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  • ALZHEIMER DISEASE AND CONTRIBUTION OF NANOTECHNOLOGY AND HERBALTRADITIONAL DRUGS IN THE TREATMENT OF ALZHEIMER DISEASE

    About Authors:
    Himani sharma
    B.pharm; mahakal institute of pharmaceutical studies,
    Ujjain (m.p.); rgpv
    shimani53@gmail.com

    ABSTRACT
    Among the several identified types of dementia, Alzheimer's dis­ease (AD) is the most common. In 1906 a German physician, Dr. Alois Alzheimer, specifically identified a collection of brain cell abnormalities as a disease which is a degenerative brain disorder. Today, this degenerative brain disorder bears his name, and when found during an autopsy, these plaques and tangles mean a definite diagnosis of Alzheimer's disease (AD).  This article provides a general idea of some main causes ofAlzheimer's disease, use of various prospects of nanotechnology herbal medicines and intended to explain the therapeutic effectiveness of various herbal medicines in the treatment of Alzheimer disease.

  • A COMPREHENSIVE REVIEW ON TUMARI (TREWIA NUDIFLORA LINN.)

    About Authors:
    N. Balakrishnan*, Mayank Srivastava, Pallavi Tiwari
    Department of Pharmacognosy,
    Technocrats Institute of Technology-Pharmacy,
    Bhopal-462021(MP), India.
    *pharmacobala@gmail.com

    Abstract
    Medicinal plants have main and cheap source of unique phytoconstituents, they are used extensively in the development of new drugs against various diseases and disorders. The 80% of world population especially in the developing countries relies on the traditional system of medicine for primary choice to treat diseases. Trewia nudiflora Linnbelongs to the family Euphorbiaceae and is one of the important medicinal plant in Indian systems of medicine like Ayurveda, Siddha,etc. It is used as stomachic and alterative in flatulence, gout, rheumatism and malignancy especially leukemia and hepato- biliary affections etc.  The decoction of shoots and leaves of Trewia nudiflora is used to treat excessive bile and sputum. The leaves are applied on wounds to heal them with good efficiency. It contains a pyridine alkaloid, N-methyl-5-carboxamide-2-pyridone. Hence,an attempt has been made in this review paper to explore various phytochemical and pharmacological studies carried out on this plant.

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  • REVIEW ARTICLE ON ANTIMICROBIAL ACTIVITY OF THESPESIA POPULNIA SEEDS

    About Author:
    Sharad kumar awasthi

    Shri Ram Institute Of Technology,
    Jabalpur (M.P.) 482002.
    Sharad20n@gmail.com

    ABSTRACT:
    Thespesia populnia seeds were dried and then grinded to obtain fine powder. Ethanolic and aqueous extracts and etheral extract of thespesia seeds were evaluated for antibacterial activity against E.coli, B.subtilis with the comparison control (Ciprofloxacin and Amoxicillin) for bacteria. The extract showed good inhibitory activity on the microbes.

  • PHARMACOGNOSTIC INVESTIGATION OF ELAEOCARPUS GANITRUS Roxb. LEAF AND SEED

    About Authors:
    Awan Bharti
    Department of Pharmacognosy,
    Shri Rawatpura Sarkar Institute of Pharmacy,
    Datia, M.P.
    bhartiawan@gmail.com

    ABSTRACT
    Elaeocarpus ganitrus Roxb. (Family: Elaeocarpaceae) commonly known as Rudraksha. Rudraksha beads, the holy beads scientifically called as Elaeocarpus Ganitrus. It possesses good medicinal value and with religious, medicinal and spiritual significances. Present investigation deals with macroscopic, microscopic. Microscopic studies revealed the presence of cuticle, epidermis, collenchyma, vascular bundle, xylem and phloem, hard endocarp, seeds with membranous seed coat.

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  • EFFECT OF PRUNUS AMYGDALUS (BATSCH) IN DIFFERENT MODELS OF ULCER

    About Authors:
    Devendra Kumar1,Pragya Seth2
    Department of Pharmaceutical technology,
    1Sri Satya Sai collage of Pharmacy Bhopal,
    2Lakshmi Narain College of Pharmacy, Bhopal
    *guptadevendra15@gmail.com

    Abstract
    The present work describes the effect of methanolic extract of Prunus amygdalus (batsch.) on pylorus ligation and Ethanol-induced gastric ulcer models in Wistar rats. The present study provides a strong evidence of antiulcer activity of Prunus amygdalus extract against gastric lesions. The antiulcer activity is recognized by a reduction in acid-secretary parameters like total and free acidity, gastric volume and ulcer score suggesting that acid inhibition accelerates ulcer healing, thereby strengthening of mucosal barrier. In this present study it shows significant protection for Hexosamine in all treated groups in comparison to negative control group. Inthe LPO results it was observed that there was significance level difference in negative control group and all other group that indicates that lipid peroxides enzyme was higher in vehicle treated group. Ulcer score was determined by the counting of spots and severity of damage in stomach part by any moiety such as ethanol. Single drug treatment (200 mg/kg and 400mg/kg of P.A.E.) was effective up to a significant level (P<0.05) in compare to negative control group.Volume of gastric juice indicate the secretions of gastric fluid and it is higher in negative control group and all drug treated group was effective in relation to negative control group in significance level (P <0.05).

  • Opportunity for D.Pharm, B.Pharm, M.Pharm to work as Pharmacist under NRHM for Free Drug Distribution Programme - 866 posts | other posts Data Entry Operator / Support Staff

    There are total 866 health centres. On each healthcare centre, there will be one pharmacist, one data entry operator and one supporting staff recruited.  Pharmacist / Data Entry Operator / Support Staff on contract basis under NRHM for Free Drug Distribution Programme.

  • Zihla Devas Health Department invites applications for Pharmacist

    Zihla Devas Health Department invites applications for various plans from

    Post: Pharmacist Zilha Logistic Manager

  • TARGETING INFLAMMATION TO TREAT DEPRESSION –A NEWER SCIENTIFIC APPROACH: A REVIEW

    About Authors:
    Mr. Satyanand Tyagi*, Patel Chirag J1, Asheesh Singh2
    *President, Tyagi Pharmacy Association & Scientific Writer (pharmacy), Chattarpur, New Delhi, India-110074.
    Prof. Satyanand Tyagi is a life time member of various pharmacy professional bodies like IPA, APTI and IPGA. He has published various research papers and review articles. His academic works include 52 Publications (44 Review Articles and 08 Research Articles of Pharmaceutical, Medicinal and Clinical Importance, published in standard and reputed National and International Pharmacy journals; Out of 52 publications, 11 are International Publications).
    He has published his papers almost in different specialization of Pharmacy field...His research topics of interest are neurodegenerative disorders, diabetes mellitus, cancer, rare genetic disorders,
    psycho-pharmacological agents as well as epilepsy.
    1Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
    2Research Associate, Center for Research and Development, Ipca Laboratories Ltd Ratlam, Madhya Pradesh, India-457114.
    *sntyagi9 @yahoo.com, +91-9871111375 / 9582025220

    ABSTRACT:
    Prior studies have suggested that depressed people with evidence of high inflammation are less likely to respond to traditional treatments for the disorder, including anti-depressant medications and psychotherapy. This study was designed to see whether blocking inflammation would be a useful treatment for either a wide range of people with difficult-to-treat depression or only those with high levels of inflammation. The study employed infliximab, one of the new biologic drugs used to treat autoimmune and inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. A biologic drug copies the effects of substances naturally made by the body's immune system. In this case, the drug was an antibody that blocks tumour necrosis factor (TNF), a key molecule in inflammation that has been shown to be elevated in some depressed individuals. Study participants all had major depression and were moderately resistant to conventional antidepressant treatment. Each participant was assigned either to infliximab or to a non-active placebo treatment. When investigators looked at the results for the group as a whole, no significant differences were found in the improvement of depression symptoms between the drug and placebo groups. However, when the subjects with high inflammation were examined separately, they exhibited a much better response to infliximab than to placebo.

  • INTRODUCTION TO STEM CELL CRYOPRESERVATION – A NEWER PHENOMENON OF ENSURING THE LONGEVITY OF CHILD HEALTH: A CLINICAL REVIEW

    About Authors:
    Mr. Satyanand Tyagi*, Raghvendra1, Amlan Mishra2, Patel Chirag J3, Asheesh Singh4
    *President, Tyagi Pharmacy Association & Scientific Writer (pharmacy), Chattarpur, New Delhi, India-110074.
    Prof. Satyanand Tyagi is a life time member of various pharmacy professional bodies like IPA, APTI and IPGA. He has published various research papers and review articles. His academic works include 51 Publications (43 Review Articles and 08 Research Articles of Pharmaceutical, Medicinal and Clinical Importance, published in standard and reputed National and International Pharmacy journals; Out of 51 publications, 11 are International Publications).
    He has published his papers almost in different specialization of Pharmacy field...His research topics of interest are neurodegenerative disorders, diabetes mellitus, cancer, rare genetic disorders as well as epilepsy.
    1
    Department of Pharmaceutics, Aligarh College of Pharmacy, Aligarh, U.P, India-202001.
    2Department of Pharmacology, Smt. Vidyawati College of Pharmacy, Jhansi, U.P, India-284128.
    3Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
    4Research Associate, Center for Research and Development, Ipca Laboratories Ltd Ratlam, Madhya Pradesh, India-457114.

    *sntyagi9@yahoo.com,
    +91-9871111375 / 9582025220

    ABSTRACT:
    The umbilical blood cord being rich in stem cells needs to be preserved by means of a new technique called cryopreservation. The Process whereby whole tissues or cells are preserved by cooling at very low temperatures is known as Cryopreservation. Stem cell cryopreservation is a relatively new phenomenon; it is one way of ensuring the longevity of child’s health. This is done by banking the baby’s umbilical cord blood affluent with stem cells. Stem cells are important as they can grow into tissues, even organs like the heart or liver. What is more, they have the awesome potential to revamp damaged tissues.

    Till date, over seventy diseases have been successfully treated with the help of stem cell stored in the cord blood. Research on stem cells has, by no means, abated. Scientists realizing their potential and worth are carrying out intensive research on their uses as well as ways preservation. Before preserving stem cells, a biological test is carried out to eschew the possibility of deadly diseases like various types of Hepatitis or HIV. That done, the cord blood cells are now stored by means of the technique under discussion- Cryopreservation. This technique involves adding a cryopreservant that lets the blood freeze gradually. The blood is frozen to sub-zero degree temperatures so that biochemical reactions or any other dangerous biological that could cause cell death may be arrested. Typically, the cells are stored at temperatures as low as -196, – 156, or – 120 degrees centigrade. Freezing stem cells through cryopreservation at such low temperatures is supposed to ensure their longevity. Let it be known, however, that scientists are still divided over the optimum temperatures as well as the efficacy of the cryopreservation technique itself. The aim of present article is to provide in depth knowledge about this technique of preserving stem cells of child i.e. the technique so called “Cryopreservation”. An attempt is also made to focus how this technique ensures the longevity of child’s health.

  • CHARACTERISATION OF MARKER CHROMOSOMES

    About Authors:
    Masani Jigneshkumar Naranbhai
    School Of Science
    Biomedical Technology
    Jiwaji University, Gwalior
    jigneshmasani11@gmail.com

    ABSTRACT
    A supernumerary marker chromosome is an extra structurally abnormal chromosome of unknown origin. Various factors contribute to the difficulty of clarifying the phenotypicrisks of super numerary marker chromosomes (SMC), including differences inthe size, structure, and origin of marker chromosomes.

    All marker chromosomes do not contribute the same risk of recurrence. Therefore characterization of the marker chromosomes is of utmost importance for Genetic Counseling. Different molecular techniques can be used to identify the chromosome material present in the markers. In the present retrospective data analysis of 15,000 karyotypes of all patients referred to the Center of Medical Genetics, Sir Ganga Ram Hospital from 1998 to 2012. For constitution chromosome abnormality detection, we found fifteen (0.01%) patients had presence of the SMC. Of these fifteen, eight markers had been characterized after FISH was introduced in the year 2004.  This contributed to personalized Genetic Counseling and help for future pregnancies.

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