical use of BCG in 1976, investigators try to understand the working mechanism of BCG as an antitumour modality. Arbitrarily, BCG therapy consists of a single course of six weekly intravesical instillations. Bacillus Calmette-Gue´rin, an attenuated strain of Mycobacterium bovis, was developed by Calmette and Gue´rin with the intention to generate a vaccine against tuberculosis. Extension of BCG treatment (maintenance immunotherapy) is used to increase efficacy.
Results of various experiments describe that after instillation in the bladder, BCG accumulates near the bladder wall and is internalised and processed by professional antigen-presenting cells (APCs) and (high-grade) tumour cells. Then BCG antigens are presented to CD4+ T cells. Then local synthesis of a particular set of cytokines or cell-mediated immune response. NK cells may be involve in tumour cell killing.
9 November 2014

DEADLY BUT CURABLE: A REVIEW ON POTENTIAL TREATMENTS FOR EBOLA HAEMORRHAGIC FEVER

{ DOWNLOAD AS PDF }

ABOUT AUTHOR:
Bushra Shamim
Department of Pharmaceutics,
Faculty of Pharmacy,
Hamdard University, New Delhi, India
bushrashamim21@gmail.com

ABSTRACT
This is a review article on potential treatments for Ebola virus disease, also known as Ebola haemorrhagic fever. Ebola fever has emerged as one of the deadliest known forms of hemorrhagic fever since discovered in 1976. Transmission among humans occurs through the exchange of blood and body secretions. The Ebola virus causes an acute, serious illness which is often fatal if untreated. In this article experimental treatments like blood, immunological and drug therapies are discussed that are under development
27 October 2014

EFFECT OF MAGNETIC FIELD ON CANCER CELLS

{ DOWNLOAD AS PDF }

ABOUT AUTHORS:
Rajesh Tiwari^1*, Roshan kumar²
¹Chemistry Department, Dr. Ghanshyam Singh Post Graduate College, Varanasi
²SBCBE VIT University, Vellore
*Rajesh.tiwari851@gmail.com

ABSTRACT
In 16^th century physician were of the opinion that magnet can be used for the treatment or eliminate the diseases from the body. Here the reports about the chemical synthesis, protection, functionalization and application of magnetic nanoparticles of nano structured system. Research of magnetic nanoparticles for targeted drug delivery system and function of magnetic nanoparticles on particular area are reviewed. Use of magnetic nanoparticles for cancer diagnosis has been advancing day by day. This review is related to the multifunctional use of magnetic nanoparticles probes and their use in bio imaging and nano medicine.
26 October 2014

MULTIPLE SCLEROSIS: OVERVIEW ON SIMPLE CURE

{ DOWNLOAD AS PDF }

ABOUT AUTHORS:
Duvvuru Ashok Kumar¹*, Languluri Reddenna²
¹Department of Pharm-D, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India
²Department of Pharmacy Practice, Rajiv Gandhi Institute of Medical Sciences, Kadapa, Andhra Pradesh, India
ashok.alex11@gmail.com

ABSTRACT
MS is the most common inflammatory-demyelinating disease of the central nervous system (CNS). MS is estimated to affect 400,000 persons in the United States and 2 million people worldwide. Women are affected twice as frequently as men, between the ages of 20 and 40. The etiology of MS is still unknown, but according to current data the disease develops in genetically susceptible individuals and may require additional environmental triggers. In this paper, we present the insight on simple cure for multiple sclerosis.
22 October 2014

HERBAL ANTI HYPERTENSION DRUGS

{ DOWNLOAD AS PDF }

ABOUT AUTHORS:
Asha Kesari*, Pushpa Kumari Mahto, Shankheswari Kishan, Suranjeeta Singh
Department of Pharmaceutics,
Kanak Manjari Institute of Pharmaceutical Sciences,
Rourkela, Odisha
ashakeshri@yahoo.co.in

ABSTRACT
Hypertension or high blood pressure is a chronic medical condition in which the arterial blood pressure is elevated (normal blood pressure is 120/80 mm Hg). High Blood Pressure may lead to heart failure, stroke, coronary heart disease, kidney failure etc and may affect lungs, brain and heart. It is an important global problem and a very good percentage of people all over the world are affected by blood pressure. As there is no definite cure for this condition, hence controlling it is a big challenge. The main focus on BP management is to lower the elevated blood pressure and to prevent or reduce target organ damage. Although various antihypertensive drugs are available, they are usually associated with many sides –effects. The following article deals with the alternative measures used for lowering high blood pressure giving more importance on the various herbal drugs to be used as combination therapy.
13 October 2014

AN OVERVIEW ON MANGIFERA INDICA: IMPORTANCE AND ITS VARIOUS PHARMACOLOGICAL ACTION

{ DOWNLOAD AS PDF }

About Author:
Pallab Kalita
Assam Down Town University,
Institute of Pharmacy, Guwahati, Assam, India
kalitapallab@gmail.com

Abstract
Majority of crude drugs from plant origin are used in Indian system of medicine. Medicinal plants are using as herbal remedies to prevent and cure several ailments differs from community to community. Most studies on the exploitation of mango have been dealing with mango peels, juices and stem bark and mango leaves. Mangifera indica (Anacardiaceae), reported to contain active substances like mangiferin. In ayurveda, one of its uses is clearing digestion and acidity. Mangiferin is a pharmacologically active flavonoids, which having the anti bacterial, antioxidant, anticancer, antidiabetes, hepatoprotective, anti inflammatory activities.
10 October 2014

ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF DIFFERENT TRIAZOLE ANALOGUES

{ DOWNLOAD AS PDF }

ABOUT AUTHOR
Mohammad Asif
Department of Pharmacy, GRD(PG) Institute of Management and Technology,
Dehradun, Uttarakhand, India
aasif321@gmail.com

ABSTRACT
Different heterocyclic analogues were evaluated for their diverse biological activities. The triazole moiety seems to be very small but in the biological profile has attracted the attention of many researchers to explore this skeleton to its multiple potential against several activities. Triazole analogues have a wide range of biological applications including antimicrobial, antimalarial, antitubercular, anti-inflammatory, analgesic, antiepileptic, antiviral, antihypertensive, antianxiety, antidepressant, antihistaminic activities etc. This review provides a brief response of the medicinal chemistry of triazole analogues particulary as analgesic and anti-inflammatory activities.
6 October 2014

DR.SUBHAS MUKHERJEE AND INDIA’S FIRST TEST TUBE BABY

{ DOWNLOAD AS PDF }

ABOUT AUTHOR:
Avlikant J. Dhawale*
RedCross Formulation, Ajanta Pharma, Aurangabad, Maharashtra
Department of Biochemistry, Gramin Science College (Swami Ramanand Tirth Marathwada University), Nanded, Maharashtra, India
*dhawale111@gmail.com

ABSTRACT:
Infertility is the inability of an animal or plant to reproduce by natural means. Many people in the world are facing the problem of infertility altimatlely the problem of saving their generations. Today, modern science chalanged and solved the problem of infertility by developing the technique of Test Tube Baby by using principle of in-vitro fertilization.

Dr. Subhas Mukherjee, first Asian who invented most easy and successful method of producing Test Tube Baby. In Culcutta, West Bengal, on 3rd October 1978, the team announced the birth of World's Second Test Tube baby named as 'Durga' (Kanupriya Agarwal). The announcement came 67 days after the birth of World's First Test Tube Baby named as 'Louise Brown in England by Physiologist Robert G. Edwards who awarded the Nobel Prize for such work in 2010. During his lifetime, Government of West Bengal didn't recognized his work. By the day to day insult from government Dr. Subhas Mukherjee committed to suicide.
5 October 2014

TRANSDERMAL DRUG DELIVERY THROUGH CARRIERS: TRANSFERSOMES

{ DOWNLOAD AS PDF }

ABOUT AUTHOR:
Nirlep kaur
Institute of pharmaceutical sciences,
Kurukshetra University, Kurukshetra, Haryana, India
Nirlep10@gmail.com

ABSTRACT
Delivery of drug through Transdermal route represents a most convenient and novel approach. Transfersomes were found to be more effective as they render controlled release of drug due to depot formation in skin and were more effective in transdermal delivery. Transfersomes are applied to the skin and permeate through the stratum corneum lipid lamellar regions as a result of the hydration and osmotic force in the skin. Transfersomes have been widely used as a novel carrier for transdermal drug delivery. The Transfersomes can be evaluated by in vitro for vesicle shape and size, entrapment efficiency, degree of deformability, number of vesicles per cubic mm. Transfersomes enhances the penetration of most of the low as well as high molecular weight drugs. When tested in artificial systems transfersomes can pass through even tiny pores (100 nm) which are 1500 times smaller. The use of transfersomes carrier results in delivery of high concentration of active agents through the skin, regulated by system composition and their physical characteristics. Thus, this novel technique has got a great potential for overcoming current problems faced by the conventional techniques.

(adsbygoogle = window.adsbygoogle || []).push({});
3 October 2014

A REVIEW ON MEDICINAL PLANTS AFFECTING AMNESIA ON SCOPOLAMINE INDUCED MODEL

{ DOWNLOAD AS PDF }

ABOUT AUTHORS:
Yash Prashar*, N.S Gill, Sahil Kakkar
Rayat Institute of Pharmacy; Railmajra,
District SBS Nagar, Punjab, India
yashprashar@gmail.com

ABSTRACT
Scopolamine a cholinergic antagonist may cause amnesia in human and animal models. Amnesia induced by Scopolamine has been widely used to understand the biochemical and behavioral changes in rodents. This model can be used to describe the therapeutic targets of memory impairment. In this model the Scopolamine decreases the central cholinergic neuronal activity, block muscarinic receptor and induces oxidative stress. Cholinesterase inhibitors (Donepezil, tacrine, galantamine, and rivastigmine are widely used in the treatment of amnesia. These inhibitors showed non-significant effects. Therefore, herbal medicine can be the sources for the treatment of memory loss due to their Antiacethylcholine esterase and antioxidant activities. In this paper introducing the medicinal plants and their components affecting amnesia on the scopolamine induced model are discussed.