March 2013

The Indian Institute of Technology Madras (IITM ) is established as an autonomous instit ute of national importance in 1959 by the Government of India with an initial technical and financial support from Germany. IIT Madras with a number of well equipped laboratories, advanced research facilities, sophisticated services and computing and networking capabilities, is recognized to have done exceedingly well in the fields of higher technical education, research and industrial consultancy.

OREX PHARMA, one of the leading manufacturers and exporters of the active pharmaceutical ingredients and intermediates. Our head office at thane and plant at dombivli. We are ISO / GMP certified company and we will get our who approval by april end. We are in process of expansion and launching new products

Post: QC MANAGER

OREX PHARMA, one of the leading manufacturers and exporters of the active pharmaceutical ingredients and intermediates. Our head office at thane and plant at dombivli. We are ISO / GMP certified company and we will get our who approval by april end. We are in process of expansion and launching new products

Post: QA/RA MANAGER

Indian Institute of Pulses Research (IIPR) is a national institute established by the Indian Council of Agricultural Research (ICAR) to carry out basic strategic and applied research on major pulse crops.

OREX PHARMA, one of the leading manufacturers and exporters of the active pharmaceutical ingredients and intermediates. Our head office at thane and plant at dombivli. We are ISO / GMP certified company and we will get our who approval by april end. We are in process of expansion and launching new products

Post: Plant Manager

About Author
Manish kumar
Hindu College Of Pharmacy, Sonipat
*maggarwal0007@gmail.com

Abstract:
Dendrimers are perfect monodisperse macromolecules(poloymers) with regular and highly branched 3-D structure. Dendrimers have often been referred to as the “Polymer of the 21st century. They are characterized by branch upon branch architecture which are completely different from traditional Polymers. Exceptional feature of a dendrimer includes a high degree of structural symmetry, a density gradient displaying an intra-molecular minimum value and a well defined number of terminal groups. Dendrimers are normally used as carriers for drug delivery especially for oral, ocular and transdermal delivery. Oral drug delivery system are very important to the field of medicine, since most of the common illness are treated via oral route. Encapsulation and conjugation of drug with dendrimers have shown immerse employment for delivery of hydrophobic and labile drugs. Anticancer and antihypertensive drugs are most promising candidates for oral route using dendrimer as carrier. Dendrimers drug delivery system are therefore increasingly viewed as an advantageous for bioactive like drugs and gene. Although dendrimer drug delivery requires attention to certain manufacturing and biological consideration to be successful.

ABOUT AUTHORS
Ashwini Dhusiya, Ritu Mahajan,
Mahakal Inatitute of Pharmaceutical Studies, ujjain
Madhya Pradesh.
*ashwinidhusiya@gmail.com

ABSTRACT
Oncolytic virus is a wonderful discovery of 21^st century. The basic concept of Oncolytic virus was developed since 1946 but it was not produce its effect properly. Now latest technology and modern biotechnology introduce a very efficient Oncolytic virus. This is a genetically modified virus that can treat various type of cancer with fewer side effects than other treatment of cancer. It follows different mechanism of killing tumor by specifically replication; induction of tissue necrosis factor; activation of immunity and treat incurable cancer even in metastatic stage of cancer so it is also effective in leukemia. Oncolytic virus therapy is undergoing in clinical trial and shows better results.
This article covers brief knowledge of cancer, Virus and Oncolytic virus. It is helpful to understand history, mechanism, benefits and clinical data of Oncolytic virus. And a summary of marketed product ready to launch in near future.