Madhya Pradesh

About Author:
*Seema Singh¹, Sandeep Kumar Singh^2
1Department of Pharmacy, Northern India Engineering College, Lucknow (U.P.) India
²Department of Pharmaceuticals Sciences, Dr. H S Guar University Sagar (M.P.), India
*seema_b.pharm@rediffmail.com

Abstract:
Present study is aimed to delineate a co-relation between status of anti-oxidant enzymes, lipid peroxidation products with severity of Pregnancy Induced Hypertension (PIH) and cervical dysplasia. The study has been done on 66 patients out of whom 14 were normal pregnancy and had no disease, 31 patients of PIH and 21 patients having cervical dysplasia gr. I-II. Enzymatic activities of Superoxide dismutase (SOD), Catalase (CAT), vitamin C and vitamin E and malonaldehyde levels (MDA, a marker of lipid peroxides) were assessed spectrophotometrically. Mean Malonaldehyde level in PIH patients (8.48 ± 0.96) & Cervical patients (8.31 ± 1.25) in comparison to normal patients (4.88 ± 1.035), the rise was found highly significant (p < 0.001). The enzymatic activity of antioxidants such as Superoxide dismutase, Catalase, vitamin C and vitamin E was decreased in PIH patients & cervical dysplasia patients as compared to normal patients (p < 0.001). The difference was statistically significant (p < 0.001) whereas the same was observed in cervical dysplasia patients. No statistically difference was observed between the levels of antioxidants of PIH patients & cervical dysplasia patients (p < 0.01). Co-relation of Hb with MDA level showed that aneamic patients have raised level of MDA as compared to non aneamic patients. There is positive oxidant/antioxidant balance which may aggravate free radical damage during pre eclampsia and eclampsia with cervical dysplasia.

Pharmacy is a dynamic, growing, and increasingly diverse profession, one which creates an excitement because there are so many opportunities for service. The secret in the future will be to identify and take advantage of these opportunities.

Shoolini University is is located in a thick grove of pine trees, 14 km from Solan with cool summers and pleasant winters, and an ideal destination for academic and research romance. It has adopted research driven model and its strength emanates from Sound Governance and Cultural Heritage. Governing Body is comprised of distinguished academicians, entrepreneurs, professional executives and consultants.