February 2016

Lloyd is a best-in class, venture backed specialty therapeutic company focused on pharmaceuticals, Our initial focus is on products for Cardio vascular and supportive care, metabolic disorders and supportive care. Recently entering in Ortho-Gynaec segments

Quintiles is the only fully integrated biopharmaceutical services company offering clinical, commercial, consulting and capital solutions worldwide. Our network of 23,000 engaged professionals in 60 countries around the globe works with an unwavering commitment to patients, safety and ethics — ensuring a higher level of healthcare for people. For our biopharmaceutical customers, we help them navigate risk and seize opportunities in an environment where change is constant.

USAID(United States Agency For International Development )India is looking for an Experienced professonals Project Management Specialist (Monitoring, Evaluation and Learning), Development Assistance Specialist(Health Finance) and Project Management Specialist (HIV/AIDS). More information is available on website. last date of closing the receipt of job application is 17 February, 2016

Applications are invited for a temporary position of Junior Research Fellow (JRF) under the sponsored research project by Science and Engineering Research Board (Start-Up Research Grant-Young Scientists) on contract basis at, Department of Medicinal Chemistry, B. V. Patel PERD Centre, Ahmedabad,. as per following details:

ABOUT AUTHOR
Sonia Zaman
Department of Pharmacy,
Southeast University, Banani, Dhaka, Bangladesh
sonia_6995@yahoo.com

ABSTRACT
Garuga pinnata (family: Burseraceae) has many traditional medicinal uses including as astringent, bronchodilator, stomachic, expectorant, pulmonary infection, antidiabetic etc. The present study is based on this plant to evaluate the antimicrobial, antioxidant and cytotoxic properties of G. pinnata leaves. Antimicrobial activity of chloroform extract was evaluated against four Gram positive bacteria Bacillus megaterium, Bacillus subtilis, Sarcina lutea, Staphylococcus aureus and five Gram negative bacteria Escherichia coli, Pseudomonas aeruginosa, Salmonella paratyphi, Shigella dysentriae, Vibrio mimicus, and two common fungus Aspergillus niger, Candida albicans by applying disc diffusion method where Kanamycin disc (30 µg/disc) was used as reference standard. The chloroform extract of G. pinnata leaves showed very good antimicrobial activity against both gram positive and gram negative bacteria and fungus A. niger. The most susceptible microorganism was S. paratyphi (19 mm zone of inhibition) followed by B. subtilis (15 mm zone of inhibition). The antioxidant activity of chloroform extract of G. pinnata leaves was evaluated spectrophotometrically using 1,1-diphenyl-2-picrylhydrazyl (DPPH) for radical scavenging and  ascorbic acid was used as standard. The extract exhibited strong DPPH radical scavenging activity with IC₅₀ value of 57.06 µg/ml as compared to the IC₅₀ value of the reference standard, ascorbic acid (37.21 µg/ml). The cytotoxic activity of G. pinnata  was determined by brine shrimp lethality bioassay using vincristine sulfate as standard. The chloroform extract revealed significant cytotoxic activity with LC₅₀ of 6.607 µg/ml whereas LC₅₀ of Vincristine sulphate was 6.026 µg/ml.