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ABOUT AUTHORS:
*Saka, O. S; Olayode, A. A; Adelodun, S. T
Department of Anatomy and Cell Biology,
Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
olusolasaka1@gmail.com

ABSTRACT
This study was designed to evaluate the effects of garlic extracts on the morphology of myocardium of left ventricle of the heart and also determine the body weight and relative weight of the organs on high salt fed adult Wistar rats. Twenty-five healthy female Wistar rats weighing 130-180 g were randomly assigned into 5 groups of 5 rats each (Groups A, B, C, D and E). Rats in group A was fed with standard laboratory pellets, while groups B, C, D and E were fed on the high-salt diet for five weeks. Thereafter, daily administration of 50 mg kg^-1, 100 mg kg^-1 and 150 mg kg^-1 of the garlic extract were giving orally to groups C, D and E respectively for 3 weeks. The rats were sacrificed under ketamine anesthesia (5mg/kg i.m). The left ventricle of the heart was excised, processed routinely in paraffin wax and stained with routine special stained. Result showed significant decreased (p<0.05) in weight of all high salt fed groups when (F=46.90, p<0.05) compared with control. Whereas, treatment with garlic extract help in weight management in high salt fed+garlic extract treated groups and also no significant difference (p<0.05) in the relative heart weight when (F=1.773, p<0.05) compared the control with other groups. Histological results revealed morphological alterations in the left ventricle in high salt fed group. In conclusion, Garlic extract has ameliorative property at the level of 100 mg kg^-1 or 150 mg kg^-1 of the extract on high salt fed induced cardiac injury.

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