PAREXEL International is a growing, fast-paced, global Clinical Research Organization (CRO) that has helped bring to market 49 of the top 50 selling pharmaceuticals. In fact, we have worked with all 10 of the world's top 10 pharmaceutical companies.

Baba Farid University of Health Sciences was established under an Act passed by the Legislature of the State of Punjab in July, 1998.

About Author:
Hardik Patel^*, Sagar Solanki
Department of Pharmaceutical Chemistry,
K.B.Raval College of Pharmacy, Shertha,
Gandhinagar-382423, Gujarat, India.
*patel1928@yahoo.in

ABSTRACT
A new, simple, rapid, accurate, precise and sensitive method has been developed for the simultaneous estimation of Furosemide and Spironolactone in their combined tablet dosage form. The method was carried out on a Hiber C₁₈ column (250 mm×4.6mm, i.d.5 μm) with a mobile phase consisting of acetonitrile: water at a flow rate of 1 ml/min and the detection was carried out at 237 nm. The retention time of Furosemide and Spironolactone was 3.81 min and 7.28 min. respectively. Linearity for Furosemide and Spironolactone were found in the range of 2-10 μg/ml and 5-25 μg/ml respectively. The developed method was validated in terms of linearity, accuracy, and precision, limit of detection (LOD) and limit of quantification (LOQ). The proposed method can be used for estimation of both drugs in their combined dosage form.

About Authors:
1) Mr Jaesh N.Jadhav
M.Pharm,Sinhagad Institute of pharmacy,Pune.
2) Mr. J.G. Chandorkar*.
Head Analytical development laboratory,
Indofil Industries limited,Thane
*Jayant.chandorkar@rediffmail.com

Abstract
A present work describes a simple & accurate reversed phase HPLC Method for the simultaneous estimation of Ortho Chlorophenol [OCP], 2,6 – Dichlorophenol [DCP], 1-(2,6-Dichlorophenyl) indolin-2-one [VTCL], 1(2,6-Dichlorophenyl) N-Phenyl, N-Chloro Acetyl, 2,6-Dichloro Aniline [VTDL], 1(2,6-Dichlorophenyl) ether [DCPE], 1(2,6-Dichlorophenyl) amine [DCPA] in Diclofenac Sodium bulk manufacturing. This paper describes a new rapid, easy Isocratic reversed phase HPLC method for the separation and estimation of six intermediates and Diclofenac Sodium. The primary purpose of this study is to compile HPLC data on the determination of these seven products, the compilation of such HPLC data being useful as reference guide.

Hindustan Aeronautics Limited (HAL), a Navaratna Central Public Sector undertaking, is a premier Aeronautical Industry of South East Asia, with 20 Production/Overhaul/Service Divisions and 10 co-located R&D Centers spread across the Country.

It is proposed to engage full time Para Medical staff for the following posts purely on contract basis on BCT Division of Western Railway. The details of the post, place of posting, remuneration etc. and other terms and conditions stipulated are given below:-

FOR MEDICAL REPRESENTATIVE JOBS *URGENT REQUIREMENT IN ‘RANBAXY MAXXIM’ FOR ADILABAD, NARSARAOPETA, BOBBILI HQS .

Post: TERRITORY EXECUTIVE

The Department of Biotechnology, Ministry of Science & Technology (Government of India) has established the Translational Health Science and Technology Institute (THSTI), an autonomous institution, as a part of the interdisciplinary Health Biotech Science Cluster, in the National Capital Region.

National Institute of Pharmaceutical Education and Research (NIPER) is the first national level institute in pharmaceutical sciences with a proclaimed objective of becoming a centre of excellence for advanced studies and research in pharmaceutical sciences. The Government of India has declared NIPER as an ‘Institute of National Importance’.

About Authors:
Sanjay Kumar Yadav^*1, Anjana Yadav¹, Shahana Majumder^2
*1Dept of Pharmaceutical Chemistry, B.B.S. Institute of Pharmaceutical & Allied Sciences, Greater Noida, (U.P.), India
¹Dept of Biotechnology, Chhatrapati Sahu Ji Maharaj University, Kanpur, (U.P.), India
²Dept of Biotechnology, Sharda University, School of Engineering and Technology,
Greater Noida, (U.P.), India
*sanjay_yadav3333@yahoo.co.in

ABSTRACT
Viruses are pathogens with an extremely narrow host range. Their phylogenetic origin is vague, tough it has always been considered that viruses are genes that became vagrant after having excluded themselves of the host’s or a related species’ genome (Anderson et.al., 2004). Viruses are usually units consisting of nucleic acids and coat proteins called capsids. Viroids consist only of RNA, i.e. they contain no protein at all. Except for a few cases, Viruses have no energy metabolism of their own. Consequently, they cannot perform syntheses and are thus unable to replicate themselves. Depending on their host species, it is distinguished between plant viruses multiplying almost exclusively within plant cells, bacterial viruses (bacteriophages) that depend on living bacteria, and animal viruses. The genetic information of viruses is either encoded by single-stranded RNA (Most plant viruses), double-stranded RNA (Wound tumor viruses), single-stranded DNA (Gemini viruses) or double stranded DNA (Cauliflower mosaic virus). Based on the shape of the viruses particle, it is distinguished between rod shaped and icosahedral viruses with a capsid that seem almost spherical. Viruses’ cause many disease in humans of international importance for example  smallpox polio, hepatitis etc. viruses cause also many important plant disease and are responsible for huge loss in crop production and quality in all part of the world. Around 25 years ago, when genomic properties of geminiviruses were studied, many scientists regarded them as ‘friends of humans’, because of their  potential as gene transfer vectors in plant genetic engineering and non-harmful effects on host plants. But far from being friends, these viruses have now emerged as foes and are a serious threat to world agriculture now. Increase in international commodity trade, intercontinental transportation networks and a changing global climate have contribute to the spread of this virus and its whitefly vector (Moffat et.al.,1999).

About Authors:
*Thoriya J. G, Patel S. D, Tank H. M
Matushree V. B. Manvar College of Pharmacy- Dumiyani,
Rajkot
*thoriya.jignesh@gmail.com

ABSTRACT
Pioglitazone HCl is used for the management of type-2 diabetes. It is an absorption window limited drug, whose solubility decreases with increase in the pH and has a short half life of 3-7 h. Here an attempt is made to developed the floating matrix tablets, which design in way that after oral administration the GI resistant time is  prolonged and thus to give sustained action with increase in the bioavailability of the drug. Pioglitazone HCl showed maximum absorption at wavelength 269 nm in 0.1N HCl. various formulations were developed by using release rate controlling and gel forming polymers like HPMC, and Carbopol-934 in single and combinations by direct compression method with the incorporation of sodium bicarbonate as gas generating agent. The prepared tablets were characteristics by drug content, floating property, swelling and in vitro dissolution test using USP dissolution test apparatus Type – II (paddle method) in dissolution medium of 0.1 N HCl. The in vitro dissolution results of all tablets were computed by using dissolution software. The prepared tablets were found to be good hardness, diameter, weight variation, thickness, friability drug content, floating property and in vitro drug release. Drug-polymer compatibility studies by FTIR gave conformation about drug purity and showed no interaction between drug and selected polymers. All the formulations had floating lag time below 3 minutes and constantly floated on dissolution medium for more than 12 h. Swelling studies indicated significant water uptake and contributed in drug release. From among all the developed formulations, as F7 prolonged the drug release (95.45 %) for longer period of time (12 hrs.); they were selected as best formulations. The best formulations were found to be stable during stability studies for two months. Thus, selected formulations satisfied floating time, swelling index and in vitro drug release profile requirements for a floating drug delivery system.Tablets of Pioglitazone HCl prepared with HPMC K4M, HPMC K100M and Carbopol 934P were found to be acceptable floating property, water uptake and in vitro drug release.

NEXTUS SOLUTIONS is a professionally managed organization engaged in offering highly acclaimed consulting, Training and Placement.

Banaras Hindu University ranks among the first few in the country in the field of academic and research output.

About Authors:
Vedant Pandya
M.Sc. Biotechnology,
Department  Of  Biotechnology,
Shree M.N.Virani Science College, Rajkot
vedantpandya007@gmail.com

Abstract :
The potential of Cosmarium species, belonging to green Micro algae, was investigated as a viable biomaterial for biological treatment of triphenylmethane dye, Malachite Green (MG).  This can be used for the bioremediation of dye effluents. The results obtained from the batch experiments revealed the ability of algal species in removing dye.  The effects of operational parameters (temperature, pH, dye concentration and algal  concentration) on decolorization were examined.  The stability and efficiency of the algae in long-term repetitive operations were also examined. Michaelis–Menten kinetics was used to describe the apparent correlation between the decolorization rate and the dye concentration.

About Authors:
Deepak Sharma*, Arunabha Banik, S k Gupta
Department of Pharmaceutical Technology,
MIET,Meerut
*thakraan.southcarolina@gmail.com

ABSTRACT
The Microspongesdelivery system are extremely small, inert,indestructibleclusters of even tinierspherical particles of microscopic sizepatented polymeric delivery systems consisting of porous microspheres that can entrap a wide range of active ingredients such as emollients, fragrances, essential oils, sunscreens, and anti-infective, anti-fungal, and anti-inflammatory agents and are very well tolerated, and highly efficacious, novel productsthat do not pass through the skin, capable of holding four times their weight in skin secretionsand can absorb skin secretions. Like a true sponge, each microspheres consists of a myriad of interconnecting voids within a non-collapsible structure with a large porous surface. The size of the microsponges can be varied usually from 5-300µm in diameter, depending upon the degree of smoothness or after-feel required for the end formula. Although the microsponge size may vary, a typical 25µm sphere can have up to 250000 pores and an internal pore structure equivalent to 10ft in length providing a total pore volume of about 1ml/g. This results in a large reservoir within each microsponge, which can be loaded with up to its own weight in active agent. The microsponge particles themselves are too large to be absorbed into the skin and this adds a measure of safety to these microsponge materials. Another safety concern is the potential bacterial contamination of the materials entrapped in the microsponge. Because the size of the pore diameter is smaller than bacteria, ranging from 0.007 to 0.2µm, bacteria cannot penetrate into the tunnel structure of the microsponges.The microsponge system can prevent excessive accumulation of ingredients within the epidermis and the dermis. Potentially, the microsponge system can reduce significantly the irritation of effective drugs without reducing their efficacy.

The CSIR-Institute of Himalayan Bioresource Technology, Palampur is one of the National Institute under the Council of Scientific & Industrial Research which is an Autonomous Body. It is located on a 250 acres of land with the backdrop of snow-covered peaks of Dhauladhar Range in salubrious climate. The Institute is engaged in research and technology development programmes for sustainable management of bioresources of the Himalayas.

Applications are invited from suitable candidates for appointment of Sr.consultant on fixed fee per month as indicated below for a period of one year which may further be extended depending on performance in the National Medicinal Plants Board Deptt. of AYUSH, Ministry of Health and Family Welfare for implementation of the “Centrally Sponsored Scheme of National Mission on Medicinal Plants” in States/UTs.

The State of Kerala was formed on 1st November 1956 consequent on the Reorganisation of States. It comprises the former Travancore-Cochin State (except the present Kanyakumari District and Shencottah Taluk of the present Tamil Nadu) and the Malabar District and the Kasargod Taluk of South Kanara District of the then composite Madras State.

One time career opportunity for Fresher life sciences candidates: M.Sc, B.Pharm, M.Pharm. MBBS, BDS, MD, B.Tech, M.Tech, to join as Project Trainee in BioCampus, GVK Bio - 20 Vacancies