NOVEMBER 2015 ARTICLE LIST >>
PharmaTutor (November- 2015)
Print-ISSN: 2394 - 6679
e-ISSN: 2347 - 7881
(Volume 3, Issue 11)
Received On: 20/07/2015; Accepted On: 29/07/2015; Published On: 01/11/2015
AUTHORS:
B. Venkateswara Reddy
Department of Pharmaceutics,
St. Pauls College of Pharmacy, Hayathnagar, R.R.Dist, India.
basu.pharmacist@gmail.com
ABSTRACT: Objective: Cefixime is a third generation cephalosporin antibiotic having bactericidal activity by inhibition of cell wall synthesis and is used in the treatment of uncomplicated UTI, pharyngitis and tonsillitis, acute bronchitis and acute exacerbation of chronic bronchitis, uncomplicated gonorrhoea etc. The concept of formulating floating tablets containing Cefixime offers a suitable and practical approach in serving desired objective of retaining the drug in the stomach to increase the its bioavailability.
Methods: The tablets were prepared by direct compression methodand total of 12 formulations are developedemploying HPMC K100M and HPMC K15M as polymers for sustaining the drug release and sodium bicarbonate as the gas generating agent.
Results: Various polymers have been selected and subjected to IR-spectroscopic studies and found that there were no drug–excipient interactions. The powder blends of all the formulations have shown good flow properties. Other parameters such as hardness, friability, drug content uniformity, Floating lag time and in-vitro dissolution studies were performed and the results were satisfactory.
Conclusion: Formulation F 12 was found to be best in all aspects and was considered as optimized formulation, it has a low floating lag time of 2mins and has shown a maximum drug release of 99% at the end of 24 hours and drug release was by diffusion through the polymer matrix.
How to cite this article: BV Reddy; Formulation development and In-Vitro evaluation of floating tablets of Cefixime; PharmaTutor; 2015; 3(11); 48-57
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