October 2018

Mohalla Clinics are primary health centres in the state of New Delhi in India, that offer a basic package of essential health services including medicines, diagnostics, and consultation free of cost. Mohalla in Hindi means neighborhood or community. These clinics serve as the first point of contact for the population, offer timely services, and reduce the load of referrals to secondary and tertiary health facilities in the state. Mohalla Clinics was first set up by the Aam Admi Party government in 2015, and as of 2018, 187 such clinics have been set up across the state and served more than 2 million residents. The Government has kept a target of setting up 1000 such clinics in the city before 2020 Delhi Legislative Assembly Elections. According to the World Health Organization data for the year 2015, more than 65% of the population in India paid for health from their own pockets.

NIPER is the fifth Institute to be included in the list of premier Institutes under the Department of  Pharmaceuticals, Ministry of Chemicals & Fertilizers, Govt. of India. The NIPER started functioning  from the month of September, 2008.  The Institute is presently housed at the NIPS, Mirza, Kamrup, Assam. The  Institute has excellent facilities for advanced Education and Research in Pharmaceutical Sciences and is looking  for Project/Non Teaching Staff with good experience to contribute in building this Institute as one of the best  Centers for Excellence. Presently the Institute is offering M.S (Pharm.) and Ph. D Programmes in five branches  and planning to expand further.

The Tata Memorial Centre (TMC) is a Comprehensive Cancer Centre with a mission to achieve the highest standards in patient care, cancer prevention, cancer research and professional development for oncology and allied disciplines. TMC is an autonomous body funded, controlled by the Department of Atomic Energy, Government of India. TMC is affiliated to Homi Bhabha National Institute (HBNI). The HBNI is a Deemed University of the Department of Atomic Energy with a mission to develop high quality postgraduate educational programs in science and technology including those related to life and health sciences.

TMC invites applications from eligible candidates of Indian nationality, who are keen to pursue a career in TMC.

Translational Health Science and Technology Institute (THSTI) is an autonomous Institute of the Department of Biotechnology, Ministry of Science and Technology, Govt, of India. The institute is an integral part of the interdisciplinary NCR Biotech Science Cluster located at Faridabad, and is designed as a dynamic, interactive organization with the mission to conduct innovative translational research and to develop research collaborations across disciplines and professions to translate concepts into tangible products to improve human health.

Post : Research Associate

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ABOUT AUTHORS
R. Mishra¹, P. Barad¹, N. Patel², N. Patel³*
¹Department of Pharmacy,
Shree S.K. Patel College of  Pharmaceutical  Education & Research
Ganpat University, Kherva, Mehasana Gujarat
²Department of Pharmacognosy,
Shree S.K. Patel College of  Pharmaceutical  Education & Research
Ganpat University, Kherva, Mehasana Gujarat
³Department of Pharmacology,
Shree S.K. Patel College of  Pharmaceutical  Education & Research
Ganpat University, Kherva, Mehasana Gujarat

ABSTRACT
Worldwide cancer is the major cause of death. Almost 8.8 million people died due to different types of cancer such as lung cancer, liver cancer, breast cancer, stomach cancer, blood cancer etc. in 2015. Government of various countries and some private organizations are spending trillions dollars for the research in cancer.  According to report of WHO treatment cost of cancer is approximately US$ 1.16 trillion per year and this amount is increasing per year. Despite of huge work the exact cause of genesis is still unknown. Couples of therapies like chemotherapy, radiation, surgery and targeted therapy are available with some detrimental effect. Now scientists are seeking lead molecule from naturally occurring substances due to high safety margin as compared to current approaches. Natural phytochemicals are prominent strategy for prevention, treating, and curing cancer. There are many phytochemicals from herbs having potent anticancer property. Generally these phytochemicals treat cancer by different mechanisms like augmenting apoptosis, cell cycle arrest, targeting to some specific cancer inducing proteins, increasing cytotoxicity etc. This is our little attempt to gather information of phytochemicals having anticancer property such as Etoposide, Curcumin, Vincristine, etc. with postulated mechanism. Etoposide is effective in lung cancer, ovarian cancer by inhibiting type II Topoisomerase. Various research revealed that Curcumin is effective in different types of cancers by increasing apoptosis and targeting specific gene such as MDM2 oncogene is inhibited through the ETS2 transcription factor by modulation of signaling pathway PI3K/mTOR in breast cancer. Vincristine shows anticancer property by oncogenic EWS-FLI1 fusion protein inhibition which cause G2-M phase cell cycle arrest & reduce tumor. This review depicts few phytochemicals having anticancer property such as Etoposide, Curcumin, vincristine, etc. with possible mechanism.

CDRI is considered to be a pioneer research organization in the field of biomedical research where all the infrastructure and expertise are available to develop a drug right from its concept to market. The very latest techniques and methodologies are employed for developing drugs, diagnostics and vaccines to combat diseases prevalent among mankind in general and Indian population in particular. CDRI is a multidisciplinary research laboratory consisting of scientific personnel of various areas of biomedical sciences. For administrative and scientific purposes the Institute's manpower has been grouped into 17 R&D divisions and few divisions providing technical and scientific support.

Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna 800 007, a permanent Institute of Indian Council of Medical Research, Department of Health Research, Ministry of Health & Family Welfare, Govt. of India, invites online applications from suitable candidates for appointment on the Group A Scientific posts as mentioned below.

Teerthanker Mahaveer University is a Jain Minority State Private University established by Act No. 30 of 2008 of the Government of Uttar Pradesh and has been approved by University Grants Commission (UGC) under Section 2(f) of UGC Act, 1956. The university is located on National Highway-24 and is barely 144 Kms from National Capital, New Delhi. The University stand committed to the ideals of Lord Mahaveer i.e. Right Philosophy, Right Knowledge, and Right Conduct in all its operations and aspires to be recognized as an ultimate destination for world-class education.

Post : Professor / Associate Professor / Assistant Professor

Wipro Ltd is a global information technology, consulting and outsourcing company with services spanning financial services, retail, transportation, manufacturing, healthcare services, energy and utilities, technology, telecom and media.  Serving clients in 175+ cities across 6 continents, we help customers do business better by leveraging our industry-wide experience, deep technology expertise, comprehensive portfolio of services and vertically aligned business model. Our 55+ dedicated emerging technologies ‘Centers of Excellence’ enable us to harness the latest technology for delivering business capability to our clients. Wipro also champions optimised utilization of natural resources, capital and talent.

Post : Project Lead - Enterprise Platform Engineering