Pharmacognosy Articles

ABOUT AUTHORS
Mudasir Maqbool¹*, Mohmad Amin Dar¹, Shafiqa Rasool¹, Rabiah Bashir1, Misba Khan ^2
1Department of Pharmaceutical Sciences,
University of Kashmir, Hazratbal Srinagar, Jammu and Kashmir, India
²Mader-E-Meharban Institute of Nursing Sciences and Research,
Jammu And Kashmir, India

ABSTRACT
The maintenance of a healthy liver is vital to overall health of the human beings. Since the liver is involved in almost all biochemical processes and there are many different diseases that will affect it. The liver is often abused by environmental toxins, which are eating habits, alcohol and overdose of certain drugs which can damage and weaken the liver and eventually lead to many diseases. Medicinal herbs are significant source of hepatoprotective drugs. Mono and poly-herbal preparations have been used in various liver disorders. According to one estimate, more than 700 mono and poly-herbal preparations in the form of decoction, tincture, tablets and capsules from more than 100 plants are in clinical use. From the literature review near about 178 medicinal plants are reported to possess a hepatoprotective activity. A drug having beneficial effect on the liver is known as hepatoprotective drug. On the other hand, drugs having toxic effect on the liver are better known as hepatotoxic drugs. The most commonly used parameters to assess the hepatoprotective activity are morphological e.g. Liver weight and volume, biochemical estimations, such as measurement of transaminase activity, SGPT, SCOT, alkaline phosphatase, serum bilirubin, total serum proteins, albumin, globulin and prothrombin time, functional parameters, pentobarbitone and hexobarbitone sleeping time and finally histopathological study regarding presence of necrosis, fatty degeneration and cirrhosis. In this review, we will briefly discuss hepatotoxicity and hepatoprotective agents.

{ DOWNLOAD AS PDF }

ABOUT AUTHORS
Mir Sahidul Ali*¹, Souvik Mukherjee², Subhajit Makar², Gargi Pal³
*¹Department of Chemical and Polymer Engineering,
Tripura University, Suryamaninagar, Tripura, India
²Centre for Pharmaceutical Sciences &
Natural Products, School of Basic and Applied Sciences,
Central University of Punjab, Bathinda, Punjab, India
³Department of Pharmaceutical Sciences and Technology,
NSHM Knowledge Campus, Kolkata, India.

ABSTRACT:
Cucurbitacins which are structurally unlike triterpenes found in the members of Cucurbitaceae and several other plant families possess immense pharmacological activity. This diverse group of compounds may substantiate to be important lead molecules for the treatment of cancer. Research focused on these unattended medicinal compound can prove the significance and explore the hidden potential to cure various diseases. These compounds shows their proposed mode of action, probable molecular targets and have future aspects of their use as a medicinal agent. This review is aimed to provide the chemical nature and medicinal property of cucurbitacins.

{ DOWNLOAD AS PDF }

ABOUT AUTHORS
Patil N.B.*, Patil K.B., Wagh M.N., Patil A.A,
Department of Pharmacy, Ahinsa Institute of Pharmacy,
Dondaicha, Maharashtra, India

ABSTRACT
The methanol extract of murraya koenigii (leaf) were investigated for their antibacterial activity against staphylococcus aureus using cup plate agar diffusion method and methanol extract produces best results. various investigation like physiochemical standard ,preliminary phytochemical screening of the plant was carried out and parameter were reported. The present paper deals with investigation of various phytochemical present in methanol extract and in vitro antibacterial activity against the s.aureus .the literature survey does not exist anti bacerial activity of murraya koenigii (leaf) in methanol extract against s.aureus.it is concluded that the plant studied may source of antibacterial plant.

{ DOWNLOAD AS PDF }

ABOUT AUTHOR
Patil N.B.
Department of Pharmacy, Ahinsa Institute of Pharmacy,
Dondaicha, Maharashtra

ABSTRACT
This study reports the surveyed of medicinal plants used by village peoples of satpuda hills in shirpur taluka in ethno veterinary practices during this study ,information about ethno veterinary plants was obtained from villages peoples of personal meet them and collect the information .the ethno veterinary plants were collected and preserved as herbarium specimens by follows the standard methods.the identification of plants on botany department of R.C.Patel shirpur,Maharashtra.during the survey it was noted that 12 plants were traditionally used by treat various veterinary diseases such as  Inflammation, wound healing, Indigestion , Dysentry, Diarrhoea, Infertility, Afra disease, Infection of uterus, antimicrobial.

The information provided in this study would bring new medicine development of ecofriendly, effective medicines to control veterinary disease in the future prospective.this study may be useful to protect and conserve the endemic flora species of satpuda hills of shirpur taluka (Dist-Dhule,Maharashtra).

ABOUT AUTHORS
Diksha A. Narwade*, Dr. A. N. Aher
Department of Pharmacognosy,
MVP samaj college of pharmacy,
Gangapur road Nashik, Maharastra, India
{ DOWNLOAD AS PDF }

ABSTRACT
This paper gives the information about the Annona squamosa Linn. (Family: Annonaceae). Phytochemical and pharmacological studies of medicinal plant were performed. The plant is highly used traditionally for curing diverse diseases and disorders. It is locally known as “Sitaphal'' in Hindi. Macroscopical & microscopical studies of leaves have been studied. The phytochemical studies showed the presence of amino acids, terpenes, lipids, steroids, flavonoids, ascorbic acid, tannins, vitamins and alkaloids. The plant has various pharmacological actions such as insecticidal, purgative, laxatives, astringent, anti-inflammatory, antidiabetic, anti-ulcer, anti-oxidant, antimalarial and antibacterial. The reveiw specifically deals with the phytochemical and folkloric medicinal importance of plant.

{ DOWNLOAD AS PDF }

ABOUT AUTHORS
Kajal V. Kosankar*, Dr. A.N. Aher
MVP samaj college of pharmacy, Gangapur road Nashik, Maharashtra, India

ABSTRACT
Ficus racemosa it belongs to family Moraceae syn. Ficus glomerata Roxb. is the major group of angiosperm (flowering plant). They are widely distributed throughout Asia, Africa, America, Australia, Himalayan ranges, Punjab, Khasia Mountain, Bihar, Orissa, Rajasthan, Deccan, China, Indonesia and Malaysia. Udumber is used from ancient time for treating the many diseases. This tree is used traditionally for public health. It is also called yajnodumbara and grows all over the India at different areas. The common name is ‘Audumbar’ and ‘Umbar’ and used in Unani, Ayurveda and Homeopathy. The leaves tender are used in kalasha prokshana it is sprinkle water to different places from a scared copper mug and the bark is used in Homa. In review macroscopically studies, microscopically studies and chemical constituents are studied on different parts of the plant. Traditional uses and pharmacological uses are described, the extraction of leaves, fruit, stem, bark and latex are done due to this the important constituents are isolated in respective solvent like ethanol, methanol, acetone, petroleum ether, ethyl acetate and water. The more information is described below and the people are moving towards ayurvedic preparations.

{ DOWNLOAD AS PDF }

ABOUT AUTHORS
Mir Sahidul Ali¹, Souvik Mukherjee², Debayan Roy², Gargi Pal³, Subhajit Makar*^2
1Department of Chemical & Polymer Engineering, Tripura University (A Central   University), Suryamaninagar, Tripura 799022, India.
²School of Basic & Applied Sciences, Central University of Punjab,Bathinda-155110, Punjab, India.
³ Department of Pharmaceutical Sciences and Technology, NSHM Knowledge Campus, Kolkata- 700053, India.

ABSTRACT: Asparagus racemosus (A. racemosus) is a well-known medicinal plant due its various application in Ayurveda. It contains various type of secondary metabolite active natural products (or ingredients) such as steroids, alkaloids, flavonoids, furan derivatives and essential oils. In the present scenario due to growing catastrophic effect of diseases in human life, researchers are trying to stop synthetic drugs by replacing with herbal drugs. Herbal drug treatments are in general used to provide first-line and public health provider, both to persons abode in faraway areas the place it is the only on hand wellness service, and to people residing in bad areas the place it offers the one cheap relief. In this point of view A. racemosus can show a new path of herbal treatment.

{ DOWNLOAD AS PDF }

ABOUT AUTHORS
R. Mishra¹, P. Barad¹, N. Patel², N. Patel³*
¹Department of Pharmacy,
Shree S.K. Patel College of  Pharmaceutical  Education & Research
Ganpat University, Kherva, Mehasana Gujarat
²Department of Pharmacognosy,
Shree S.K. Patel College of  Pharmaceutical  Education & Research
Ganpat University, Kherva, Mehasana Gujarat
³Department of Pharmacology,
Shree S.K. Patel College of  Pharmaceutical  Education & Research
Ganpat University, Kherva, Mehasana Gujarat

ABSTRACT
Worldwide cancer is the major cause of death. Almost 8.8 million people died due to different types of cancer such as lung cancer, liver cancer, breast cancer, stomach cancer, blood cancer etc. in 2015. Government of various countries and some private organizations are spending trillions dollars for the research in cancer.  According to report of WHO treatment cost of cancer is approximately US$ 1.16 trillion per year and this amount is increasing per year. Despite of huge work the exact cause of genesis is still unknown. Couples of therapies like chemotherapy, radiation, surgery and targeted therapy are available with some detrimental effect. Now scientists are seeking lead molecule from naturally occurring substances due to high safety margin as compared to current approaches. Natural phytochemicals are prominent strategy for prevention, treating, and curing cancer. There are many phytochemicals from herbs having potent anticancer property. Generally these phytochemicals treat cancer by different mechanisms like augmenting apoptosis, cell cycle arrest, targeting to some specific cancer inducing proteins, increasing cytotoxicity etc. This is our little attempt to gather information of phytochemicals having anticancer property such as Etoposide, Curcumin, Vincristine, etc. with postulated mechanism. Etoposide is effective in lung cancer, ovarian cancer by inhibiting type II Topoisomerase. Various research revealed that Curcumin is effective in different types of cancers by increasing apoptosis and targeting specific gene such as MDM2 oncogene is inhibited through the ETS2 transcription factor by modulation of signaling pathway PI3K/mTOR in breast cancer. Vincristine shows anticancer property by oncogenic EWS-FLI1 fusion protein inhibition which cause G2-M phase cell cycle arrest & reduce tumor. This review depicts few phytochemicals having anticancer property such as Etoposide, Curcumin, vincristine, etc. with possible mechanism.