Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support. At Pfizer, colleagues in more than 90 countries work every day to help people stay happier and healthier longer and to reduce the human and economic burden of disease worldwide.
Post: ADME Scientist
Job ID: 939324
The qualified candidate will operate within the New Biological Entity- Pharmacokinetics, Dynamics and Metabolism (NBE-PDM) organization in the NBE-ADME Science and Technology group.
Responsible for independent initiation and execution of scientific research to evaluate biotherapeutic disposition, advance programs and biotherapeutic science, influence and inform external and internal regulator positions and support pursuit of strategic alliances and external collaborations to deliver novel science in this discipline.
The successful candidate will have experience to design, conduct and interpret lab experiments to evaluate biotherapeutic disposition in pre-clinical models, and provide leadership to advance science related to ADME properties of novel biologics.
Candidate will be responsible for establishing methodology for predictive and investigative in vivo disposition, elucidating clearance mechanisms and tissue targeting, and evaluating disposition of novel platforms and scaffolds as well as delivery technologies for biologics. Candidate will develop partnerships in a matrix environment, influence project strategies, and provide leadership in ADME technology development and implementation. Candidate will work in collaboration with biotherapeutic formulation science, global biological technologies, PDM NBE principle investigators and NBE PKPD and bioanalytical scientists to advance the knowledge and optimization of biotherapeutic biodistribution and disposition kinetics.
Mentors other ADME scientists.
Qualifications:
PhD level education with >3 years post-doctoral or industry experience in cell biology, in vivo disposition kinetics or relevant scientific field; Extensive experience in drug discovery/development of biopharmaceuticals.
Broad understanding and skill in areas of in vitro and in vivo laboratory techniques, ideally related to biotherapeutics (e.g. protein chemistry, molecular biology, cell culture, target binding, evaluation of inter-molecular interactions, use of sub cellular fraction, radiolabel studies, flow cytometry, biotherapeutic characterization technologies including chromatographic and electrophoretic, immunochemical and hybridization methods etc).
Experience in evaluating ADME of siRNA and oligonucleotide therapeutics is preferred.
Experience in evaluating alternative delivery approaches for biotherapeutics (e.g. pegylation, liposomal or polymeric, extended half-life or local retention) is preferred.
Demonstrated ability to integrate data from multiple sources into a rational understanding of distribution and clearance properties of biotherapeutics
Proven track record of influencing projects and project teams, particularly in areas of emerging science and achieving results in a matrix environment.
Proven presentation skills. Demonstrated through internal and external presentations on own work at conferences.
Proven track record in mentoring and coaching
Collaborative skills and effective partnering skills in a complex, multi-discipline organizational model.
- Level and title will be commensurate with the experience and education level of the selected candidate.
Throughout our 153 years, a legacy of caring for others has been at the heart of everything we do at Pfizer. This commitment is no less important when it comes to our employees. Pfizer wants to ensure that employees have resources to help them develop and succeed both in their careers and personal lives. One way we can achieve this is through our comprehensive benefits program, which offers employees and their eligible dependents the variety and flexibility to help address their needs at different stages in life.
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