JUN 2014 ARTICLE LIST >>
PharmaTutor (June- 2014)
ISSN: 2347 - 7881
Received On: 04/04/2014; Accepted On: 10/04/2014; Published On: 01/06/2014
AUTHORS: Vishal Soni*, Amruta Anjikar
CSIR-National Environmental Engineering Research Institute (NEERI),
Nagpur, Maharashtra
*vishalsoni8912@yahoo.com
ABSTRACT:
Pyrethrins and pyrethrum are the most frequently used home and garden insecticides in the India. They are often used in indoor sprays, pet shampoos, and aerosol bombs to kill flying and jumping insects. Pyrethrins are a common cause of insecticide poisonings. According to Ministry of Environment and Forest survey of poison control centers, they cause more insecticide poisoning incidents than any other class of insecticides except the organophosphates. Symptoms include headaches, dizziness, and difficulty breathing. Pyrethrins can trigger life-threatening allergic responses including heart failure and severe asthma. In laboratory animals exposed through eating, by injection, or through breathing, pyrethrins have caused anemia. Experiments with dairy cows suggest that nursing mothers exposed to pyrethrins can pass them on to their children. Pyrethrins disrupt the normal functioning of sex hormones. They inhibit binding of sex hormones to human genital skin and proteins in human blood. Pyrethrins are classified as “likely to be human carcinogens” by Environmental Protection Agency (EPA) because they cause thyroid tumors in laboratory tests. Farmers who use pyrethrins have an increased risk of developing leukemia. Pyrethrins are extremely toxic to bees, fish, and other aquatic animals. Following indoor treatments, pyrethrins have persisted up to 2 1/2 months in carpet dust.
How to cite this article: V Soni, A Anjikar; Use of Pyrethrin/ Pyrethrum and its Effect on Environment and Human: A Review; PharmaTutor; 2014; 2(6); 52-60
[ABSTRACT WITH CITATION] [VIEW AS HTML]
REFERENCES:
[1]Toxicological profile for pyrethrins and pyrethroids. Draft. P.147-150. Dept. of Health and Human Services.
[2]McCord, C.P., C.H. Kilker, and D.K. Minster. Pyrethrum dermatitis. 1921. JAMA 77(6): 448-449.
[3]Whitmore, R.W., J.E. Kelly, and P.L. Reading. National home and garden pesticide use survey. Final report, vol. 1: Executive summary, results, and recommendations. Research Triangle Park NC: Research Triangle Institute. 1992.
[4]Casida, J.F. and G.B. Quistad. Metabolism and synergism of pyrethrins. In Pyrethrum flowers: production, chemistry, toxicology, and uses, ed. J.E. Casida and G.B. Quistad. New York NY: Oxford University Press. 1995. Pp. 259-276.
[5]Ware, G.W. The pesticide book. Fresno CA: Thomson Publications. 2000. Pp. 65-66.
[6]Crosby, D.G. Environmental fate of pyrethrins. In Pyrethrum flowers: production, chemistry, toxicology, and uses, ed. J.E. Casida and G.B. Quistad. New York NY: Oxford University Press. 1995. Pp. 194-213.
[7]Calif. Environmental Protection Agency. Dept. of Pesticide Regulation. Summary of pesticide use report data: 2000, indexed by chemical. 2001. Pp. 341-343.
[8]Ray, D.E. and P.J. Forshaw. Pyrethroid insecticides: Poisoning syndromes, synergies, and therapies. Clin. Toxicol. 2000. 38:95-101.
[9]Federal Insecticide, Fungicide, and Rodenticide Act Sec. 2.
[10]40 Code of Federal Regulations 158.340.
[11]J. Blondell, Health Effects Div. U.S. EPA. Office of Pesticides and Toxic Substances. Undated memo. Human insecticide exposures reported to poison control centers in 1991.
[12]Shafey, O., L. Mehler, and L. Baum. Illnesses associated with use of automatic insecticide dispenser units—selected states and United States, 1986–1999. 2000. MMWR 49(22): 492-495.
[13]Ramadan, A.A. et al. Action of pyrethroids on K+-stimulated calcium uptake by, and [3H] nimodipine binding to, rat brain synaptosomes. Pest. Biochem. Physiol. 1988. 32:114-122.
[14]Prasada Rao, K.S., C.S. Chetty, and D. Desaiah. 1984. In vitro effects of pyrethroids on rat brain and liver ATPase activities. J. Toxicol. Environ. Health 14: 257-265.
[15]Kakko, I., T. Toimela, and H. Tähti. Piperonylbutoxide potentiates the synaptosome ATPase inhibiting effect of pyrethrin. Chemosphere 2000. 40: 301-305.
[16]Yamano, T. and S. Morita. Effects of pesticides on isolated rat hepatocytes, mitochondria, and microsomes. Arch. Environ. Contam. Toxicol. 1993. 25: 271-278.
[17]Adams, R.M. Occupational skin disease. New York: Grune& Stratton. 1983. p. 362.
[18]Wax, P.M. and R.S. Hoffman. Fatality associated with inhalation of a pyrethrin shampoo. Clin. Toxicol. 1994. 32: 457-460.
[19]Wagner, S.L. Fatal asthma in a child after use of an animal shampoo containing pyrethrin. West J. Med. 2000. 173:86-87.
[20]Zucker, A. Investigation of purified pyrethrum extracts. Ann. Aller. 1965. 23: 335-339.
[21]Karel, A.K. and S.C. Saxena. Investigation on the acute toxic effect of pyrethrum on the blood glucose and of glucose administration on the acute pyrethrum toxicity in MerioneshurrianaeJerdon (Rodentia). Arch. Intern.Physiol.Biochim. 1975. 83:1925.
[22]Saxena, S.C. and A.K. Karel. A note on the effect of pyrethrum on haemoglobin concentration of Indian desert gerbils, Merioneshurrianae. Pyreth. 1974. 12:161-162.
[23]Karel, A.K. and S.C. Saxena. Investigations on the acute toxic effect of pyrethrum on various haemotological aspects of Merioneshurrianae Jerdon, the Indian desert gerbil. Pyreth. 1975. 13: 61-67.
[24]World Health Organization and Food and Agricultural Organization. 2000. Pesticide residues in food—1999. [Part II] Toxicological evaluations. Geneva, Switzerland: World Health Organization. Pp. 277-278.
[25]Schoenig, G.P. Mammalian toxicology of pyrethrum extract. In Pyrethrum flowers: production, chemistry, toxicology, and uses, ed. J.E. Casida and G.B. Quistad. New York NY: Oxford University Press. 1995. Pp. 249-257.
[26]Memo from L.J. Hansen to L. DeLuise. U.S. EPA. Office of Pesticides and Toxic Substances. Pyrethrum extract (technical). Evaluation of a two-generation rat reproduction study to support reregistration of pyrethrum extract. 1991.
[27]World Health Organization and Food and Agriculture Organization of the United Nations. 2000. Pesticide residues in food—2000. FAO Plant Production and Protection Paper 163. p. 114.
[28]National Research Council. Commission on Life Sciences. Board on Environmental Studies and Toxicology. 1999. Hormonally active agents in the environment. Washington, D.C.: National Academy Press, p. 10.
[29]Eubanks, M.W. Hormones and health. Environ. Health Persp. 1997. 105: 482-487.
[30]Eil, C. and B.C. Nisula, The binding properties of pyrethroids to human skin fibroblast androgen receptors and to sex hormone binding globulin. J. Steroid Biochem. 1990. 35: 409-414.
[31]Ramadan, A.A. et al. Actions of pyrethroids on the peripheral benzodiazepine receptor. Pest. Biochem. Physiol. 1988. 32: 106-113.
[32]Brown, L.M. et al. Pesticide exposures and other agricultural risk factors for leukemia among men in Iowa and Minnesota. Cancer Res. 1990. 50: 6585-6591.
[33]U.S. EPA. Office of Pesticide Programs. Health Effects Division. Cancer Assessment Review Committee. Cancer Assessment Document: Evaluation of the carcinogenic potential of pyrethrins. Executive summary. Washington, D.C. 1999.
[34]Hurley, P.M., R.N. Hill, and R.J. Whiting. Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents. Environ. Health Persp. 1998. 106: 437-445.
[35]Extension Toxicology Network... Pesticide information profile: Pyrethrins. http://pmep.cce.cornell.edu/profiles/extoxnet/pyrethrins- ziram/pyrethrins-ext.html. 2001
[36]Campbell, A. and M. Chapman. Handbook of poisoning in dogs and cats. Malden MA: Blackwell Science. 2000. p. 43.
[37]Beasley, V.R. and H.L. Trammel. Incidence of poisonings in small animals. Curr. Vet. Ther. 1989. 10: 97-113.
[38]Hudson, R. H., R.K. Tucker, and M.A. Haegele. Handbook of toxicity of pesticides to wildlife. Second edition. Washington, D.C.: U.S. Dept. of the Interior. Fish and Wildlife Service. 1984. p. 68.
[39]Saxena, S.C. and P.P. Bakre. Toxicity of pyrethrum to Blue Rock pigeon. Pyreth. 1978. 14: 47-48.
[40]Saxena, P. and Saxena, S.C. Effect of pyrethrum on body and organ weights, food consumption and faeces production of the house sparrow, Passer domesticus. Pyreth. 1973. Post 12: 76.
[41]Johnson, W.W. and M.T. FInley. Handbook of acute toxicity of chemicals to fish and aquatic invertebrates. Washington, D.C.: U.S. Dept. of the Interior. Fish and Wildlife Service. 1980. p. 70.
[42]Burridge, L.E and K. Haya. Lethality of pyrethrins to larvae and postlarvae of the American lobster (Homarusamericanus). Ecotoxicol. Environ. 1997. Safety 38: 150-154.
[43]Sanders, H.O. Toxicity of pesticides to the crustacean Gammaruslacustris. Technical Paper No. 25. Washington, D.C.: U.S. Dept. of the Interior. Fish and Wildlife Service. Bureau of Sport Fisheries and Wildlife. 1969.
[44]Gabriel, K.L. and R. Mark. Environmental toxicology of pyrethrum extract. In Pyrethrum flowers: production, chemistry, toxicology, and uses, ed. J.E. Casida and G.B. Quistad. New York NY: Oxford University Press. 1995. Pp. 277-283.
[45]Appel, A. G., Knockdown efficiency and materials’ compatibility of wasp and hornet spray formulations to honey bees (Hymenoptera: Apidae). J. Econ. Entomol. 1990, 83: 1925-1931.
[46]Ministry of Environment and Forest ‘A Survey of Poison Control Centers in 2001’.
[47]Berger-Preib, E.K. Levssen, and A. Preib. Analysis of individual natural pyrethrins in indoor matrices by HRD/ECD. J. High Resol. Chromatography. 20:284-289.