(15th May, 2014); Researchers from Center of Advanced European Studies and the University Department of Growth and Reproduction find out large amount of endocrine-disrupting chemicals interfere with human sperm function and that may have a negative impact on fertilization. The study indicates that the chemicals might evoke changes in swimming behaviour at the wrong time and wrong place, hinder navigation of sperm towards the egg and hamper penetration into the protective egg coat.
Endocrine disruptors are available in food, textiles, drugs, household, and personal-care products such as plastic bottles, toys, and cosmetics. Proving the deleterious effects of endocrine disruptors on human beings has been difficult due to a lack of suitable experimental systems.
The work published in EMBO reports, suggests that endocrine disruptors may contribute to widespread fertility problems in the Western world in a way that hitherto has not been recognized.
Researchers developed a new bioassay through which hundreds to thousands of chemicals can be rapidly tested for their potential to interfere with human sperm. In this initial study, about one hundred chemicals were tested. Around one third, including ultraviolet (UV) filters like 4-methylbenzylidene camphor (4-MBC) used in some sunscreens, the anti-bacterial agent Triclosan used in toothpaste, and di-n-butylphthalate (DnBP), showed adverse actions.
The scientists looked at the impact of these chemicals on the CatSper ion channel, a calcium channel controlling sperm motility. They showed that endocrine disruptors – applied at concentrations measured in body fluids – directly open CatSper and, thereby, increase calcium levels in sperm, change their swimming behavior, and trigger the release of digestive enzymes that help sperm to break through the egg coat. Moreover, endocrine disruptors render sperm less sensitive for progesterone and prostaglandins – two important hormones released by cells surrounding the egg. Finally, the authors noted that in low-dose mixtures, the chemicals cooperate to elevate calcium levels in sperm.
“For the first time, we have shown a direct link between exposure to endocrine disrupting chemicals from industrial products and adverse effects on human sperm function,’’ said Niels E. Skakkebaek, professor University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.
“Our study provides scientific evidence to assist forming international rules and practices,” said the leader of the study, Timo Strünker, from the Center of Advanced European Studies and Research in Bonn, Germany.
