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PharmaTutor (May- 2014)
ISSN: 2347 - 7881
Received On: 15/03/2014; Accepted On: 24/03/2014; Published On: 01/05/2014
Author: Mehul Kakdiya1*, Viral Kakdiya2, Darshan Madiya1
1Department of Quality Assurance,
Smt. R. D. Gardi B. Pharmacy College, Rajkot
2Pacific college of pharmacy, Udaipur, Rajasthan, India
*kakdiyamehul@gmail.com
ABSTRACT:
The present manuscript describes simple, sensitive, rapid, accurate, precise and economical Q-absorbance ratio method for the simultaneous determination of Paracetamol and Propyphenazone in their combined pharmaceutical dosage form. Absorbance ratio method uses the ratio of absorbance at two selected wavelengths, one which is an isoabsorptive point and other being the λ-max of one of the two components. Paracetamol and Propyphenazone show an isoabsorptive point at 264 nm in methanol.The second wavelength used is 249 nm, which is the λ-max of Paracetamol in methanol. The linearity was obtained in the concentration range of 1-12 μg/ml for Paracetamol and 5-24 μg/ml for Propyphenazone. The concentrations of the drugs were determined by using ratio of absorbance at isoabsorptive point and at the λ-max of Paracetamol. The method was successfully applied to pharmaceutical dosage form because of no interference. The results of analysis have been validated by recovery studies.
How to cite this article: MG Kakdiya, VM Kakdiya, D Madiya; Q-Absorbance Ratio Spectrophotometric Method for the Simultaneous Estimation of Paracetamol and Propyphenazone in their Combined Pharmaceutical Dosage Form; PharmaTutor; 2014; 2(5); 155-160
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REFERENCES:
1.Sweet man SC., The Martindale: The Complete Drug Reference; 36th Edn; Pharmaceutical Press, London, UK, 2009, pp 978.
2.Rang HP, Dale MM, Ritter JM and Moore PK, Pharmacology, 5th Edn; Elsevier, New Delhi 2006, pp 251,442.
3.Indian Pharmacopoeia, Volume 3, Ghaziabad: Govt. of Indian Ministry of Health and Family Welfare, the Controller of Publication, 2007, The Indian Pharmacopoeial Commission, pp 900-03.
4.British Pharmacopoeia, Volume I-II, London: The Department of Health,: HMSO Publication; 2009, pp 2789
5.The United States Pharmacopoeia-27, NF-22, Asian edition, Rockville, MD: The US Pharmacopoeial Convention, Inc., 2004, pp 1397-98.
6.Vichare V, Mujgond P, Tambe V and Dhole SN. Simultaneous Spectrophotometric determination of Paracetamol and Caffeine in Tablet formulation. International Journal of PharmTech Research, 2010, 2(4), 2512-2516.
7.Pawar PY, Joshi RS, Jangale KN and Wagh SK. Development and Validation of a Reversed Phase HPLC Method for Simultaneous Estimation of Enalapril maleate, Hydrochlorothiazide and Paracetamol in Pure and its Pharmaceutical Dosage Form. Pelagia Research Library, 2011, 2(5), 121-127.
8.Vyas AJ, Patel JK, Bhandari A, Chavda JR and Sheth NR. SimultaneousEstimation of Lornoxicam and Paracetmaol by Vierodt’s Method in APIand in Synthetic mixture. International Journal of ChemTech Research,2011, 3(3), 1269-1273.
9.ICH guideline Q2 (R1). Validation of analytical procedures: text and methodology. Geneva: 1996.
10.Beckett AH. And Stenlake JB. Practical Pharmaceutical Chemistry, part-II; 4th Edn; CBS Publisher and Distributors, New Delhi, 2007, pp 275-336
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