ABOUT AUTHORS:
Pankaj Verma*, Tapaswi Rani Dash
M.Pharm, Pharmaceutical Technology
Asst. Prof., Pharmaceutics, School of Pharmacy and Emerging Sciences, Solan
*pankaj.pharma23@gmail.com
ABSTRACT
Salbutamol sulphate (SS), a directly acting sympathomimetic drug, is a good candidate for controlled release formulations due to its short half-life of 1.6-3 h but it is quite challenging because of its high water solubility. The purpose of this research work is to design oral controlled-release matrix tablets of Salbutamol Sulphate using hydrophilic polymers, and thus increase patient compliance by reducing its frequency of administration. Salbutamol Sulphate matrix tablets are to be designed by direct compression method using HPMC K4M CR, HPMC K100M CR and Xanthan gum as various release retarding agents. These release rate retardents are used to control the drug release up to 24 h for administration as once daily dose. The compatibility of the drug with the various excipients is to be studied using FT-IR and DSC. The effects of polymer concentration, polymer viscosity and binary mixtures of some polymers on the in-vitro drug release are to be studied. Salbutamol Sulphate matrix tablets are used for the treatment of respiratory disorders like choronic asthma,bronchitis, bronchiolitis, chronic obstructive pulmonary disease (COPD) etc. . It possibly stimulates β-2 reseptors in lungs resulting in relaxation of smooth muscles by its β-2 agonist action.
