Tamil Nadu

About Authors:
SHAMBHAWI*, M SHIVASHANKAR
School of Advanced Sciences, Pharmaceutical chemistry division,
VIT University, VELLORE
India

ABSTRACT:
Chitosan has been the subject of interest for its use as a polymeric drug carrier material in dosage form design due to its appealing properties such as biocompatibility, biodegradability, low toxicity and relatively low production cost from abundant natural sources. Hydrogels are a unique class of macromolecular networks that can hold a large fraction of an aqueous solvent within their structure. The objective of this paper is to give a brief review on the fundamentals and recent advances in chitosan based hydrogel for e.g., thermosensitive hydrogel variants which precludes the need of surgical implantation as well as the description of the release mechanism of bioactive molecules from these hydrogels which traps a drug and then releases the active compound by "Swelling" or expanding inside of specific tissues, thus allowing a higher concentration of the drug in a biodegradable format. This article presents an overview of the newest developments and applications of Chitosan based hydrogel for controlled drug delivery system.

About Authors:
ANUJ SINGH
VINAYAKA MISSION’S UNIVERSITY
Salem – 636308, Tamil Nadu
anuj.dra@gmail.com

ABSTRACT:-
Healthcare Regulatory Affair Professional with their experience and strong motivation to excel in the Regulatory field has an ability to motivate & give support and strengthen to teams members, involved in process of product registration. Professional has taught a self-starter with the proven ability to prioritize and manage projects in a busy, fast-paced, multitasking environment, along with their experience in establishing relationship with the decision makers & coordinator. The Pharmaceutical industries are among the most highly regulated industries in the country. As India is growing very rapidly in pharmaceutical sector, there is a need of regulatory affairs professionals to cater the current needs of industries for the global competition. Regulatory affairs professionals are the link between pharmaceutical industries and worldwide regulatory agencies. They are required to be well versed in the laws, regulations, guidelines and guidance of the regulatory agencies. There is a growing need to incorporate the current requirements of pharmaceutical industries in the standard curriculum of pharmacy colleges to prepare the students with the latest developments to serve the industries. The present article discusses the regulatory education and its need, learning resources, courses available, syllabus contents and job opportunities in regulatory affairs.

About Authors:
S. H. Seyed Mohamed Buhary*, Kamarapu Nagaraju, A. Thanga Thirupathi.
Department of Pharmaceutics, Sankaralingam Bhuvaneswari College of Pharmacy,
Sivakasi, Tamil Nadu, India.
* nagarajukamarapu8@gmail.com

ABSTRACT:
The main goal of this study was to develop a stable formulation of antibiotic drug clarithromycin as an immediate-release tablet. The task of developing immediate release tablet is accomplished by using a suitable diluents and super-disintegrants. Faster disintegration of the tablet administrated orally minimizes absorption time and improves its bioavailability in less time.   The formulation development work was initiated with wet granulation. Microcrystalline cellulose PH 102 were used as diluent. Povidone was used as the binder. Croscarmellose sodium and pre gelatinized starchwas added as a disintegrating agent. Talc and magnesium stearate was used as the lubricant. The prepared granules were compressed into a compression machine.  To evaluate the formulated tablets as per requirements of standards. The tablets thus formulated showed  a satisfactory physical parameters, and it was found to be stable.Evalution Parameters Like weight variation, hardness of the tablet, friability, thickness, disintegration test, drug content uniformity and in vitro release studies were performed.To optimize the trial batch by    3² full factorial design study and determined  the best batch by in vitro release studies are showed that  optimization formulation (OF7) was 101.62% respectively. The  optimized formulation is further selected and compared with the release profile of the innovator product. The results suggest the feasibility of developing immediate  tablets consisting of clarithromycin for the convenience of patients with respiratory infections, gonorrhea, community-acquired pneumonia, pelvic inflammatory disease, pediatric otitis media and pharyngitis and Mycobacterium avium complex (MAC) in patients with advanced HIV disease.

About Authors:
Jeevan Sharma¹*, Davidson Rajesh^2
1B.Pharmacy, JSS college of pharmacy Ooty
²Regional manager, Natco Pharma litmited, Chennai
*jeevan.pharma@yahoo.com

ABSTRACTS:
Attrition refers to the reduction in staff and employees in a company through normal means, such as retirement and resignation. The primary focus of this  article is to present the high rate of attrition seen in the pharmaceutical marketing  industry , its causes and controlling strategy for  retentions of pharma sales representatives. Though  attrition is a natural phenomena in all industries  , Indian Pharma marketing industries is worst plagued by It. After IT and BPO , pharma  marketing industries experience  the greatest rate of employee leaving the company for various reasons. While   global pharma  marketing attrition rate  is  10-12%  per annum, the rate of employees who leave  the organization in India is 25 -30 %.  The attrition is more prevalent in the middle and junior management level.