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June 2020

 

 

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Corona virus disease-2019 (COVID-19) : The epidemic and the challenges

ABOUT AUTHORS :
Disha Chouhana*1, Dr. Rajesh Mujariya2
1*Department of Pharmaceutical Chemistry, School of Pharmaceutical Science and Research , Balaghat, Madhya Pradesh, India
2Department of Pharmaceutics,  School of Pharmaceutical Science and Research , Balaghat, Madhya Pradesh, India
rajeshmujariya@gmail.com

ABSTRACT :
There is a new public health crises threatening the world with the emergence and spread of 2019 novel corona virus (2019-nCoV) or the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). The virus originated in bats and was transmitted to humans through yet unknown intermediary animals in Wuhan, Hubei province, China in December 2019. There have been around 96,000 reported cases of corona virus disease 2019 (COVID-2019) and 3300 reported deaths to date (05/03/2020). The disease is transmitted by inhalation or contact with infected droplets and the incubation period ranges from 2 to 14 d.

Five tips on how to live with novel coronavirus

After seventy days of lockdown, the unlock 1.0 is put into action. Officially designated lockdown 5.0, from June 1, 2020, the economy and ordinary life are returning to normalcy in a controlled and phased manner. This is the beginning of a new normal. It is going to be a long haul. Experts and officials are suggesting that ‘we must learn to live with the virus’. With vaccine still months away, we need to live in a new normal. Speaking to India Science Wire, Prof. K Vijay Raghavan, Principal Scientific Advisor to the Government of India, gave five tips to ‘living with the virus’.

The fight against Chikungunya disease has got a major boost with CEPI, the global Coalition for Epidemic Preparedness Innovations, and its Indian arm Ind-CEPI, announcing a new partnering agreement with a consortium comprising Hyderabad-based Bharat Biotech (BBIL) and the International Vaccine Institute (IVI) to promote the development of a vaccine against the disease.

AGC Biologics, a global biopharmaceutical Contract Development and Manufacturing Organization (CDMO), has announced that it will partner with Novavax, Inc. (NASDAQ: NVAX), a late-stage biotechnology company developing next-generation vaccines for serious infectious diseases, on large-scale GMP production of a critical component of Novavax’ coronavirus vaccine candidate, NVX-CoV2373. AGC Biologics will manufacture Matrix-M™, the adjuvant component of the vaccine, in order to enhance the immune response and stimulate high levels of neutralizing antibodies.

NVX-CoV2373 is a stable, prefusion protein made using Novavax’ proprietary nanoparticle technology. AGC Biologics will optimize process development for scaled-up production of Matrix-M to significantly increase Novavax’ capacity to deliver doses in 2020 and 2021.

“We are quickly ramping up to successfully deliver this vital vaccine component to Novavax,” says AGC Biologics’ CEO Patricio Massera. “The urgency to help produce a vaccine to combat COVID-19 could not be higher.”


“AGC Biologics’ mission is to work side-by-side with our partners to produce life-saving and extending products,” says Mark Womack, CBO of AGC Biologics. “Partnering with Novavax to manufacture this vaccine component is an amazing opportunity to make a profoundly positive difference.”

“We have been impressed with AGC Biologics’ level of collaboration and commitment,” says Timothy J. Hahn, SVP, Process Technology at Novavax. “They are an important strategic partner in expanding our supply chain of adjuvant for NVX-CoV2373 and for other vaccines being developed at Novavax, including our recombinant seasonal influenza vaccine, NanoFlu.”


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