OCT 2014 ARTICLE LIST >>
PharmaTutor (October- 2014)
ISSN: 2347 - 7881
(Volume 2, Issue 10)
Received On: 13/07/2014; Accepted On: 21/07/2014; Published On: 01/10/2014
AUTHORS: Umatiya Imran*, Chintan Aundhia, A.K.Seth, Sachin Chauhan, Nirmal Shah
Department of pharmacy, Sumandeep Vidhyapeeth University,
Piparia, Waghodia, Vadodara, Gujarat, India
imran_umatiya@yahoo.com
ABSTRACT:
Tuberculosis is an infectious disease caused by Mycobacterium Tuberculosis which attacks lungs and other parts of the body. Isoniazid is a hydrophilic drug that is having a first line antituberculosis drug. Entrapment Efficiency has been improved by preparing Solid Lipid Nanoparticles (SLNs). Two different variable Stearic acid and Tween 80 were used by using w/o/w double emulsion-solvent evaporation method by using 32 factorial designs. Particle size, Surface Morphology, Entrapment efficiency and In-vitro diffusion studies were evaluated for prepared SLNs. Different combination of Surfactant and Lipid were found to have significant effect on entrapment efficiency but not on drug release. The prepared SLNs were found in spherical shape and 678 nm particle size was found. % Entrapment efficiency were found from 31.90±0.41 to 74.89±0.67. Present Work is focused on increase incorporation of drug into SLN. Work indicates that formulation of SLNs loaded INH can give reliable therapeutic effect for the treatment of tuberculosis by prolonged action.
How to cite this article: I Umatiya, C Aundhia, AK Seth, S Chauhan, N Shah; Formulation and Evaluation of Solid lipid nanoparticles: Isoniazid; PharmaTutor; 2014; 2(10); 129-135
[ABSTRACT WITH CITATION] [VIEW AS HTML]
REFERENCES:
1.Sarathchandiran I, “A Review on nanotechnology in solid lipid nanoparticles”, IJPDT,2012,2(1):45-61
2.Ekambaram P, “Solid lipid nanoparticles: A Review”, Sci.Revs.Chem.Commun.2010, 2(1):80-102
3.Nair R, “Formulation and Evaluation of Solid Lipid Nanoparticles of Water Soluble Drug: Isoniazid”, J. Pharm. Sci. & Res,2011,3(5):1256-1264
4.Gulbake A, “Solid lipid nanoparticles bearing oxybenzone:In-vitro and In-vivo Evaluation” Journal of microencapsulation,2010, 2(3): 223-226
5.Sanjay S, “Formulation and Evaluation of Solid Lipid Nanoparticles of Water Soluble Drug: Zidovudine”. Chem. Pharm. Bull 2010; 58(5):650-655
6.Kausik M, “Formulation development and evaluation of solid lipid nanoparticles of aceclofenac using solvent injection method, Journal of Drug Delivery & Therapeutics 2012,2(4):97-100
7.Kheradmandnia S, “Preparation and characterization of ketoprofen-loaded solid lipid nanoparticles made from beeswax and carnauba wax. ”, NBM, 2010,6:753-759
8.Zhiwen Z, “Solid lipid nanoparticles loading candesartan cilexetil enhance oral bioavailability: in vitro characteristics and absorption mechanism in rats” Nanomedicine,2012,8:740-747
9.Vishvajit A. “Solid lipid nanoparticles as drug delivery system”, Int. J. Pharm,2010;1(3):1-9
10.Umaretiya G, “Formulation and characterization of solid lipid nanoparticles dry powder inhaler containing Triamcinolone acetonide”, IJRPC ,2011;1(3):662-673
11. Schwarz C, “Freeze-drying of drug-free and drug-loaded solid lipid nanoparticles (SLN)”, Int.J. Pharma,1997,157: 171–179
12.Chakrapani M, Rahul N, “Formulation and Evaluation of Solid Lipid Nanoparticles using Lipids of Natural Origin”, JITPS 2012,.3(3):80-87
13.Soo-Jeong L, “Formulation parameters determining the physicochemical characteristics of solid lipid nanoparticles loaded with all-trans retinoic acid”, Int.J.Pharm2002,243(67): 135–146
14. Jameel AM, “Formulation, Characterization, and in vitro Evaluation of Methotrexate Solid Lipid Nanoparticles”, Research J. Pharm. and Tech, 2009, 2(4): 611-16.
.png)
