Uttarakhand

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About Authors:
Rahul kumar Singh
M.Pharm (Quality Assurance)
Sr. Officer Quality Assurance at Shreya Life Sciences Pvt. Ltd.,
Roorkee, Uttarakhand
rahulsingh.qa@gmail.com

Abstract
Miglitol, an oral alpha-glucosidase inhibitor, is a desoxynojirimycin derivative that delays the digestion of ingested carbohydrates, thereby resulting in a smaller rise in blood glucose concentration following meals. As a consequence of plasma glucose reduction, miglitol reduce levels of glycosylated hemoglobin in patients with Type II (non-insulin-dependent) diabetes mellitus. Systemic nonenzymatic protein glycosylation, as reflected by levels of glycosylated hemoglobin, is a function of average blood glucose concentration over time. Because its mechanism of action is different, the effect of miglitol to enhance glycemic control is additive to that of sulfonylureas when used in combination. In addition, miglitol diminishes the insulinotropic and weight-increasing effects of sulfonylureas. Miglitol has minor inhibitory activity against lactase and consequently, at the recommended doses, would not be expected to induce lactose intolerance.

About Authors:
Roopesh Sachan*¹, Prof. Satyanand Tyagi², Tarun Parashar¹, Soniya¹, Patel Chirag J*³,Patel Pinkesh³, Rishikesh Gupta^4
1*Department of Pharmaceutics, Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-248007.
²President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
³Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
⁴Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India-284128.
*roopeshsachan@gmail.com, +91-9557469989, 9236167104

ABSTRACT:
Nanoparticle drug-delivery systems are the popular ones as are able to increase the selectivity and stability of therapeutic agents. However reticuloendothelial system (RES) uptake, drug leakage, immunogenicity, hemolytic toxicity, cytotoxicity, hydrophobicity restrict the use of these nanostructures. These shortcomings are overcome by surface engineering the dendrimer such as Polyester dendrimer, Citric acid dendrimer, Arginine dendrimer, Glycodendrimers, PEGylated dendrimers, etc.The field of Dendrimers has recently emerged as the most commercially viable technology of this century because of its wide-ranging potential applications in many fields such as: healthcare, electronics, photonics, biotechnology, engineering products, pharmaceuticals, drug delivery, catalysis, electronic devices, environmental issues and nanotechnologies. Dendrimer as a drug delivery agent is a promising, safe and selective drug delivery option.

About Authors:
Gaurav Singh^*1, Prof. Satyanand Tyagi², Patel Chirag J³, Patel Pinkesh³, Tarun Parashar¹, Soniya^1
1*Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-248007.
²President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
³Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
*gaurav.hipr@gmail.com, +91-8057832184/9236167104

ABSTRACT:
Citrulline is a non-essential amino acid, meaning that the body can manufacture it from other nutrients. Within the body, citrulline is converted to the amino acid L-arginine i.e. citrulline acts as a precursor of amino acid arginine.  Some of the proposed uses of citrulline supplements are based on raising levels of arginine. Citrulline also plays a role in a physiological process called “the urea cycle,” in which toxic ammonia is converted to urea. Citrulline boosts our energy levels by lowering blood lactate concentration. It also enhances the process of elimination of ammonia. Although citrulline is not coded for by DNA directly, several proteins are known to contain citrulline as a result of a posttranslational modification.

About Authors:
Roopesh Sachan^1*, Prof. Satyanand Tyagi², Tarun Parashar¹, Soniya¹, Patel Chirag J³, Patel Pinkesh³, Devesh Kaushik^4
1*Department of Pharmaceutics, Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-248007.
²President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
³Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
⁴Territory Business Manager, Diabetes Division, Abbott Healthcare Private Limited, Okhla, New Delhi, India- 110020.
*roopeshsachan@gmail.com, +91-9557469989, 9236167104

ABSTRACT:
In the world of pharmaceuticals, there is a vital role for robotics to play in the complicated processes of research and development, production, and packaging. Justification for robots ranges from improved worker safety to improved quality. Speeding up the drug discovery process is another benefit of robotics. Drug Production Robotics plays an important role in the manufacture of pharmaceutical drugs because, unlike other industries, pharmaceuticals demand higher speed and accuracy. Devices such as syringes, inhalers, IV bags and diabetes testing kits are made with the help of robotics. There is a great potential for the use of robotics systems in the pharmaceutical industry and pharmaceutical companies are gradually injecting more robotic systems into their operations.

About Authors:
Patel Chirag J^*1, Pinkesh Patel¹, Prof. Satyanand Tyagi², Tarun Parashar³, Soniya³, Roopesh Sachan³, Gaurav Singh^3
1Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
²President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
³Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-248007.
*chirag.bangalore@gmail.com, +91-8000501871

ABSTRACT:
Alzheimer's disease is a progressive neurologic disease of the brain leading to the irreversible loss of neurons and the loss of intellectual abilities, including memory and reasoning, which become severe enough to impede social or occupational functioning. Alzheimer's disease is also known as simply Alzheimer’s, and Senile Dementia of the Alzheimer Type (SDAT). During the course of the disease plaques and tangles develop within the structure of the brain. This causes brain cells to die. Patients with Alzheimer's also have a deficiency in the levels of some vital brain chemicals which are involved with the transmission of messages in the brain - neurotransmitters. Alzheimer's disease is the most common form of dementia. The disease gets worse as it develops - it is a progressive disease. There is no current cure for Alzheimer's, although there are ways of slowing down its advance and helping patients with some of the symptoms. Alzheimer's is also a terminal disease - it is incurable and causes death. According the National Institute on Aging, there are estimated to be between 2.4 million and 4.5 million Americans who have Alzheimer's. β-Secretase is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein contains two active site aspartate residues in its extra cellular protein domain and may function as a dimer.

Beta-secretase 1 (BACE1) also known as beta-site APP cleaving enzyme 1 (beta-site amyloid precursor protein cleaving enzyme 1), memapsin-2 (membrane-associated aspartic protease 2), and aspartyl protease 2 (ASP2) is an enzyme that in humans is encoded by the BACE1 gene.Beta-secretase 2 is an enzyme that in humans is encoded by the BACE2 gene. BACE2 is a close homolog of BACE1, a protease known to be an important enzyme involved in the cellular pathways that some believe lead to Alzheimer's disease. The aim of present article is to provide in depth knowledge about probable role of enzymes BACE1 and BACE2 in the management of Alzheimer's disease (AD). An attempt is also made to focus on general overview of Alzheimer’sdisease.

About Authors:
Soniya^1*, Tarun Parashar¹, Satyanand Tyagi², Patel Chirag J³, Rishikesh Gupta^4
1*Department of Pharmaceutics, Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-248002.
²President, Tyagi Pharmacy Association & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
³Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
⁴Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India-284128.
*soniyarani487@gmail.com 08006939832/09999261031

ABSTRACT:
To obviate the problems associated with conventional dosage forms, mouth dissolving tablets have been developed having good hardness, dose uniformity, easy administration, faster disintegration without water and serves as the first choice of dosage form for pediatrics, geriatrics and traveling patients. Mouth dissolving tablets (MDTs) are also known as fast melting tablets, fast disintegrating tablets, fast dissolving/dispersing tablets or melt in mouth tablets.This article gives a brief review of mechanism of action, technologies used now a day for MDTs,Some of promising drug candidates for MDT and evaluation parameters MDTs.Due to wide significance of MDT, this drug delivery system may lead to better patient compliance and ultimate clinical output.