Research News

23 April 2025

A repurposed anti-inflammatory drug may help treat alcohol use disorder and related pain

A preclinical study from scientists at Scripps Research finds that a drug already FDA-approved for treating inflammatory conditions may help reduce both alcohol intake and pain sensitivity two issues that commonly co-occur with alcohol use disorder (AUD).

23 April 2025

Empowering antibodies to better activate the immune system

Antibodies are best known for their ability to latch onto and neutralize bacteria, viruses and other pathogens. But these immune proteins can do more than that: They also activate other components of the immune system, which then go to work to clear an infection. A new study from Scripps Research explores the factors that influence how effectively antibodies engage specific immune cells.

22 April 2025

16 years old team of young researchers developed salt-powered mini fridge for vaccine transport and storage

Team of Young researchers, still in Indian school, developed a portable, electricity-free refrigeration unit using a salt solution to keep vaccines and other temperature-sensitive materials cool. Team consisting of Dhruv Chaudhary, Mithran Ladhania, and Mridul Jain, is known for their work on Thermavault, a device designed to transport vaccines, medicines, and even transplant organs.

21 April 2025

Integrative approach reveals promising candidates for AD risk factors or targets for treatments

A study published in the American Journal of Human Genetics by researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital provides solutions to the pressing need to identify factors that influence Alzheimer’s disease (AD) risk or resistance while providing an avenue to explore potential biological markers and therapeutic targets.

17 April 2025

Microorganisms employ a secret weapon during metabolism

In the global carbon cycle microorganisms have evolved a variety of methods for fixing carbon. Researchers from Bremen and Taiwan have investigated the methods that are utilized at extremely hot, acidic and sulfur-rich hydrothermal vents in shallow waters off the island of Kueishantao, Taiwan.

17 April 2025

Common genetic variants linked to drug-resistant epilepsy

Antiseizure medication is usually prescribed for people with the condition. However, for one in three people with epilepsy around 20 million individuals worldwide, current antiseizure medications are ineffective. This means that people will continue to have seizures despite taking medication – a condition called ‘drug resistance.

14 April 2025

Stevens Researchers Put Glycemic Response Modeling On a Data Diet

In a paper in the Journal of Diabetes Science and Technology, researchers at Stevens Institute of Technology offer a new approach: a data-sparse model capable of accurately predicting individual glycemic responses with no need for blood draws, stool samples, or other unpleasant testing. The key to their approach? Keeping track of what people actually eat.

14 April 2025

FDA clears IND for clinical trial testing switchable CAR-T therapy in patients with autoimmune diseases, without chemotherapy

Calibr-Skaggs Institute for Innovative Medicines, the drug discovery division of Scripps Research, announced today that the FDA has cleared their investigational new drug (IND) application to study switchable chimeric antigen receptor T cell (sCAR-T) therapy in patients with autoimmune conditions. Patient recruitment for the phase 1 trial will begin soon.

10 April 2025

Starch-based microplastics could cause health risks in mice, study finds

Wear and tear on plastic products releases small to nearly invisible plastic particles, which could impact people’s health when consumed or inhaled. To make these particles biodegradable, researchers created plastics from plant starch instead of petroleum.

10 April 2025

Treatment for mitochondrial diseases within reach

Mitochondrial diseases caused by POLG mutations vary in severity. In young children, these diseases can quickly result in brain damage and life-threatening liver problems while others suffer muscle weakness, epilepsy, and organ failure later in childhood. POLG mutations recently received media attention when Prince Frederik of Nassau in Luxembourg died in March 2025 at just 22 years of age.

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A repurposed anti-inflammatory drug may help treat alcohol use disorder and related pain

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