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PharmaTutor (May- 2014)
ISSN: 2347 - 7881
Received On: 28/03/2014; Accepted On: 04/03/2014; Published On: 01/05/2014
Author: Nandu Kayande1*, Pankaj Kushwah2
1Department of Pharmacology
2Department of Pharmacognosy
Nimar Institute of Pharmacy, Dhamnod,
Dhar, Madhya Pradesh, India
nandu_kayande@rediffmail.com
ABSTRACT:
The aim of presents study is to evaluate antidiabetic (Hypoglycemic) effect of Gymnema Sylvestre extract in alloxan induced diabetic Swiss albino mice. These aqueous extract were used for the study. The Swiss albino mice weighing 25 to 30 gm were used for the study. Mice were administered orally with the aqueous extracts of Gymnema Sylvestrewith dose of 200 mg/kg, 400 mg/kg and 500 mg/kg. body weight from period of day 1 to 28 days. The study reveals that the all the three doses shows the significant decrease in blood glucose level. This study shows the significant activity of gymnema sylvestre extracts against alloxan induced diabetes. These prove the guava fruit is pancreatic protective and hypoglycemic in nature.
How to cite this article: N Kayande, P Kushwah; Antidibetic Evaluation of Gymnema Sylvestre Extracts in Experimental Animals; PharmaTutor; 2014; 2(5); 120-123
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REFERENCES:
1.Dinesh Kumar Sekar, Gaurav Kumar, L. Karthik and K. V. Bhaskara Rao, A review on pharmacological and phytochemical properties of Aegle marmelos (L.) Corr. Serr. (Rutaceae), Asian Journal of Plant Science and Research, 2011, 1 (2): 8-17.
2.Anthony C. Dweck FLS FRSC FRSH Dweck Data, A review of Guava (Psidium guajava).
3.Baby Joseph, D Jini, Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency, Asian Pacific Journal of Tropical Disease, 2013; 3(2): 93-102.
4.Takashi Akiyoshi, Kiyohisa Uchida, Haruto Takase, Yasuharu Nomura, and Nozomu Takeuchi, Cholesterol gallstones in alloxan-diabetic mice, Journal of Lipid Research Volume 27, 1986.
5.National tropical botanical garden, ntbg.org/plants/plant_details.php?plantid=9567.
6.Gonçalves FA, Andrade Neto M, Bezerra JN, Macrae A, Sousa OV, Fonteles-Filho AA, Vieira RH.,Antibacterial activity of GUAVA, Psidium guajava Linnaeus, leaf extracts on diarrhea-causing enteric bacteria isolated from Seabob shrimp, Xiphopenaeus kroyeri (Heller). Pubmed, 2008 Jan-Feb;50(1):11-5.
7.Mohamed Ismail1, Minhas PS, Fathima Khanum, Sahana VM and Sowmya C2, Antibacterial Activity of Leaves Extract of Guava (Psidium Guajava), International Journal of Research in Pharmaceutical and Biomedical Sciences, Vol. 3 (1) Jan – Mar 2012
8. S. Buvaneswari, C.K.Raadha, N.Krishnaveni, S.Jayashree, In-vitro Antimicrobial activity of Psidium guajava against clinically important strains, E-Journal of Life Sciences, EJLS 2011, 1(1),14-22.
9.Ankur Rohilla and Shahjad Ali, Alloxan Induced Diabetes: Mechanisms and Effects, International Journal of Research in Pharmaceutical and Biomedical Sciences, Vol. 3 (2) Apr – Jun2012.
10.Mohamed Bnouham*, Abderrahim Ziyyat, Hassane Mekhfi, Abdelhafid Tahri, Abdelkhaleq Legssyer, Medicinal plants with potential antidiabetic activity - A review of ten years of herbal medicine research (1990-2000), Int J Diabetes & Metabolism (2006) 14: 1-25 .
11.Manisha Yadav , Khalid Kafeel Khan And M.Z.Beg, Medicinal Plants Used For The Treatment Of Diabetes By The Baiga Tribe Living In Rewa District M.P., Indian J.L.Sci.2(1) : 99-102, 2012.
12.Nagaraja PURANIK, Kararashah Fakruddin KAMMAR, Sheela DEVI, Anti-diabetic activity of Tinospora cordifolia (Willd.) in streptozotocin diabetic rats; does it act like sulfonylureas?, Turk J Med Sci 2010; 40 (2): 265-270.
13.M. Ayyanar, K. Sankarasivaraman and S. Ignacimuthu, Traditional Herbal Medicines Used for the Treatment of Diabetes among Two Major Tribal Groups in South Tamil Nadu, India, Ethnobotanical Leaflets 12: 276-280. 2008.
14.Sanjeev Heroor, Arunkumar, Synergistic activity of bark extracts of pongamia, World Journal of Pharmacy and Pharmaceutical Sciences, Volume 2 issue-6, 6640-52.
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