February 2017 ARTICLE LIST >>
PharmaTutor (February - 2017)
ISSN: 2347 - 7881
(Volume 5, Issue 2)
Received On: 04/10/2016; Accepted On: 26/10/2016; Published On: 01/02/2017
AUTHORS:
Deepak Chowrasia1*, Nisha Sharma1, Mohammad Arshad2
1University Institute of Pharmacy, CSJM University, Kanpur, U.P.-208024, India
2Molecular Endocrinology Lab, Department of Zoology, Lucknow University, Lucknow, U.P.-226007, India
* chowrasia.deepak@gmail.com
ABSTRACT: Preliminary screening of different crude extract of. M. azedarach was evaluated against human cancer cell lines viz. MCF-7 (breast cancer), SaOS-2 (osteosarcoma), and A431 (epidermoid carcinoma) to search for better herbal based anticancer agent. Solvents used were water, methanol, ethanol, n-butanol, & n-hexane. It has been found that among solvents, methanolic extract of M. azedarach shows comparatively superior activity suggesting presence of phytoconstituents comprising polar functionalities.
How to cite this article: Chowrasia D, Sharma N, Arshad M; In-vitro antiproliferative activity of M. Azedarach; PharmaTutor; 2017; 5(2); 46-49
[ABSTRACT WITH CITATION] [VIEW AS HTML]
REFERENCES:
1.Chowraia, Deepak et. al. Synthesis, characterization and anti cancer activity of some fluorinated 3,6-diaryl-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles; Arabian Journal of Chemistry (2013).
2.Chowrasia, Deepak et. al., Chalcone as a principle pharmacphore for design & development of novel anticancer agents; Pharmacophore, 2016 (5). Accepted
3.WHO fact sheet N 297; Feb.-2015.
4. Skipper HE, Schabel FM, Wilcox Ws.( 1964), Experimental evaluation of potential anti-cancer agents. XIII On the criteria and kinetics associated with ‘curability’ of experimental leukemia. Cancer chemotherapy reports, 1-111.
5.Biemar, F., Foti, M. (2013); Global progress against cancer-challenges and opportunities; Cancer Bio. Med., 10(4); 183-186.
6.Kviecinski MR, Felipe KB, Schoenfelder T, de Lemos Wiese LP. Rossi MH, Gonçalez E, Felicio JD, Filho DW, Pedrosa RC. Study of the antitumor potential of Bidens pilosa (Asteraceae) used in Brazilian folk medicine. J Ethnopharmacol. 2008; 117: 69–75.
7.Reed JC, Pellecchia M. Apoptosis-based therapies for hematologic malignancies.Blood. 2005; 106: 408-418.
8.Yan-Wei H, Chun-Yu L, Chong-Min D, Jian , Wen-Qian, W, Zhen-Lun G. Induction of apoptosis in human hepatocarcinoma SMMC-7721 cells in vitro by flavonoids from Astragalus complanatus. J Ethnopharmacol. 2009; 123: 293–301.
9.Kintzios E. Terrestrial plant-derived anticancer agents and plant species used in anticancer research. Crit Rev Plant Sci. 2006; 25: 79–113.
10.Park HJ, Kim MJ, Ha E, Chung JH. Apoptotic effect of hesperidin through caspase 3 activation in human colon cancer cells, SNU-C4. Phytomedicine. 2008; 15: 147–151.
11.Isman, M.B. Botanical insecticides, deterrents, and repellents in modern agriculture and anincreasingly regulated world. Annu. Rev. Entomol. 2006, 51, 45-66.
12.Akhtar, Y.; Yeoung, Y.R.; Isman, M.B. Comparative bioactivity of selected extracts from Meliaceae and some commercial botanical insecticides against two noctuid caterpillars, Trichoplusia ni and Pseudaletia unipuncta. Phytochem. Rev. 2008, 7, 77-88.
13.Carpinella, C.; Ferrayoli, C.; Valladares, G.; Defago, M.; Palacios, S. Potent limonoid insect antifeedant from Melia Azedarach. Biosci. Biotechnol. Biochem. 2002, 66, 1731-1736.
14Coria, C.; Almiron, W.; Valladares, G.; Carpinella, C.; Ludueña, F.; Defago, M.; Palacios. S. Larvicide and oviposition deterrent effects of fruit and leaf extracts from Melia azedarach L. on Aedes aegypti (L.) (Diptera: Culicidae). Bioresource Technol. 2008, 99, 3066-3070.
15.Kamaraj, C.; Rahuman, A.A.; Bagavan, A.; Mohamed, M.J.; Elango, G.; Rajakumar, G.; Zahir, A.A.; Santhoshkumar, T.; Marimuthu, S. Unit Ovicidal and larvicidal activity of crude extracts of Melia azedarach against Haemonchus contortus (Strongylida). Parasitol. Res. 2010, 106, 1071-1077.
16.Carpinella, M.C.; Giorda, L.M.; Ferrayoli, C.G.; Palacios, S.M. Antifungal effectt of different organic extracts from Melia azedarach L. on phytopathogenic fungi and their isolated active components. J. Agric. Food Chem. 2003, 51, 2506-2511.
17.Carpinella, M.C.; Ferrayoli, C.G.; Palacios, S.M. Antifungal synergistic effect of scopoletin, a hydroxycoumarin isolated from Melia azedarach L. fruits. J. Agric. Food Chem. 2005, 53, 2922-2927.
18.Ntalli, N.G.; Menkisoglu-Spiroudi, U.; Giannakou, I. Nematicidal activity of powder and extracts of Melia azedarach fruits against Meloidogyne incognita. Ann. Appl. Biol. 2010, 156, 309-317.
19.Vishnukanta, A.C.R. Melia azedarach: A phytopharmacological review. Pharmacogn. Rev. 2008, 2, 173-179.
20.Bueno, C.A.; Alché, L.A.; Barquero, A.A. 1-Cinnamoyl-3,11-dihydroxymeliacarpinin delays glycoprotein transport restraining virus multiplication without cytotoxicity. Biochem. Biophys. Res. Commun. 2010, 393, 32-37.
21.Wu, S.B.; Ji, Y.P.; Zhu, J.J.; Zhao, Y.; Xia, G.; Hu, Y.H.; Hu, J.F. Steroids from the leaves of Chinese Melia azedarach and their cytotoxic effects on human cancer cell lines. Steroids 2009, 74, 761-765.
22.Mazumder, M.E.H.; Rahman, S. Pharmacological evaluation of Bangladeshi medicinal plants for antioxidant activity. Pharm. Biol. 2008, 46, 704-709.
23.Ramya S, Jepachanderamohan PJ, Alaguchamy N, Kalayanasundaram M and Jayakumararaj R. In Vitro Antibacterial Prospective of Crude Leaf Extracts of Melia azedarach Linn. against Selected Bacterial Strains. Ethnobot. Leaf. 2009; 13: 254-258.
24.Itharat A, Houghton PJ, Eno-Amooquaye E, Burke PJ, Sampson JH, Raman A. In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer. J Ethnopharmacol. 2004; 90: 33–38.