June 2018 ARTICLE LIST >>
PharmaTutor (June - 2018)
ISSN: 2347 - 7881
(Volume 6, Issue 6)
Received On: 10/03/2018; Accepted On: 24/04/2018; Published On: 01/06/2018
AUTHORS:
Poonam R. Ithape*, Priyanka D. Ghadage, Jayant K.Gadhve, Akash S.Mali
Department of Pharmacy,
Gourishankar Institute of Pharmaceutical Education and Research,
Limb, Satara, Maharashtra, India
poonamithape6996@gmail.com
ABSTRACT
The focus of present study is to exhibit novel methods for pediatric oral drug delivery. To overcome the problems associated with drug administration, toxicity and taste preference the drug designed in such way that it best suits to child age, required treatment, size and physiological condition. Pediatrics differs from adult in many aspects of pharmacotherapy. Palatability is the biggest challenge while designing the pediatric formulation. As the vast no of limitation present in solid formulation there is wide scope in novel research in designing the pediatrics drug delivery system. Novel approaches in oral drug delivery system is somewhat satisfy the challenges but not the give proper solution. To overcome these problems the novel innovative researches is going on. The formulation should be designed in such a way that is easy to administer for pediatrics, having dose flexibility and better palatability of drug formulation.
How to cite this article: Ithape P, Ghadage P, Gadhve J, Mali A; Oral Drug Delivery System Challenges to Pediatrics and Current Approaches; PharmaTutor; 2018; 6(6); 9-13; http://dx.doi.org/10.29161/PT.v6.i6.2018.9
[ABSTRACT WITH CITATION] [VIEW AS HTML]
REFERENCES:
1. Anne cram, Breitkreutz J, Desset-Brèthes S, Nunn T, Tuleu C (2009); “Challenges of developing palatable oral paediatric formulation”; International journal of Pharmaceutics; 365(1-2); 1-3
2. Batchelor HK, Fotaki N, Klein S (2014); “Pediatric oral Biopharmaceutics: key considerations and current challenges”; Adv Drug Delivery Rev; 73; 102-126
3. Cuna M, Villa Jaltojs and Torres D (2000); “Control release liquid suspension based on ion exchange particle entrapped within acrylic microcapsule”; International journal of Pharmaceutics; 199(2); 151-158.
4. Ivanovska V, Carin M.A. Rademaker, Liset van Dijk, Aukje K. Mantel-Teeuwisse (2014); “Pediatric drug formulation: a review of challenges and progress”; Pediatrics; 134(2); 361-372
5. Felipe L Lopez, Ernest TB, Tuleu C, Gul MO (2015); “Formulation approaches to paediatric oral drug delivery: benefit and limitation of current platform”; Expert opinion drug delivery; 12(11); 1727-1740
6. Kraus DM, Stohlmeyer LA, Hannon PR, Freels SA. (2001); “Effectiveness and infant acceptance of the Rx medibottel versus the oral syringe”; Pharmacotherapy; 21(4); 416-423
7. Marcia L.Buck (2013); “Alternative forms of oral drug delivery for pediatric patient”; Pediatric Pharmacotherapy - University of Virginia School of Medicine.
8. Matsui D (2007); “Current issues in pediatric medication adherence”; Paediatric Drugs; 9(5); 283-288
9. Meltzer EO, Welch MJ, Ostrom NK (2016); “Pill swallowing ability and training in children 6 to 11 year old age”; Clinical Pediatrics; 45(8); 725-733.
10. Mishra B, Sahoo BL, Mishra M, Shukla D, Kumar V (2011); “Design of control release liquid formulation of lomotrigim”; Daru- Journal of Faculty of Pharmacy, Tehran University of Medical Science; 19(2); 126-137
11. Van Riet-Nales DA, Schobben AF, Egberts TC, Rademaker CM (2010); “Effects of the pharmaceutical technological aspects of oral pediatric drugs on patient-related outcomes :a systemic literature review”; Clinical Therapeutics; 32(5); 924-938
.png)
