Monthly archive | PharmaTutor

15 April 2013

Walk in interview for the Post of Senior Research Fellow, Junior Research Fellow in Advanced Centre for Treatment, Research and Education in Cancer

The Advanced Centre for Treatment, Research and Education in Cancer (ACTREC) is the new state-of-the-art R&D satellite of the Tata Memorial Centre (TMC), which also includes under its umbrella the Tata Memorial Hospital (TMH), the largest cancer hospital in Asia. ACTREC has the mandate to function as a national centre for treatment, research and education in cancer. TMC is an autonomous grant-in-aid institution of the Department of Atomic Energy (DAE), Government of India.

15 April 2013

Senior Analytical Scientist II invited in Novartis Healthcare

A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.

15 April 2013

METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF AMLODIPINE AND INDAPAMIDE BY DIFFERENT SPECTROPHOTOMETRIC AND RP-HPLC METHODS IN BULK DRUG AND PHARMACEUTICAL FORMULATION

ABOUT AUTHORS:
Madhuri tadiparthi
Chalapathi institute of pharmaceutical sciences,
guntur, a.p, india.
tadiparthimadhuri@gmail.com

ABSTRACT:
Amlodipine (as besylate, mesylate or maleate) is a long-acting calcium channel blocker (dihydropyridine (DHP) class) used as an anti-hypertensive and in the treatment of angina. Indapamide is a thiazide diuretic used in the treatment of hypertension, as well as decompensated cardiac failure. Six new, simple, accurate and precise methods have been developed and validated according to ICH guidelines for the simultaneous estimation of Amlodipine and Indapamide in their combined dosage form (four UV-Spectrophotometric, one colorimetric and one RP-HPLC methods).
First method is based on simultaneous estimation using two wavelengths, 365 nm (λ_maxof AMLO) and 279 nm (λ_maxof INDA) by simultaneous equation method. The second method involves the use of first order derivative technique, here 293 nm, the zero crossing point of AMLO, 279 nm, the zero crossing point of INDA were used for the estimation. The third method is based on Q-absorption Ratio method using two wavelengths 365 nm (λ_maxof AMLO) and 312 nm (Isoabsorptive point). In the dual wavelength method two wave lengths 270 nm and 288 nm were selected as λ₁ and λ₂ for the estimation of AMLO, INDA shows the same absorbance at these wavelengths. Similarly, wavelengths 350 nm and 378 nm were selected as λ₁ and λ₂ for the estimation of INDA, AMLO shows the same absorbance at these wavelengths.Colorimetry: The method is based on use of MBTH reagent for simultaneous estimation of AMLO and INDA using two wavelengths, 626 nm (λ_maxof AMLO) and 600 nm (λ_maxof INDA).

15 April 2013

MICROBIAL TREATMENT OF OFFSET PRINTING INDUSTRY EFFLUENT

ABOUT AUTHORS:
Archana G. Kulkarni, R.S. Awasthi
Dept. of Microbiology, Shivaji Mahavidyalaya,
Renapur (M.S.)
*agnk.77@gmail.com

14 April 2013

Application are invited from Research Fellowships in Jamia Hamdard

14 April 2013

Indian institute of Chemical Biology invites Senior Project Fellow - walk in

14 April 2013

Job as Business Manager in Reputed pharma client of Nextus Solutions

Reputed pharma client of Nextus Solutions

Post: Business Manager

14 April 2013

DEVELOPMENT OF DOMPERIDONE NASAL GEL USING NATURAL MUCOADHESIVE AGENT OBTAINED FROM THE FRUITS OF DELLINIA INDICA. L.

About Authors:
Dharmendra Kumar*, BhanuPriya, S.K Gupta
*Department of Pharmaceutical Technology,
Meerut Institute of Engineering and Technology,
Meerut, Uttar Pradesh, India, 250005
*rvnimiet@gmail.com

Abstract.
The aim of this research work was replaced the tablet or injection of Domperidone by using domperidone nasal gel forrmulations. In research, day to day newer novel drug delivery comes for various drugs nasal gel drug delivery system one of them. Purpose of this study is formulating a nasal gel of Domperidone by using natural mucoadhesive agent extract from Dellinia Indica. In vitro drug release study carried out by using Franz-diffusion cell and excised bovine nasal membrane,characterisation was also found to be better in comparison to the HPMC and carbapolsynthetic polymers. Dellinia indica has valuable properties as a mucoadhesive agent because it is considered to be biocompatible, biodegradable and non-toxic. In future nasal gel formulations replace tablet/injection of Domperidone.

14 April 2013

DESIGN AND DEVELOPMENT OF COLON DRUG DELIVERY SYSTEM OF DICLOFENAC SODIUM

ABOUT AUTHORS:
A.Anil kumar, K.Surekha, M.Sujatha Kumari
Department of Pharmaceutics
Vikas college of pharmacy, Vissannapeta, 521215
*anilkumar.adi@gmail.com

ABSTRACT:
The objective of the present study of Diclofenac sodium was to treat inflammatory bowel disease in colon. Treatment for IBD is a long term therapy the colon drug delivery system of Diclofenac sodium to the colon provides the following benefits. Avoidance of first pass metabolism, to target local site. The tablet formulation of Diclofenac sodium provides time controlled release to treat the nocturnal symptoms of pain in colon. The formulation is administered in the night at 10 pm the action will be start early morning 3’0 clock Symptoms that are experienced in early morning hours should be avoided to maintain the lag period of drug release 5hrs. To maintain lag time the best method is pulsein cap drug delivery system and it is high expensive, poor in vivo correlation. Due to cost effectiveness and poor in vivo correlation we preferred to target colon as tablet dosage form. In the present study, the polymer selected as Guargum. Granules were prepared by wet granulation technique using Guargum in different ratios (drug: polymer) FG₁(1:0.25), FG₂(1:0.5), FG₃(1:0.75), FG₄(1:1), FG₅(1:1.25). To perform the interaction studies by IR spectra studies. To study the influence of polymer concentration on the Diclofenac sodium release from tablets. The prepared tablets were evaluated for different physical parameters and dissolutions studies were performed in 3 dissolution mediums like 0.1N hydrochloric acid for 2hr, pH 7.4 for 3hr, pH 6.8 up to 24hrs. Among all these formulations FG₄ formula (1:1) showed 98% up to 24 hrs drug release. The release mechanisms of all formulations are diffusion controlled conformed from higuchis plot, thus the present study concluded that drug and guar gum (1:1) ratio for fulfill to target local site for colon drug delivery system.