Gwalior

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ABOUT AUTHORS:
S.O. Pratap^1,2, Ruchi Gaur³, R.Stephan⁴, J.L bhatt³, C.R. Pillai¹, Usha Devi^1
1Department of  Parasitology, Malaria Research Center, New Delhi
²Department of  Biotechnology, SR Group of Institutions, Jhansi, UP
³School of Life Science, ITM University Gwalior, MP
⁴Department of Botany, Government P.G. College Ariyalur, Tamilnadu, India
dixitshivom@gmail.com

ABSTRACT
The natural products are important source of biologically active compounds having potential for developing a novel malaria drug. Malaria is one of the most important infectious vector born parasitic disease caused by Coccidian protozoan parasite of genus Plasmodium carried out by mosquito, invade red blood cells. Malaria is thousand times more complex than any disease. In the current study, a natural ingredient of herb; Dhatura Inoxia is analyzed, for its anti-malarial activity by preparing crude extract of water and ethanol, analyzed on schizont stage of plasmodial life cycle against two Chloroquine strains: sensitive and resistant of Plasmodium falciparum isolates. The results revealed that IC₅₀ values of crude water extract was recorded as; 71± 1.41µg/ml and 105±7.07 while as the ethanol crude extract produced IC₅₀ concentrates: 52±3.53 µg/ml and 59.5± 70 µg/ml against sensitive and resistant P. f. isolates, respectively. The results showed that this herb plant possess significant antiplasmodial activity in terms of IC₅₀ as recorded in this study.