JUN 2014 ARTICLE LIST >>
PharmaTutor (June- 2014)
ISSN: 2347 - 7881
Received On: 21/03/2014; Accepted On: 03/04/2014; Published On: 01/06/2014
AUTHORS: Mehul Kakdiya*1, Anup Patel2, Darshan Madiya1, Shital Faldu1
1Department of Quality Assurance, Smt. R. D. Gardi B. Pharmacy College, Rajkot, Gujarat, India
2B.M. Shah College of pharmaceutical Education and Research, Modasa, Gujarat, India
*kakdiyamehul@gmail.com
ABSTRACT:
UV Spectrophotometric method has been developed for simultaneous estimation of Paracetamol (PCM) and Propyphenazone (PP) in their combined pharmaceutical dosage form. This method utilizes methanol as a solvent and λmax of Paracetamol and Propyphenazone selected for analysis was found to be 249 nm and 274 nm respectively. Linearity was observed in the concentration range of 1-12 μg/ml for Paracetamol (r2=0.995) and 5-24 μg/ml for Propyphenazone (r2=0.997).The method was validated statistically and by recovery studies. The mean % recovery was 98.26-99.93% and 98.36-100.24% for Paracetamol and Propyphenazone respectively. Developed method was applied to pharmaceutical dosage form. The results were found to be within acceptance criteria according to ICH guideline. This method was simple, rapid, accurate and sensitive.
How to cite this article: M Kakdiya, A Patel, D Madiya, S Faldu; Analytical Method Development and Validation for Simultaneous Estimation of Paracetamol and Propyphenazone in their Combined Pharmaceutical Dosage Form by simultaneous Equation Method; PharmaTutor; 2014; 2(6); 154-159
[ABSTRACT WITH CITATION] [VIEW AS HTML]
REFERENCES:
1. Sweet man SC., The Martindale: The Complete Drug Reference; 36th Edn; Pharmaceutical Press, London, UK, 2009, pp 978.
2. Rang HP, Dale MM, Ritter JM and Moore PK, Pharmacology, 5th Edn; Elsevier, New Delhi 2006, pp 251,442.
3. Acess as “Mechanism of paracetamol & propyphenazone.PPT” by saline parvez and waqur ali (access on 20th march,2014)
4. Indian Pharmacopoeia, Volume 3, Ghaziabad: Govt. of Indian Ministry of Health and Family Welfare, the Controller of Publication, 2007, The Indian Pharmacopoeial Commission, pp 900-03.
5. British Pharmacopoeia, Volume I-II, London: The Department of Health,: HMSO Publication; 2009, pp 2789
6. The United States Pharmacopoeia-27, NF-22, Asian edition, Rockville, MD: The US Pharmacopoeial Convention, Inc., 2004, pp 1397-98.
7. Vichare V, Mujgond P, Tambe V and Dhole SN. Simultaneous Spectrophotometric determination of Paracetamol and Caffeine in Tablet formulation. International Journal of PharmTech Research, 2010, 2(4), 2512-2516.
8. Pawar PY, Joshi RS, Jangale KN and Wagh SK. Development and Validation of a Reversed Phase HPLC Method for Simultaneous Estimation of Enalapril maleate, Hydrochlorothiazide and Paracetamol in Pure and its Pharmaceutical Dosage Form. Pelagia Research Library, 2011, 2(5), 121-127.
9. Vyas AJ, Patel JK, Bhandari A, Chavda JR and Sheth NR. SimultaneousEstimation of Lornoxicam and Paracetmaol by Vierodt’s Method in APIand in Synthetic mixture. International Journal of ChemTech Research,2011, 3(3), 1269-1273.
10. ICH guideline Q2 (R1). Validation of analytical procedures: text and methodology. Geneva: 1996.
11. Beckett AH. And Stenlake JB. Practical Pharmaceutical Chemistry, part-II; 4th Edn; CBS Publisher and Distributors, New Delhi, 2007, pp 275-336
.png)
