JUL 2014 ARTICLE LIST >>
PharmaTutor (July- 2014)
ISSN: 2347 - 7881
Received On: 18/05/2014; Accepted On: 23/05/2014; Published On: 01/07/2014
AUTHORS: B.Venkateswara Reddy*, K.Navaneetha
Department of Pharmaceutics, St. Pauls College of Pharmacy,
Turkayamjal, Hayathnagar, R.R. Dist., Andhra Pradesh, India.
*basu.pharmacist@gmail.com
ABSTRACT:
Objective: Sustained release tablets of ramipril were prepared in order to increase the half life (3 hours) of the drug and to reduce the adverse events associated with ramipril, a drug used in treatment of hypertension.
Methods: The tablets were prepared by direct compression method and evaluated for various parameters. HPMC K15, HPMC E15 and HPMC K4 were used as sustain release polymers.
Results: IR spectroscopic studies indicating that the drug is compatible with all the excipients and there was no drug-polymer interaction. The results of preformulation studies indicate that the powder blend has good flow properties. Tablets prepared by direct compression method are evaluated for thickness, hardness test, friability test, uniformity of weight, drug content estimation. All the formulation were found to be good appearance without showing any chipping, capping and sticking defects and all parameters were also passed the test.
Conclusion: When comparing all formulation, F1containing HPMC K15 showed a sustained release of 98.7% at end of 16th hour. Percentage drug release obtained from sustained release tablets of ramipril were subjected for kinetic treatment for kinetic treatment to know the release order and was found that F1 formulation follow zero order release and follow the mechanism of both diffusion and erosion.
How to cite this article: BV Reddy, K.Navaneetha; Formulation and Evaluation of Sustain Release Tablets of Ramipril; PharmaTutor; 2014; 2(7); 110-119
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