AUG 2014 ARTICLE LIST >>
PharmaTutor (August- 2014)
ISSN: 2347 - 7881
(Volume 2, Issue 8)
Received On: 27/05/2014; Accepted On: 20/07/2014; Published On: 01/08/2014
AUTHORS: Tapan Behl*, Ishneet Kaur, Rashi Wanchoo Misri, Heena Goel
Senior Research Fellow, Department of Pharmacology,
Vallbhbhai Patel Chest Institute, University of Delhi, Delhi.
tapanbehl31@gmail.com
ABSTRACT:
Drug delivery and drug targeting systems developed by various researchers are beleaguered to deliver the drug safely to the target sites without much interaction with other tissues of the body, so as to increase its bioavailability and reduce the adverse effects of that drug. In this approach, many drug carriers have been developed which are being widely used these days for increasing the efficacy and safety of the pharmaceutical products. Among the cellular carriers, the erythrocytes are the most potentiated drug carriers with very capitalizing properties like precise site specificity and sustained drug release. The circulation of erythrocytes into every corner of the human body is one such another advantage, thus making them useful for drugs which cannot be taken to their target site by any other carrier. Resealed erythrocytes are prepared by isolating erythrocytes from the plasma of the blood sample of an organism of interest, breakdown of cells using different methods and then entrapping the drug (which is to be administered into the body) into the erythrocytes by various techniques such as hypotonic haemolysis, hypotonic dilution, hypotonic pre-swelling method, dialysis method, isotonic osmocytosis, chemical perturbation of the membrane, electro-insertion method, entrapment by endocytosis, lipid fusion method etc., and then finally they are sealed back again, thus, accounting for their name – “Resealed Erythrocytes”.
How to cite this article: T Behl, I Kaur, RW Misri, H Goel; Resealed Erythrocytes as a Potential Drug Carrier: A Review; PharmaTutor; 2014; 2(8); 73-78
[ABSTRACT WITH CITATION] [VIEW AS HTML]
REFERENCES:
1.Hamidi M. and Tajerzadeh H. Carrier erythrocytes: An overview, Drug Deliv., 2003; 10: 9-20.
2.Rossi L., Serafini S., Pierige F., Antonelli A., Cerasi A., Fraternale A., Chiarantini L. and Magnani M. Eryrthrocyte-based drug delivery Expert Opin. Drug Deliv, 2005; 2: 311-322.
3.Eichler H.G., Ramies H., Bauer K., Korn A., Bacher S. and Gasic S. Survival of gentamicin loaded carrier erythrocytes in healthy human volunteers Eur. J. Clin. Invest, 1986; 16(1): 39-42.
4.Adriaenssens K., Karcher D., Lowenthal A. and Terheggen H.G. Use of enzyme-based loaded erythrocytes in in-vitro correction of arginase-deficient erythrocytes in familial hyperargininemia, Clinical Chemistry, 1976; 22(3): 323-6.
5.Muzykantov V.R. Drug delivery by red blood cells: vascular carriers designed by Mother Nature, Expert Opin. Drug Deliv, 2010; 7(4):403-427.
6.Lewis D.A. and Alpar H.O. Therapeutic possibilities of drugs encapsulated in erythrocytes, Int. J. Pharm., 1984; 22: 137-146.
7.Zimmerman U. Cellular Drug-Carrier Systems and their possible targeting in targeted drugs, E.P. Goldberg (ed.), New York: John Wiley & Sons, 1983; pp. 153-200.
8.Mehrdad H., Adbolhossein Z., Mahshid F. and Soliman M.S. Applications of carrier erythrocytes in delivery of biopharmaceuticals, Journal of Controlled Release, 2007; 118(2): 145-160.
9.Alpar H.O. and Lewis D.A. Therapeutic efficacy of asparaginase encapsulated in intact erythrocytes , Biochem. Pharmacol, 1985; 34: 257-261.
10.Erchler H.G. Gasic S., Bauer K, Korn A. and Bacher S. In vivo clearance of antibody-sensitized human drug carrier erythrocytes , Clin. Pharmacol. Ther, 1986; 40: 300-303.
11.Ihler G.M. and Tsong H.C.W. Hypotonic haemolysis methods for entrapping of agents in resealed erythrocytes , Methods Enzymology, 1987; 149: 221-229.
12.Deloach J.R., Harris R.L. and Ihler G.M. An erythrocyte encapsulator-dialyzer used in preparing large quantities of erythrocyte ghosts and encapsulation of a pesticide in erythrocyte ghosts , Anal. Biochem, 1980; 102: 220-227.
13.Jaitely V., Kanaujia P., Venkatesan N., Jain S. and Vyas S.P. Resealed erythrocytes: drug potentials and biomedical applications , Indian Drugs, 1996; 33: 589-594.
14.Pitt E., Johnson C.M., Lewis D.A., Jenner D.A. and Offord R.E. Encapsulation of drugs in intact erythrocytes: an intravenous delivery system, Biochem. Pharmacol, 1983; 22: 3359-3368.
15.Deloach J.R. and Ihler G.M. A dialysis procedure for loading of erythrocytes with enzymes and lipids, Biochim. Biophys. Acta, 1977; 496: 136-145.
16.Talwar N. and Jain N.K. Erythrocytes as carriers of metronidazole: in-vitro characterization , Drug Dev. Ind. Pharm., 1992; 18: 1799-1812.
17.Jenner D.J., Lewis D.A., Pitt E. and Offord R.A. The effect of the travenous administration of corticosteroids encapsulated in intact erythrocytes on adjuvant arthritis in the rat, Brit. J. Pharmacol., 1981; 73: 212-213.
18.Dale G.L., Villacorte D.G. and Beutler E. High yield entrapment of protein into erythrocytes, Biochem. Med., 1977; 18: 220-225.
19.Klibansky C., PhD, thesis, Hebrew University, Jerusalem, Israel (1959).
20.Zanella A., Rossi F., Sabbioneda L., Russo V., Brovelli A., De Cal F., Fargion S., Fiorelli G. and Sirchia G. Desferrioxamine loading of red cells for transfusion, Adv. Biosci., 1987; 67: 17-27.
21.Deuticke B., Kim M. and Zolinev C. The influence of Amphotericin-B on the permeability of mammalian erythrocytes to non-electrolytes, aniona and cations , Biochim. Biophys. Acta, 1973; 318: 345-359.
22.Kitao T., Hattori K. and Takeshita M. Agglutination of leukemic cells and daunomycin entrapped erythrocytes with lectin in vitro and in vivo, Experimentia, 1978; 341: 94-95.
23.Kinoshita K. and Tsong T.Y. Hemolysis of human erythrocytes by a transient electric field, Proc. Natl. Acad. Sci.,1977; 74: 1923-1927.
24.Schrier S.L., Junga I. and Johnson M. Energized endocytosis in human erythrocyte ghosts, J. Clin. Invest, 1975; 56(1): 8-22.
25.Nicolau C and Gersonde K. Incorporation of inositol hexaphosphate into intact red blood cells I: Fusion of effector-containing lipid vesicles with erythrocytes, Naturwissenschaften, 1979; 66(11): 563-566.
26.Zimmermann U. Jahresberichtder, Kernforschungsanlage, Julich GmcH, Nuclear Research Center, Julich, 1973, pp. 55-58.
27.Jain S., Jain N.K. and Dixit V.K. Erythrocytes based delivery of isoniazid: preparation and in vitro characterization, Indian Drugs, 1995; 32: 471-476.
28.Hamidi M., Tajerzadeh H., Dehpour A.R., Rouini M.R. and Ejtemaee-Mehr S. In vitro characterization of human intact erythrocytes loaded by enalaprilat ,Drug Delivery, 2001; 8: 231-237.
29.Updike S.J. and Wakamiya R.T. Infusion of red blood cell-loaded asparaginase in monkey , J. Lab. Clin. Med., 1983; 101: 679-691.
30.Flynn G., McHale L. and McHale A.P. Methotrexate-loaded photosensitized erythrocytes: A photo-activatable carrier/delivery system for use in cancer therapy, Cancer Lett., 1994; 82(2): 225-229.
31.Chiarantini L., Rossi L., Fraternale A. and Magnani M. Modulated red blood cell survival by membrane protein clustering, Mol. Cell Biochem., 1995; 144(1): 53-59.
.png)
