OCT 2014 ARTICLE LIST >>
PharmaTutor (October- 2014)
ISSN: 2347 - 7881
(Volume 2, Issue 10)
Received On: 07/07/2014; Accepted On: 22/07/2014; Published On: 01/10/2014
AUTHORS: Mayure Vijay Kumar*, V. Sravanthi
Maheshwara College of Pharmacy (B-Pharm Scholar)
Department of pharmacology,
Maheshwara College of Pharmacy, Chitkul (V), Isnapur “X” Road, Patancheru, Hyderabad, A.P.
mayurevijaykumar@gmail.com
ABSTRACT:
The anaesthetic agents are the drugs which causes anaesthesia-reversible loss sensation. It deals with the property of relieving the pain without eliminating sensation. These drugs are generally administered to facilitate surgery. It can be described by two main classes. General anaesthetic, which causes a reversible loss of consciousness, and local anaesthetics, which causes a reversible loss of sensation for a limited region of the body while maintaining consciousness. Here I explain about the Local anaesthetics agents that prevent transmission of nerve impulses without causing unconsciousness. They act by binding to fast sodium channels from within in an open state.
BACKGROUND: The purpose of this Review article is to summarize the Local anaesthetics agents, general mechanism, structures, therapeutic uses, adverse effects and also explains their properties.
How to cite this article: VK Mayure, V Sravanthi; Local Anaesthesia (LA): An Overview; PharmaTutor; 2014; 2(10); 68-79
[ABSTRACT WITH CITATION] [VIEW AS HTML]
REFERENCES:
1. “Lidoderm”. RxWiki.
2. Porto GG, Vasconcelos BC, Gomes AC, Albert D “Evaluation of lidocaine and mepivacaine for inferior thiard molar surgery”. Med oral Patol oral cir Bucal January 2007, 12 (1):E60-4.
3. United States Pharmacopial convention. “Revision Bulletin: Lidocaine and prilocaine Cream-Revision to Related compounds Test”. Retrieved 10th July 2009.
4. Rossi S, editor, Australian Medicines Handbook Adelaide: Australian Medicines Handbook: 2006.
5. Rossi S, editor, Australian Medicines Handbook Adelaide: Australian Medicines Handbook: 2006.
6. Duranest (RxList)
7. Rossi S, editor, Australian Medicines Handbook Adelaide: Australian Medicines Handbook: 2006.
8. Martindale, The Extra Pharmacopoeia, 30th ed, p 1006.
9. Sawaki, k; and Kawaguchim, M. “some correlations between procaine-induced convulsions and monoamides in the spinal cord of rats”. Japanese Journal of pharmacology, 1989, 51 (3), p.369-376.
10. Karen A Russo, ph.D., Scientist Expert Committee: (PA1) pharma.Analysis 1 USP28-NF23 P.1646.
11. Hughes: Anesthesia for pbstetrics, 4th ed, p75.
12. Brill, J.Am.Chem.Soc.43, 1322(1921): adams, volwiler, US1440652 (1923 to abbott); C.A.21, 2478, 1927.
13. Garner, Dwight “Endurance Condoms”. The New York Times. 15 Dec 2002.
14. Barnet G, Hawks R, Resnick R. “Cocaine Pharmacokinectics in Humans”. J Ethnopharmacol 1981, 3 (2-3): 353-66.
15. Winthrop Chemical Company, Inc US patent 1,889, 645, 1932.
16. nlm.nih.gov/medline plus/druginfo/meds/a642429.html.
17. National Centre for biotechnology information. U>S National Library of Medicine 8600 Rockville Pike, Bethesda MD 20894USA.
18. Seifter J, Glassman JM, Hudyma GM. “Oxethazine and related congeners: a series of highly potent local anaesthetica”. Proc soc Exp Biol Med 1962, 109: 664-8.
19. Sawaki, k; and Kawaguchim, M. “some correlations between procaine-induced convulsions and monoamides in the spinal cord of rats”. Japanese Journal of pharmacology, 1989, 51 (3), p.369-376
20. Hughes: Anesthesia for pbstetrics, 4th ed, p75.
21. “Lidoderm”. RxWiki.
22. United States Pharmacopeial convention. “Revesion Bulletin: Lidocaine and prilocaine Cream-Revision to Related compounds Test”. Retrieved 10th July 2009.
23. Winthrop Chemical Company, Inc U.S.patent 1,889, 645, 1932.
24. Rossi S, editor, Australian Medicines Handbook 2006. Adelaide: Australian Medicines Handbook: 2006.
25. Rossi S, editor, Australian Medicines Handbook Adelaide: Australian Medicines Handbook: 2006.
26. Martindale, the Extra Pharmacopoeia, 30th ed, p1006.
27. Barnet G, Hawks R, Resnick R. “cocaine pharmacokinectics in humans”. J Ethnopharmacol 1981, 3 (2-3): 353-66.
28. “Lidoderm”. RxWiki.
29. Winthrop Chemical Company, Inc U.S.patent 1,889. 1932, 645.
30) Garner, Dwight “Endurance Condoms”. The New York Times. 15 Dec 2002.
31. seifter J, Glassman JM, Hudyma GM,. “Oxethazine and related congeners: a series of highly potent local anaesthetica”. Proc soc Exp Biol Med 1962, 109: 664-8.
32. Brill, J.Am.Chem.Soc.43, 1322, 1921: adams, volwiler, US1440652 (1923 to abbott); C.A.21, 2478, 1927.