Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support. At Pfizer, colleagues in more than 90 countries work every day to help people stay happier and healthier longer and to reduce the human and economic burden of disease worldwide.
Post : Senior Scientist, Clinical Cell-Based Assays
Role Summary
• Senior scientist position is within the Clinical & Diagnostics Assay Development (CDAD) group within Pfizer Vaccine Research in La Jolla, CA.
• The incumbent will provide flow cytometry and cell-mediated immunity (CMI) based immunological support for Pfizer’s vaccines programs. This will entail the development and implementation of complex flow cytometry experiments utilizing established and novel procedures. Additionally, the incumbent will lead the development and optimization of assays to characterize CMI responses to vaccines.
• This position is responsible for supporting clinical development of vaccine programs by qualifying clinical assays fit-for-use for assessment of immune responses in phase 1/2 clinical trials, and also for the conduct of cell-based assays on samples acquired as part of early-stage clinical trials.
• This position requires an in-depth technical knowledge of multi-parameter Flow Cytometry using the Becton Dickenson platform, as well as an understanding of relevant software including FACS Diva and FlowJo.
• The role also includes conducting tasks required to operate a GCLP compliant laboratory that may include maintenance of equipment, reagent sourcing and/or activities relating to compliance (such as document management).
• Experience of working in a BSL2 level tissue culture laboratory is required.
• Requires a colleague with good analytical skills, attention to detail and a basic understanding of statistics, as well as ability to clearly document and present complex biological data.
• The incumbent is accountable to line management and project leadership.
Role Responsibilities
• Oversee a flow cytometry laboratory.
• Lead the design, development and qualification/validation of flow cytometry-based clinical immune assays to evaluate cell mediated immune responses in support of various vaccine clinical programs.
• Interpret data and draw final conclusions regarding progress and results of work. Present progress to senior management and project leadership. Write reports for internal communications as well as complete scientific papers for peered review journals. Required to present original research at internal seminars and external scientific meetings.
• Conduct cell-based immunoassays on clinical samples in accordance with GCLP requirements.
• Exhibits exceptional professional maturity as exemplified by promoting interaction within and outside of group and a proven ability to train scientific staff in laboratory techniques.
• Read scientific and technical literature in order to bring new and improved procedures to the laboratory, and to broaden understanding of disciplines outside area of training. Utilizes all appropriate experimental design methods needed for pharmaceutical industry work in area of specialization.
• Act as the technical lead for the flow cytometry team by maintaining flow cytometers, reagents and associated analytical platforms and software to achieve clinical compliance.
• Support the efficient and compliant operation of the laboratory by developing appropriate processes and standard operating procedures and working with others to operate the laboratory.
• Directly manage work of at least 1 scientist and indirect management of additional scientists through matrix relationship.
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Candidate Profile
• PhD with 2+ (preferred) or Masters with 7+ years of relevant work experience.
• A background in immunology and cell-based assay development.
• Expertise in multi-parameter flow cytometry using the Becton Dickenson platform.
• Experience of working in an industrial laboratory with a defined quality system.
• Experience with tissue culture and working with human samples under aseptic conditions.
• Strong verbal and written communication and presentation skills in English are required.
• Proficiency in all common office including word processing, spreadsheets, PowerPoint and relevant scientific software is required.
• Strong ability to multi-task and work efficiently and productively in a fast-paced and highly collaborative environment.
• Experience of applying automated systems to complex biological assay applications.
• Experience in the implementation and use of laboratory information management systems.
• Knowledge of clinical serological assays or ELISPOT assay.
• Experience in managing scientists is preferred but not required.
Additional Information
Qualification : Ph.D
Industry Type : Pharma
Location : USA - CA - La Jolla
Functional Area : Clinical Cell-Based Assays
End Date : 15th May, 2018
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