Skip to main content

March 2016

 

 

academics

 

Clinical research courses

FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS TO ENHANCE DISSOLUTION RATE OF LAMOTRIGINE BY USING SOLID DISPERSION TECHNIQUE

{ DOWNLOAD AS PDF }

ABOUT AUTHORS
Bhumi B. Patel1*, Chainesh N. Shah2, Rumit M. Shah3
1Department of Pharmaceutics, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh, Gujarat, India.
2 Department of Pharmacy, Sumandeep Vidyapeeth, Piparia, Gujarat, India
3 Department of Pharmacognosy, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh, Gujarat, India.
* patelbhumi198@gmail.com

ABSTRACT
Lamotrigine belongs to biopharmaceu­tical classification systems; BCS class II (Low solubility & High permeability). In addition, it requires immediate therapeutic action. Hence, the main objective of this study is to improve the solubility by solid dispersion technique and formulate it as Orodispersible tablets to avert the problems of swallowing and to provide rapid onset of action. Lamotrigine solid dispersion was prepared by using PEG 6000 as solubility enhancers and formulated it into ODT by direct compres­sion technique using different concentrations of Sodium Starch Glycolate, Cross Carmalose Sodium, and Kyron T-314 as cross linked polymers. The tablets were evaluated for various parameters and the results were found to be sat­isfactory. The batches batch containing Kyron T-314 as super disintegrant in 7% concentration, as they showed 95.75% drug release in 15 minutes with a disintegration time of 11 seconds which shows improved dissolution rate in compare to marketed formulation of Lamotrigine.

The Chilean health ministry has confirmed the first case of sexually transmitted Zika virus in the country, the media reported on Sunday.The 46-year-old woman was infected with the virus as she had unprotected sex with her partner, who was infected with Zika in Haiti, said the ministry on Saturday.

Pregnant women with higher blood levels of a common plastic chemical used in the coatings of food containers are more likely to deliver their babies early compared with women with lower levels of that chemical, says a study led by an Indian-origin researcher.

Aiming to slash the prevalence of violence-borne diarrhoea, the health ministry on Saturday launched the Rota Virus vaccine here, which will be available free of cost at public healthcare facilities, initially in four states.

We are often ignorant about loss of teeth but preserving oral health can benefit you in a longer run. According to researchers, loss of teeth is linked to increased risk for cognitive impairment and dementia in adults.

What has brain to do with glucose metabolism? A lot, say researchers, suggesting that not just your pancreas, a group of neurons in the hypothalamus area also plays a vital role in maintaining blood glucose levels.

(adsbygoogle = window.adsbygoogle || []).push({});

Asia's premier biopharmaceutical company, today announced that the Ministry of Health, Labour and Welfare (MHLW) of Japan has approved its biosimilar Insulin Glargine.  This is a significant achievement for Biocon and its commercial partner, FUJIFILM Pharma Co. Ltd (FFP) as it endorses our endeavor to bring high quality, yet affordable, world class products to diabetes patients in Japan.

Eli Lilly and Company announced that the U.S. Food and Drug Administration (FDA) has approved Taltz® (ixekizumab) injection 80 mg/mL for the treatment of moderate-to-severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy. Taltz should not be used in patients with a previous hypersensitivity reaction, such as anaphylaxis, to ixekizumab or to any of the excipients. Taltz is designed to specifically target IL-17A, a protein that plays a role in driving underlying inflammation in psoriasis.