February 2017 ARTICLE LIST >>
PharmaTutor (February - 2017)
ISSN: 2347 - 7881
(Volume 5, Issue 2)
Received On: 12/09/2016; Accepted On: 14/12/2016; Published On: 01/02/2017
AUTHORS:
Abhijit De 1*, Chandan Ghosh1
1 Department of Pharmaceutical Science,
Bengal School of Technology, Hooghly, West bengal, India
abhi8981@gmail.com
ABSTRACT: Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. In this review, several theories and mechanisms have been put to explain the molecular basis of aging. For example, random damage of the DNA of somatic cell is believed to accumulate with increasing age. Free radicals produced during oxidation of metabolites for energy production also damage DNA and proteins.
How to cite this article: De A, Ghosh C; Basics of aging theories and disease related aging-an overview; PharmaTutor; 2017; 5(2); 16-23
[ABSTRACT WITH CITATION] [VIEW AS HTML]
REFERENCES:
1. Martin G.M., Austad S.N. and Johnson T.E; Genetic analysis of ageing: Role of oxidative damage and environmental stress; Nat. Genet; 1996; 13; 25-34.
2. Davies K.J; Oxidative stress: the paradox of aerobic life; Biochem. Soc. Symp; 1995; 61; 1-31.
3. Martin G.M; Interaction of aging and environmental agents: The gerontological perspective; Prog. Clin. Bio. Res; 1987; 228; 25-80.
4. Gilca M., Stoian I., Atanasiu V. and Virgolici B; The oxidative hypothesis of senescence; J. Postgrad. Med; 2007; 53; 207-213.
5. Harman D; Aging: a theory based on free radical and radiation chemistry; J. Gerontol; 1956; 11; 298-300.
6. Sohal R; Role of oxidative stress and protein oxidation in the aging process; Free. Radic. Biol. Med; 2002; 33; 37-44.
7. Schulz T.J., Zarse K., Voigt A., Urban N., Birringer M. and Ristow M; Glucose Restriction Extends Caenorhabditis elegans Lifespan by Inducing Mitochondrial Respiration and Increasing Oxidative Stress; Cell. Metab; 2007; 6; 280-293.
8. Hagen T.M; Oxidative stress, redox imbalance, and the aging process; Antioxid. Redox. Signal; 2003; 5; 503-506.
9. Yang J.H., Lee H.C., Lin K.J. and Wei Y.H; A specific 4977- bp deletion of mitochondrial DNA in human aging skin; Arch. Dermatol. Res; 1994; 286; 386-390
10. Shammas M.A; Telomeres, lifestyle, cancer, and aging; Cur. Opinion. Clin. Nutr. Metab. Care; 2011; 14; 28–34.
11. Yang Z.W., Huang X., Jiang H., Zhang Y.R., Liu H.X., Qin C. and Eisner G.M; Short telomeres and prognosis of hypertension in a chinese population; Hypertension; 2009; 53; 639–695.
12. Agrawal A., Dang S. and Gabrani R; Recent patents on anti telomerase cancer therapy; Recent. Pat. Anticancer. Drug. Discov; 2012; 7; 102–117.
13. Akbar A.N., Beverley P.L. and Salmon M; Opinion: will telomere erosion lead to a loss of T-cell memory?; Nat. Rev. Immunol; 2004; 4; 737–743.
14. Mitchell J.R., Wood E. and Collins K; A telomerase component is defective in the human disease dyskeratosis congenital; Nature; 1999; 402; 551–555.
15. Katayama K., Armendariz-Borunda J., Raghow R., Kang A.H. and Seyer J.M; A pentapeptude from type I collagen promotes extracellular matrice production; J Biol.Chem; 1993; 268; 9941-9944
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