February 2019

Piramal Enterprises Limited is the flagship company of the Piramal Group.  Starting from the mid-1980s, PEL has shifted its focus from the textiles industry, and established its entrepreneurial credentials in Pharma, Information Management, and Financial Services. It has grown organically and inorganically and often made contrarian business calls.  When Indian pharmaceutical industry was focused on international generics, we invested in domestic formulation businesses.

Post : Manager - Strategy and Market Intelligence

Zoetis is a global animal health company dedicated to supporting customers and their businesses in ever better ways. Building on 60 years of experience as Pfizer Animal Health, we deliver quality medicines and vaccines, complemented by diagnostics products and genetics tests and supported by a range of services. We are working every day to better understand and address the real-world challenges faced by those who raise and care for animals in ways they find truly relevant.

Post : Executive - Supply Chain & Logistics

IIT (BHU) is an Institute of national importance created by an Act of the Parliament through the Institutes of Technology (Amendment) Act, 2012 vide Gazette Notification dated 29.06.2012. All the IITs are administered centrally by the IIT Council, an apex body established by the Government of India. The Minister of Human Resource & Development, Government of India, is the Chairman of the Council.

Post : Senior/Junior Research Fellow

National Dope Testing Laboratory (NDTL), an Autonomous Body under the aegis of Ministry of Youth Affairs and Sports (Department of Sports), GOI, J N Stadium Complex, Lodhi Road, New Delhi – 110 003 invites applications from suitable candidates to fill up One post of Scientist “D” in Pay Rs. 78,800/- in Pay Level 12 as per 7th CPC on Deputation/Transfer failing which by Direct Recruitment and Three Posts of Scientist ‘B’ in Pay Rs. 56100/- in Pay Matrix Level 10 as per 7th CPC for Direct Recruitment.

District Health Society, Sahibganj, Department of Health & Family Welfare, Government of Jharkhand invites application from suitable candidates for the following positions for District Health Society, Sahibganj.

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ABOUT AUTHORS
Aliyu Hamidu Ahmed¹, Yusuf Ibrahim Alkali^2
1Department of Pharmacognosy and Ethno pharmacy, Faculty of Pharmaceutical Sciences
Usmanu Danfodiyo University, Sokoto- Nigeria
²Department of Pharmacology and Toxicology, Usmanu Danfodiyo University, Sokoto- Nigeria.

ABSTRACT
Pharmacokinetics and toxicity profile along with efficacy are the major determinants for successful drug development. This study was carried out to determine the pharmacokinetic profile, potential biological activities and toxicity of diospyrin, lupeol and plumbagin using in silico approaches. The Swiss ADME tool was used to calculate the molecular properties of the ligands based on Lipinski’s rule of five (5).All ligands in the present study satisfied the rule. Using the Swiss ADME tool, the pharmacokinetic profile of the compounds was evaluated. Protox-II server was used to predict the organ toxicities and toxicological end points of the ligands and their LD50. Plumbagin is found to have both mutagenicity and carcinogenicity. Lupeol and diospyrin are reported to be immunotoxic. Lupeol has LD50 of 2000mg/kg. Diospyrin and plumbagin have 16mg/kg. Swiss target prediction server was used to identify the various potential target. The target prediction suggests that plumbagin and lupeol have high preference for Microtubule-associated protein tau (MAPT). The best target for diospyrin was Aurora kinase A. Molecular docking study was conducted using AutoDock vina in The Python Prescription (PyRx) 0.8 virtual screening tool.  Plumbagin and lupeol were docked against Microtubule associated protein tau. The dockings scores based on binding energy were; plumbagin -33.8 (kcal/mole) and lupeol -44.7 (kcal/mole). Diospyrin showed a binding energy of -10.7 (kcal/mole) against Aurora A kinase. Results in this study suggest that diospyrin may serve as an important aurora kinase inhibitor while lupeol and plumbagin may be useful in treatment of Alzheimer’s disease.

The CSIR-National Botanical Research Institute (NBRI) - is amongst one of the constituent research institutes of the Council of Scientific and Industrial Research (CSIR), New Delhi. Originally set up as the National Botanic Gardens (NBG) by the State Government of Uttar Pradesh (U.P.), it was taken over by the CSIR in 1953. Though, initially engaged in research in the classical botanical disciplines, the NBG went on laying an increasing emphasis, in keeping with the national needs and priorities in the field of plant sciences, on its applied and developmental research activities. A time came when it was felt that the name NBG no longer projected the correct nature and extent of its aims and objectives, functions and R & D activities.