PharmaTutor (February- 2014)
ISSN: 2347 - 7881
Received On: 29/12/2013; Accepted On: 05/01/2014; Published On: 10/02/2014
Author: Patel Rahul R.*, Kanu R Patel, Mukesh R Patel
Department of Pharmaceutics,
Shri B.M.Shah College of Pharmaceutical Education and Research
Dhansura Road College campus Modasa, Dist:- Arvali. Pin code:- 383315 Gujarat, (India)
rahulpatel21089@gmail.com
ABSTRACT: Micro emulsion based Gel formulation provides better application property and stability & makes it dual control release system in comparison to cream and ointment. Topical Microemulsion based gel drug administration is a localized drug delivery system anywhere in the body through ophthalmic, rectal, vaginal and skin as topical routes. Many advantages of gels a major limitation is in the delivery of hydrophobic drugs. So to overcome this limitation, Microemulsion based approach is being used so that even a hydrophobic therapeutic moiety can enjoy the unique properties of gels. Whenever, it is used for fungal disease for topical delivery system so it is good for compare to oral delivery. When gels and Micro emulsions are used in combined form the dosage form are referred as Microemulsion based gel. Skin is one of the most extensive and readily accessible organs on human body for topical administration and is main route of topical drug delivery system. It is prepared by mixing an oil-in-water type or water-in-oil type emulsion with a gelling agent. The use of Micro emulsion based gels can be extended in analgesics and antifungal drugs.
How to cite this article: RR Patel, KR Patel, MR Patel, Formulation and Characterization of Microemulsion based Gel of Antifungal Drug, PharmaTutor, 2014, 2(2), 79-89
[ABSTRACT WITH CITATION] [VIEW AS HTML]
REFERENCES:
1. Sune B, Folke E, Liisa T.K, Maria R; “Selective enzymatic reactions using microemulsion-based gels.” Colloidal and Surfaces B: Biointerfaces. 1995, 4, 121-127.
2. Joshi B et al; “Emulgel: A Comprehensive Review on the Recent Advances in Topical Drug Delivery.” International Research Journal of Pharmacy. 2011, 2(11), 66-70.
3. Zhu W et al; “Microemulsion-based hydrogel formulation of penciclovir for topical delivery.” International Journal of Pharmaceutics. 2009, 378, 152-158.
4. Sevgi G, Sedef Erdal M, Buket A; “New Formulation Stratagies in Topical Antifungal Therapy.” Journal of Cosmetics, Dermatological Sciences and Application. 2013, 3, 56-65.
5. C Chandran S, Dr Shirwaikar A, Dr Drminic and Devi Sarala A & A; “Development and evaluations of ethosomal formulation containing ketoconazole.” Asian journal of Biomedical and Pharmaceutical Research. 2011, 1(4), 303-309.
6. Dadwal M; “Emulgel: A Novel Approach to Topical Drug Delivery.” International Journal of Pharma and Bio Sciences. 2013, 4(1), 847-856.
7. Mehta K, Bhatt DC; “Preparation, Optimization and In Vitro Microbiological Efficacy of Antifungal Microemulsion.” International Journal of Pharmaceutical Sciences and Research. 2011, 2(9), 2424-2429.
8. Kaur L.P, Guleri T.K; “Topical gel: A Recent Approach for Novel Drug Delivery.” Asian Journal of Biomedical & Pharmaceutical Sciences. 2013, 3(17), 1-5.
9. K.K, M.M.R, Patel D.M, Ganesh NS; “Chemical Permeation Enhancers for Transdermal Drug Delivery: A Brief Review.” Scholars Research Library Der Pharmacia Lettre. 2010, 2(6), 358-365.
10. Alexander A et al; “Recent expansion is an emergent novel drug delivery technology: Emulgel.” Journal of Controlled Release. 2013, 1-11.
11. Singh V, Appala R.S, Ahmad. R, Singh M; “Microemulsions as Promising Delivery Systems: A Review.” Indian Journal of Pharmaceutical Education and Research. 2011, 45(4).
12. Singla V, Saini S, Baibhav J, Rana A; “Emulgel: A New Platform for Topical Drug Delivery.” International Journal of Pharma and Bio Sciences. 2012, 3(1), 485-498.
13. Ritika, L.S H, Aggarwal G; “Microemulsion system in role of expedient vehicle for dermal application.” Journal of drug delivery and therapeutics. 2012, 2(4), 23-28.
14. Drehar F, Walde P, Walthar P, Wehrli E; “Interaction of a lecithin microemulsion gel with human stratum corneum and its effect on transdermal transport.” Journal of Controlled Release. 1997, 45, 131-140.
15. Bhatt. P, Gnanaranjan. G; “Emulgels: A Novel Formulation Approach for Topical Delivery of Hydrophobic Drugs.” International Research Journal of Pharmacy. 2013, 4(2).
16. Sandipan D, Satya K.D; “A novel approach towards transdermal drug delivery system: A precise review.” Indo American Journal of Pharmaceutical Research. 2013, 3(6).
17. Pathan M, Zikriya A, Quazi A; “Microemulsion: An excellent drug delivery system.” International Journal for Pharmaceutical Research Scholors. 2012, 1(3).
18.Majella E. Lane; “Skin Penetration Enhancers.” International Journal of Pharmaceutics. 2013, 447, 12-21.
19. Waghmare N, Waghmare P, Wani S, Yerawar A; “Development of isotretinoin gel for the treatment of acne vulgaris.” Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2011, 2(1), 220-230.
20. Bhowmik D, Gopinath H, Pragati B, Duraivel S; “Recent advances in topical drug delivery system.” The Pharma Innovation. 2012, 1(9), 12-31.
21. Shah R, Magdum C, Wadkar K, Naikwade N; “Fluconazole Topical Microemulsion: Preparation and Evaluation.” Research Journal of Pharmacy and Technology. 2009, 2(2), 353-357.
22. Moghimipour E, Salimi A, Leis F; “Preparation and Evaluation of Tretinoin Microemulsion based on Pseudo-Ternary phase Diagram.” Advanced Pharmaceutical Bulletin. 2012, 2(2), 141-147.
23. Ranga P, Sellakumar V, Natarajan R, Mohan K; “Formulation and In-vitro Evaluation of Ciprofloxacin Loaded Topical Emulgel.” International Journal of Pharmaceutical and Chemical Sciences. 2012, 1(1), 237-242.
24. Patel A, Patel J; “Mucoadhesive Microemulsion Based Prolonged Release Vaginal Gel for Anti-Fungal Drug.” American Journal of Pharma Tech. Research. 2012, 2(4), 650-661.
25. Modi J, Patel J; “Nanoemulsion-Based gel Formulation of Aceclofenac for Topical Delivery.” International Journal of Pharmacy and Pharmaceutical Science Research. 2011, 1(1), 6-12.