PharmaTutor (August- 2014)
ISSN: 2347 - 7881
(Volume 2, Issue 8)
Received On: 05/06/2014; Accepted On: 09/06/2014; Published On: 01/08/2014
AUTHORS: V. Sravanthi*, Mayure vijay kumar, G.J.Finny, C.P.Meher
Department of pharmaceutical chemistry, Maheshwara College of Pharmacy
Isnapur chitkul ‘X’ road, Patancheru, Hyderabad-502307
*v.sravanthi27@gmail.com
ABSTRACT:
Cancer is a class of diseases characterized by out-of-control cell growth. Cancer cells damage the body by multiplying their cells uncontrollably to form masses of tissue named as tumor. Tumors cells can grow and interfere with the digestive, nervous, and circulatory systems, and they can release hormones that alter body function. Tumors that are severe to body are called cancerous tumors, and temporary cells that are affected to body are not harmful and called as benign tumors. Nearly 100’s of cancers are known to be effecting the humans. According to this concern the presented review outlines the novel anticancer agents how they are useful, their mechanism, and chemistry has briefly discussed in this article, the main aim of these review is to evaluate the complete novel anticancer drugs under single review paper.
How to cite this article: V Sravanthi, VK Mayure, GJ Finny, CP Meher; Anti-Cancer (Novel Agents): A Review; PharmaTutor; 2014; 2(8); 119-153
[ABSTRACT WITH CITATION] [VIEW AS HTML]
REFERENCES:
1. Hanahan, Douglas; Weinberg, Robert A. "The hallmarks of cancer". Cell 100 January 7, 2000; (1): 57–70.
2. Hanahan, Douglas; Weinberg, Robert A. "Hallmarks of Cancer: The Next Generation" Cell, 2011; 144 (5): 646–74.
3. slideshare.net/intellifarhan390/anti-cancer-drugs-11444757
4. Baylin SB, Ohm JE. "Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?" Nature Reviews Cancer, February 2006; 6 (2): 107–16.
5. UC Davis ChemWiki by University of California
6. Kath R, Blumenstengel K, Fricke HJ, Höffken K. "Bendamustine monotherapy in advanced and refractory chronic lymphocytic leukemia". J. Cancer Res. Clin. Oncol, January 2001; 127 (1): 48–54.
7. Leoni LM, Bailey B, Reifert J, et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res, 2008; 14:309-17.
8. Lesurtel M, Graf R, Aleil B, Walther D, Tian Y, Jochum W, Gachet C, Bader M, Clavien P. "Platelet-derived serotonin mediates liver regeneration", 2006; Science 312 (5770): 104–7.
9. Hall AG, Tilby MJ: Mechanisms of action of, and modes of resistance to, alkylating agents used in the treatment of haematological malignancies. Blood Rev, 1992 Sep; 6(3):163-73.
10. "Carmustine - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. Identification. Retrieved 11 April 2012.
11. Drablos F, Feyzi E, Aas Pa, Vaagbo CB, et al : Alkylating damage in DNA and RNA-Repair mechanisms and medical significance. Dna Repair (Amst), 2004 Nov 2; 3(11): 1389-407.
12. Rai KR, Peterson BL, Appelbaum FR, Kolitz J, Elias L, Shepherd L, Hines J, Threatte GA, Larson RA, Cheson BD, Schiffer CA. "Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia." N Engl J Med, 2000; 343(24): 1750–7
13. Begleiter A, Mowat M, Israels LG, Johnson JB: Chlorambucil in chronic lymphocytic leukemia: mechanism of action. Leuk Lymphoma, 1996 oct; 23(3-4): 187-201.
14. Sistigu A, Viaud S, Chaput N, Bracci L, Proietti E, Zitvogel L. "Immunomodulatory effects of cyclophosphamide and implementations for vaccine design". Seminars in Immunopathology, July 2011; 33 (4): 369–83.
15.fass.se/LIF/produktfakta/audit_page.jsp?_sourcePage=%2Fproduktfakta%2Fartikel_produkt.jsp&docType=7&nplId=19971212000080
16. Lonn U, Lohn S: Prevention of dacarbazine damage of human neoplastic cell Dna b y aphidicolin. Cancer Res, 1987 Jan 1 ; 47(1); 26-30.
17. Jahnke K, Thiel E, Bechrakis NE, et al. "Ifosfamide or trofosfamide in patients with intraocular lymphoma". J. Neurooncol, Dec 2008; 93 (2): 213–7.
18. Dechant KL, Brogden RN, Pilkington T, Faulds D: Ifosfamide/mesna. A review of its antineoplastic activity, pharmacokinetic properties and therapeutic efficacy in cancer. Drugs, 1991 Sep; 42(3):428-67.
19. Facon T, Mary JY, Hulin C, et al. "Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): a randomised trial", October 2007; Lancet 370 (9594): 1209–18.
20. Vasquez KM: Targeting and processing of site-specific DNA interstand crosslinks. Environ Mol Mutagen. 2010 Mar 1
21. "WHO Model List of EssentialMedicines". World Health Organization. October 2013. Retrieved 22 April 2014.
22. Szkudelski T. "The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas." Physiol Res, 2001; 50 (6): 537–46.
23. Malcolm Stevens - interview, Cancer Research UK impact & achievements page
24. Sitbon Sitruk, L.; Sanson, M.; Prades, M.; Lefebvre, G.; Schubert, B.; Poirot, C. "Chimiothérapie a gonadotoxicité inconnue et preservation de la fertilite : Exemple du témozolomide". Gynécologie Obstétrique & Fertilite, 2010; 38 (11): 660–662.
25. "Xeloda (capecitabine) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. 25 January 2014.
26. Pigneux A, Perreau V, Jourdan E, et al. "Adding lomustine to idarubicin and cytarabine for induction chemotherapy in older patients with acute myeloid leukemia: the BGMT 95 trial results". Haematologica, October 2007; 92(10): 1327–34.
27. Perry, Michael J. The Chemotherapy source book. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2008; p. 80.
28. Rossi, S, ed. Australian Medicines Handbook (2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust, 2013.
29. Longley DB, Harkin DP, Johnston PG "5-fluorouracil: mechanisms of action and clinical strategies". Nat. Rev. Cancer, May 2003; 3 (5): 330–8.
30. Rai KR et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med, 2000; 343:1750-7
31. N. M. F. S. A. Cerqueira, P. A. Fernandes, M. J. Ramos "Understanding ribonucleotide reductase inactivation by gemcitabine". Chemistry: A European Journal, 2007; 13 (30): 8507–15.
32. U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894 National Institutes of Health, Health & Human Services
33. McLeod, Howard L.; James Cassidy, Robert H. Powrie, David G. Priest, Mark A. Zorbas, Timothy W. Synold, Stephen Shibata, Darcy Spicer, Donald Bissett, Yazdi K. Pithavala, Mary A. Collier, Linda J. Paradiso, John D. Roberts "Pharmacokinetic and Pharmacodynamic Evaluation of the Glycinamide Ribonucleotide Formyltransferase Inhibitor AG2034".Clinical Cancer Research; Clinical Trials, July 2000; 6 (7): 2677–84.
34. Manegold C "Pemetrexed (Alimta, MTA, multitargeted antifolate, LY231514) for malignant pleural mesothelioma". Semin. Oncol, August 2003; 30 (4 Suppl 10): 32–6.
35. Widemann BC, Balis FM, Godwin KS, McCully C, Adamson PC."The plasma pharmacokinetics and cerebrospinal fluid penetration of the thymidylate synthase inhibitor raltitrexed (Tomudex) in a nonhuman primate model". Cancer Chemother. Pharmacol, 1999; 44 (6): 439–43.
36. Sobell H, "Actinomycin and DNA transcription". Proceedings of the National Academy of Sciences of the United States of America, 1985; 82 (16): 5328–31.
37. Turan T, Karacay O, Tulunay G, Boran N, Koc S, Bozok S, Kose M "Results with EMA/CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine) chemotherapy in gestational trophoblastic neoplasia". Int J Gynecol Cancer, 2006; 16(3): 1432–8.
38. Abd El-Aal H, Habib E, Mishrif M "Wilms' Tumor: The Experience of the Pediatric Unit of Kasr El-Aini Center of Radiation Oncology and Nuclear Medicine (NEMROCK)". J Egypt Natl Canc Inst, 2005; 17 (4): 308–11.
39. Khatua S, Nair C, Ghosh K "Immune-mediated thrombocytopenia following dactinomycin therapy in a child with alveolar rhabdomyosarcoma: the unresolved issues". J Pediatr Hematol Oncol, 2004; 26 (11): 777–9.
40. Jaffe, N.; Paed, D.; Traggis, D.; Salian, S.; Cassady, J. R"Improved outlook for Ewing's sarcoma with combination chemotherapy (vincristine, actinomycin D and cyclophosphamide) and radiation therapy". Cancer, 1976; 38 (5): 1925–1930.
41. Uberti, E. M. H.; Fajardo, M. D. C.; Ferreira, S. V. V. R.; Pereira, M. C. V.; Seger, R. C.; Moreira, M. A. L. R.; Torres, M. D.; De Nápoli, G.; Schmid, H. "Reproductive outcome after discharge of patients with high-risk hydatidiform mole with or without use of one bolus dose of actinomycin D, as prophylactic chemotherapy, during the uterine evacuation of molar pregnancy". Gynecologic Oncology, 2009; 115 (3): 476–481.
42. Lewis, TG; Nydorf, ED "Intralesional bleomycin for warts: a review.". Journal of Drugs in Dermatology, 2006; 5 (6): 499–504.
43. Shaw, P; Agarwal, R "Pleurodesis for malignant pleural effusions". In Shaw, Paul HS. Cochrane Database of Systematic Reviews (1), 2004;
44. Hecht, SM "Bleomycin: new perspectives on the mechanism of action". J. Nat. Prod, 2000; 63: 158–168.
45. G J Quigley, A H Wang, G Ughetto, G van der Marel, J H van Boom, and A Rich "Molecular structure of an anticancer drug-DNA complex: daunomycin plus d(CpGpTpApCpG)". PNAS, December 1980; 77 (12): 7204–7208.
46. Pang B, Qiao X, Janssen L, Velds A, Groothuis T, Kerkhoven R, Nieuwland M, Ovaa H, Rottenberg S, van Tellingen O, Janssen J, Huijgens P, Zwart W, Neefjes J "Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin". Nature Communications, 2013; 4: 1908.
47. Brayfield A, ed."Doxorubicin". Martindale: The Complete Drug Reference. Pharmaceutical Press, 19 December 2013 Retrieved 15 April 2014
48. Pang B, Qiao X, Janssen L, Velds A, Groothuis T, Kerkhoven R, Nieuwland M, Ovaa H, Rottenberg S, van Tellingen O, Janssen J, Huijgens P, Zwart W, Neefjes J "Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin". Nature Communications, 2013. 4 (5): 1908.
49. Bonfante, V; Bonadonna, G; Villani, F; Martini, A "Preliminary clinical experience with 4-epidoxorubicin in advanced human neoplasia".Recent results in cancer research, 1980. 74: 192–9.
50. Pang B, Qiao X, Janssen L, Velds A, Groothuis T, Kerkhoven R, Nieuwland M, Ovaa H, Rottenberg S, van Tellingen O, Janssen J, Huijgens P, Zwart W, Neefjes J "Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin". Nature Communications, 2013. 4: 1908
51. Tomasz, Maria "Mitomycin C: small, fast and deadly (but very selective)."Chemistry and Biology, September 1995. 2 (9): 575–579.
52. Renault, J.; Baron, M; Mailliet P. et al. Heterocyclic quinones 2. Quinoxaline-5,6-(and 5-8)-diones - Potential antitumoral agents. Eur. J. Med. Chem. 1981.16, 6, 545–550,
53. Parker C, Waters R, Leighton C, Hancock J, Sutton R, Moorman AV, Ancliff P, Morgan M, Masurekar A, Goulden N, Green N, Révész T, Darbyshire P, Love S, Saha V "Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial". Lance 2010. t 376 (9757): 2009–2017
54. Mazerski J, Martelli S, Borowski E "The geometry of intercalation complex of antitumor mitoxantrone and ametantrone with DNA: molecular dynamics simulations". Acta Biochim. Pol, 1998; 45 (1): 1–11
55. Hande KR "Etoposide: four decades of development of a topoisomerase II inhibitor". Eur. J. Cancer 1998; 34 (10): 1514–21.
56. Pommier Y, Leo E, Zhang H, Marchand C "DNA topoisomerases and their poisoning by anticancer and antibacterial drugs". Chem. Biol. 2010. 17 (5): 421–33.
57. Gordaliza M, García PA, del Corral JM, Castro MA, Gómez-Zurita MA "Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives". Toxicon, 2004; 44 (4): 441–59.
58. Lyseng-Williamson KA, Fenton C "Docetaxel: a review of its use in metastatic breast cancer". Drugs 2005. 65 (17): 2513–31
59. Yvon AM, Wadsworth P, Jordan MA "Taxol Suppresses Dynamics of Individual Microtubules in Living Human Tumor Cells". Mol. Biol. Cell April 1999; 10 (4): 947–59.
60. Pommier, Y., Leo, E., Zhang, H., Marchand, C.. DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem. Biol. 2010; 17: 421-433.
61. Jordan, MA; Wilson, L "Microtubules as a target for anticancer drugs". Nature reviews. Cancer 2004; 4 (4): 253–65.
62. Ganguly, A; Yang, H; Cabral, F "Paclitaxel-dependent cell lines reveal a novel drug activity".Molecular cancer therapeutics 2010; 9 (11): 2914–23..
63. Lowe, J; Li, H; Downing, KH; Nogales, E "Refined structure of $alpha;$beta;-tubulin at 3.5 p resolution1".Journal of Molecular Biology 2001; 313 (5): 1045–57.
64. Staker, B.L. et al "The mechanism of topoisomerase I poisoning by a camptothecin analog". PNAS 2002; 99 (24): 15387–15392
65. Yang, H.; Ganguly, A.; Cabral, F. "Inhibition of Cell Migration and Cell Division Correlate with Distinct Effects of Microtubule Inhibiting Drugs" (pdf). Journal of Biological Chemistry 2010; 285 (42): 32242–32250.
66. Brayfield, A, ed. "Vincristine". Martindale: The Complete Drug Reference. Pharmaceutical Press. 13 December 2013; Retrieved 15 April 2014.
67. Casanova, M; Ferrari, A; Spreafico, F; Terenziani, M; Massimino, M; Luksch, R; Cefalo, G; Polastri, D et al. "Vinorelbine in previously treated advanced childhood sarcomas: Evidence of activity in rhabdomyosarcoma". Cancer 2002; 94 (12): 3263–8.
68. Wheate NJ, Walker S, Craig GE, Oun R "The status of platinum anticancer drugs in the clinic and in clinical trials". Dalton Transactions September 2010; 39 (35): 8113–27.
69. Praveen D*, Ranadheer Chowdary P, "A review on the use of Bleomycin-Cisplatin-Vinblastine combinations in therapy of testicular cancer" ,Indian Journal of Research in Pharmacy and Biotechnology, IJRPB 1(6) , November – December 2013, 793- 796
70. Graham, Joanne; Mushin, Mohamed; Kirkpatrick, Peter January 2004. "Oxaliplatin". Nature Reviews Drug Discovery 3 (1): 11–2.
71. Los, M.; Roodhart, J. M. L.; Voest, E. E. "Target Practice: Lessons from Phase III Trials with Bevacizumab and Vatalanib in the Treatment of Advanced Colorectal Cancer". The Oncologist 2007; 12 (4): 443–50.
72. Micromedex Healthcare Series [Internet database]. Greenwood Village, Colo: Thomson Healthcare. Updated periodically
73. McClung, Michael R.; Lewiecki, E. Michael; Cohen, Stanley B.; Bolognese, Michael A.; Woodson, Grattan C.; Moffett, Alfred H.; Peacock, Munro; Miller, Paul D. et al. "Denosumab in Postmenopausal Women with Low Bone Mineral Density". New England Journal of Medicine 354 , 2006; (8): 821–31.
74. Raymond E, Faivre S, Armand J "Epidermal growth factor receptor tyrosine kinase as a target for anticancer therapy".Drugs. 2000; 60 Suppl 1: 15–23; discussion 41–2.
75. Takimoto CH, Calvo E. "Principles of Oncologic Pharmacotherapy" in Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (Eds) Cancer Management: A Multidisciplinary Approach. 11 ed. 2008.
76. Deininger MW, Druker BJ "Specific targeted therapy of chronic myelogenous leukemia with imatinib". Pharmacol. Rev. 55, September 2003; (3): 401–23.
77. Vigneri P, Wang JY "Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase". Nat Med. February 2001, 7 (2): 228–34.
78. de Weerd NA, Samarajiwa SA, Hertzog PJ "Type I interferon receptors: biochemistry and biological functions". J Biol Chem, 2007. 282 (28): 20053–20057.
79. Russell-Harde D, Wagnere TC, Perez HD, Cronze E: Formation of a uniguely stable type-1 interferon receptor complex by interferon beta is dependent upon particular interactions between interferon beta and its receptor and independent of tyrosine phosphorylation Biochem Biophys Res Commun. 1999 Feb 16; 255(2): 539-44
80. Antoni Ribas "Tumor immunotherapy directed at PD-1". New England Journal of Medicine, 28 June 2012; 366 (26): 2517–9
81. Dr. Angel Rodriguez "New type of drug shrinks primary breast cancer tumors significantly in just six weeks; research provides leads to a new target in cancer treatment – the cancer stem cell" April 2008.
82. U.S. Food and Drug Administration
83. T Shaw, J Quan, and M Totoritis, "B cell therapy for rheumatoid arthritis: the rituximab (anti-CD20) experience", Ann Rheum Dis. 2003 Nov; 62 (Suppl 2): ii55–ii59.
84. "Prescribing information for Sutent (sunitinib malate)". Pfizer, Inc, New York NY.
85. Bleeding; including serious bleeds such as intracranial and intrapulmonary bleeds
86. Wan, Xiaolin; Shen, Na; Mendoza, Arnulfo; Khanna, Chand; Helman, Lee J. "CCI-779 Inhibits Rhabdo myosarcoma Xenograft Growth by an Antiangiogenic Mechanism Linked to the Targeting of mTOR/Hif-1α/VEGF Signaling". Neoplasia, 2006. 8 (5): 394–401.
87. Moja L, Tagliabue L, Balduzzi S, et al. "Trastuzumab containing regimens for early breast cancer". Cochrane Database Syst Rev 4: 2012.
88. "Breast Cancer Care Trastuzumab factsheet". Breast Cancer Care. Retrieved 22 Oct2013.
89. Ménard, S; Pupa SM, Campiglio M, Tagliabue E "Biologic and therapeutic role of HER2 in cancer". Oncogene 22, 2003; (42): 6570–6578.
90. Weinstein RS, Roberson PK, Manolagas SC "Giant osteoclast formation and long-term oral bisphosphonate therapy". N. Engl. J. Med. Jan 2009; 360 (1): 53–62.
91. Lehenkari PP, Kellinsalmi M, Napankangas JP, Ylitalo KV, Monkkonen J, Rogers MJ, Azhayev A, Vaananen HK, Hassinen IE: Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite. Mol Pharmacol. 2002 May; 61(5):1255-62
92. "boniva". The American Society of Health-System Pharmacists. Retrieved 3 April 2011.
93. Epstein S, Zaidi M: Biological properties and mechanism of action of ibandronate: application to the treatment of osteoporosis. Bone. 2005 Oct; 37(4):433-40.
94. Zarychanski R, Elphee E, Walton P, Johnston J "Osteonecrosis of the jaw associated with pamidronate therapy." Am J Hematol 81, 2006; (1): 73–5.
95. Aclasta label- Australia
96. Simpson ER "Sources of estrogen and their importance". The Journal of Steroid Biochemistry and Molecular Biology86, 2003; (3–5): 225–30.
97. "FDA approves Zytiga for late-stage prostate cancer"(Press release). Food and Drug Administration (FDA). 2011-04-28.
98. Attard G, Belldegrun AS, de Bono JS "Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer". BJU Int. Dec 2005; 96 (9): 1241–6.
99. Kouvaris JR, Kouloulias VE, Vlahos LJ "Amifostine: the first selective-target and broad-spectrum radioprotector". Oncologist June 2007; 12(6): 738–47
100. Brunton, L; Chabner, B; Knollman, B Goodman and Gilman's The Pharmacological Basis of Therapeutics (in English) (12th ed.). New York: McGraw-Hill Professional. 2010.
101. Furr BJ "The development of Casodex (bicalutamide): preclinical studies". Eur. Urol. 1996; 29 Suppl 2, 83–95.
102. asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=114&abstractID=94715
103. Kirby RS, Fitzpatrick JM, Clarke N: Abarelix and other Gonadotrophin-releasing hormone antagonists in prostate cancer. BJU Int. 2009 Dec; 104(11): 1580-4
104. Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 289. Retrieved 29 May 2012.
105. Stadtler FA, Langner V: The effect of cyproterone and gonadotrophins on the adrenal gland of juvenile and adult rats. A morphological and morphometrical study. Pathol Res Pract. 1985 Mar; 179 (4-5):493-8.
106. Princivalle M, Broqua P, White R, et al Rapid suppression of plasma testosterone levels and tumor growth in the dunning rat model treated with degarelix, a new gonadotropin-releasing hormone antagonist. J. Pharmacol. Exp. Ther. Mar 2007. 320: 1113-8.
107. Persson BE, Kold Olesen T, Jensen JK: Degarelix: a new approach for the treatment of prostate cancer. Neuroendocrinology.2009; 90(3):235-44. Epub 2009 Jul 14.
108. Aromasin For Advanced Breast Cancer
109. Robinson A: A review of the use of exemestane in early breast cancer. Ther Clin Risk Manag. 2009 Feb; 5(1):91-8. Epub 2009 Mar 26.
110. Scher, Howard I. "Hyperplastic and Malignant Diseases of the Prostate". In Dennis L. Kasper, Anthony S. Fauci, Dan L. Longo, Eugene Braunwald, Stephen L. Hauser, & J. Larry Jameson (Eds.), Harrison's Principles of Internal Medicine (16th edition), New York: McGraw-Hill. 2005. pp. 548–9.
111. Jack Lawrence James, Louis Frank Molnar, Jr., Tania E. Toney-Parker, “Processes for preparing flutamide compounds and compounds prepared by such processes.” U.S. Patent US 6,228,401, issued Nov, 1976.
112. Ellis JM, Tan HK, Gilbert RE, et al ."Supplementation with antioxidants and folinic acid for children with Down's syndrome: randomised controlled trial". BMJ 336 (7644): 594–7. Mar2008.
113. Angela Mae Obermiller, PharmD; and Mehmet Sitki Copur, MD "The Longstanding Quest for a Better Endocrine Therapy Continues High-Dose Fulvestrant: Have We Found Its Effective Dose, Combination, Setting, or Sequence?".Contemporary Oncology, 2011. 3 (1).
114. Kabos P, Borges VF: Fulvestrant: a unique antiendocrine agent for estrogen-sensitive breast cancer. Expert Opin Pharmacother. 2010 Apr;11(5):807-16
115. FDA Approval for Zoladex 3.6 mg
116. Kripa S. Srivastava, Matthew R. Davis, “Solid Phase Peptide for the Production of Goserelin.” U.S. Patent US20100311946, issued Dec 09, 2010.
117. "FDA Approves New Drug to Treat Rare Disease, Acromegaly" (Press release). U.S. Food and Drug Administration. August 30, 2007. Retrieved 2007-09-06.
118. Tercica. SOMATULINE product monograph. Brisbane, California; 1 Aug 2007
119. Vallet S, Palumbo A, Raje N, Boccadoro M, Anderson KC "Thalidomide and lenalidomide: Mechanism-based potential drug combinations". Leukemia & Lymphoma, July 2008. 49 (7): 1238–45.
120. Haberfeld, H, ed. (Austria-Codex (in German) (2009/2010 ed.). Vienna: Osterreichischer Apothekerverlag. 2009.
121. Badaru A, Wilson DM, Bachrach LK, et al. "Sequential comparisons of one-month and three-month depot leuprolide regimens in central precocious puberty". The Journal of Clinical Endocrinology and Metabolism May 2006. 91 (5): 1862–7.
122. Schindler AE, Campagnoli C, Druckmann R, Huber J, Pasqualini JR, Schweppe KW, Thijssen JH: Classification and pharmacology of progestins. Maturitas. 2008 Sep-Oct; 61(1-2):171-80.
123. Pascual Lopez A, Roque i Figuls M, Urrutia Cuchi G, Berenstein EG, Almenar Pasies B, Balcells Alegre M, Herdman M: Systematic review of megestrol acetate in the treatment of anorexia-cachexia syndrome. J Pain Symptom Manage. 2004 Apr; 27(4):360-9.
124. "WHO Model List of EssentialMedicines". World Health Organization. October 2013. Retrieved 22 Apr 2014.
125. Lustig RH, Hinds PS, Ringwald-Smith K, Christensen RK, Kaste SC, Schreiber RE, Rai SN, Lensing SY, Wu S, Xiong X "Octreotide therapy of pediatric hypothalamic obesity: a double-blind, placebo-controlled trial". J. Clin. Endocrinol. Metab. June 2003. 88 (6): 2586–92.
126. Ruan W, Fahlbusch F, Clemmons DR, Monaco ME, Walden PD, Silva AP, Schmid HA, Kleinberg DL: SOM230 inhibits insulin-like growth factor-I action in mammary gland development by pituitary independent mechanism: mediated through somatostatin subtype receptor 3? Mol Endocrinol. 2006 Feb; 20(2):426-36. Epub 2005 Oct 13.
127. Dutton DB Worse than the disease: pitfalls of medical progress. Cambridge: Cambridge University Press, 1988.
128. Baron S, Escande A, Alberola G et al,: estrogen receptor alpha and the activating protein-1 complex cooperate during insulin-like growth factor-I-induced transcriptional activation of the pS2/TFF1 gene. J Biol Chem. 2007 Apr 20; 282 (16): 11732-41 Epub 2007 Feb 22
129. USA (2012-10-19). "Tamoxifen treatment of pr... [J Pediatr Endocrinol Metab. 1999 Sep-Oct] - PubMed - NCBI". Ncbi.nlm.nih.gov. Retrieved 2013-01-06.
130. Osborne CK, Bardou V, Hopp TA, Chamness GC, Hilsenbeck SG, Fuqua SA, Wong J, Allred DC, Clark GM, Schiff R, "Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer". J. Natl. Cancer Inst. March 2003. 95 (5): 353–61
131. Franks ME, Macpherson GR, Figg WD "Thalidomide". Lancet, May 2004.363 (9423): 1802–1811.
132. D'Amato RJ, Loughnan MS, Flynn E, Folkman J "Thalidomide is an inhibitor of angiogenesis". Proceedings of the National Academy of Sciences of the United States of America 1994, 91 (9): 4082–4085
133. Lahlou N, Carel JC, Chaussain JL, Roger M "Pharmacokinetics and pharmacodynamics of GnRH agonists: clinical implications in pediatrics". J Pediatr Endocrinol Metab. July 2000. 13 Suppl 1: 723–37.
134. Product Information: Trelstar Depot, triptorelin pamoate. Pharmacia & Upjohn, Kalamazoo, MI, PI reviewed 09/2000.
135. Magnol JP, Achache S. Cancerologie vétérinaire et comparée. Maloine Editeur; Paris: 1983.
136. Mc Knight JA, Mauldin GN, Mc Entee MC, Meleo KA, Patnaik AK. Radiation treatment for incompletely resected soft – tissue sarcomas in dogs. J. Am. Vet. Med. Assoc. 2000; 217 (2):205–210.
137. Theilen GH, Madewell BR, Carter SK. Chemotherapy. In: Theilen, Madewell, editors. Veterinary Cancer Medicine. Lea & Febiger; Philadelphia: 1987a. pp. 157–166.
138. Dewhirst MW. Hyperthermia. In: Theilen, Madewell, editors. Veterinary Cancer Medicine. Lea & Febiger; Philadelphia: 1987. pp. 197–214.
139. Hetzel FW. Phototherapy. In: Theilen, Madewell, editors. Veterinary Cancer Medicine. Lea & Febiger; Philadelphia: 1987. pp. 215–218.
140. Theilen GH, Madewell BR. Clinical Applications of Cancer Chemotherapy. In: Theilen, Madewell, editors. Veterinary Cancer Medicine. Lea & Febiger; Philadelphia: 1987a. pp. 183–196.
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