January 2013

16 January 2013

DISCUSSION ON NOVEL VAGINAL DRUG DELIVERY SYSTEMS – A RECENT REVIEW

About Authors:
Lohithasu Duppala¹*, Anil kumar vadda²
¹GITAM Institute of Pharmacy, GITAM University, Pharmaceutics, visakhapatnam, Andhra Pradesh, India-530045.
²AVANTHI Institute of pharmaceutical sciences, pharmacology, visakhapatnam, Andhra Pradesh, India-530045.
¹lohithasu@gmail.com, ²anilkumar.vadda@gmail.com

INTRODUCTION:
Commonly, the olden days ,vaginal drug delivery systems are used to deliver vaginal infections treatment drugs and contraceptives.¹ The advantage of intra-vaginal controlled drug administration over conventional/traditional oral administration is the drug absorbed systemically because due to the presence of dense network of blood vessels in vaginal wall The vaginal cavity is also an effective site for the uterine targeting of various therapeutic agents such as terbutaline, progesterone and danazol.²But now-a-days ,the poorly absorbed oral drugs to be formulated as targeted vaginal drug delivery system to treat vaginal infections. In 1970, the first vaginal ring was used for delivery of medroxyprogesterone acetate for contraception.³ Vaginal drug delivery systems are traditionally used to deliver contraceptive and drugs to treat vaginal infections.

16 January 2013

REVIEW ON PROSTATE CANCER THERAPY

About Authors:
Kambham Venkateswarlu¹*, G.Sujatha²
¹Graduate Student
²Department of Pharmaceutical Chemistry
Sri Lakshmi Narasimha College of Pharmacy, Palluru,
Chittoor District, Andhra Pradesh-517132, India.
*k.v.reddy9441701016@gmail.com

I. INTRODUCTION
1.1. WHAT IS PROSTATE CANCER?
Prostate cancer is the most common type of cancer in men and is the second leading cause of cancer-related deaths in men worldwide. It is a disease of the prostate gland in which malignant cells form in the tissues of the prostate and multiply out of control. These cells often metastasize to other parts of the body, like the rectum, the bladder and especially, the bones and the lymph nodes. It generally arises near the surface of the gland so that it can be diagnosed easily by digital rectal examination (DRE). Depending on the extent of metastasis, the prostate cancer tissue has been graded using the Gleason System into a score of 2 to 10 or into four stages I-IV (or, A-D), indicating the likelihood of spreading of the disease to other parts of the body.

Although several types of cells are found in the prostate, over 99% of the cancers occur in the gland cells only (cells which make the prostate fluid which is added to the semen). Such type of cancer is termed as adenocarcinoma. The region of prostate gland where the adenocarcinoma is most common is the peripheral zone. Other types of cancer can also start in the prostate gland, including sarcomas (like leiomyosarcoma and rhabdomyosarcoma), small cell carcinomas, and transitional cell carcinomas, although they are extremely rare. Generally, the cancer grows and spreads very slowly. Early prostate cancer most often causes no symptoms. Sometimes, however there are signs and symptoms very close to those of benign prostatic hyperplasia (BPH).

15 January 2013

Opportunity for Analytical Scientist II in Novartis Healthcare

A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.

Post: Analytical Scientist II

15 January 2013

The Central Council for Research in Homoeopathy invites Consultant (Botany), Consultant (Chemistry), Data Entry Operator

The Central Council for Research in Homoeopathy (CCRH), an autonomous body under the Department of AYUSH, Ministry of Health and Family Welfare, Government of India intends to engage the following categories of personnel on contract basis for a period of 06 (six) months for Homoeopathic Pharmacopoeia Laboratory (HPL), Ghaziabad (Uttar Pradesh).

15 January 2013

BRUGADA SYNDROME: DIAGNOSIS, ORIGIN, RELATION WITH OTHER SYNDROMES

About Author:
Kambham venkateswarlu
Graduate student
Sri Lakshmi Narasimha College of Pharmacy, Palluru,
Chittoor District, Andhra Pradesh-517132, India.
k.v.reddy9441701016@gmail.com

ABSTRACT:
Brugada syndrome is a genetic cause of sudden cardiac arrest characterized by abnormal electrocardiographic (ECG) pattern in the right precordial leads either at rest or after provocation. In this condition, sudden death may occur due to polymorphic ventricular tachycardia or ventricular fibrillation. In approximately 30% of patients, sudden cardiac arrest is the initial clinical manifestation of Brugada syndrome.

15 January 2013

CROSSOVER DESIGNS AND BIOAVAILABILITY STUDY WITH STATISTICAL ANALYSIS: A REVIEW

About Authors:
Bhupender Kumar*, Prof. Sudeep Bhardwaj, Monish Sharma, Ramchandra
Seth G.L. Bihani S.D. College of Technical Education (Institute Of Pharmaceutical Sciences
And Drug Research), Sri Ganganagar, Rajasthan, 335001
*bhupendra.nimiwal@gmail.com

ABSTRACT:
In a typical crossover design, each subject takes each of the treatments under investigation on different occasions. Comparative bioavailability or bioequivalence studies, in which two or more formulations of the same drug are compared, are usually designed as crossover studies. Perhaps the greatest appeal of the crossover design is that each patient acts as his or her own control. This feature allows for the direct comparison of treatments, and is particularly efficient in the presence of large inter individual variation. However, caution should be used when considering this design in studies where carryover effects or other interactions are anticipated. Under these circumstances, a parallel design may be more appropriate.

14 January 2013

Vacancies for Ayush Pharmacist in NRHM Jharkhand | 42 Posts

Applications are invited for various vacancies in Health center/Zilla Hospital from Nation rural health mission in Jharkhand's 24 districs.

Post: Ayush Pharmacist

14 January 2013

Andhra Pradesh State AIDS Control Society invites Staff Nurse, Pharmacist, HIV Research Fellow (Non clinical) | 12 Posts

Applications are invited from qualified and suitable candidates to work at ART Centre in various districts of A.P. Interested Candidates can send their biodata duly specify the Name and Post applied, along with copies of their qualification and experience certificates to the address of Concerned Medical Superintendent, of the respective Hospitals (RIMS/District Hospital /Area Hospital/Government General Hospital.)

14 January 2013

Career for M.Pharm/M.Sc as Junior Research Fellow in DBT funded Project @ Assam University

Assam University came into existence through Assam (Central) University Act, 1989 (Act. No. XIII). It was established in 1994, since then the University is steadily becoming an excellent centre of learning. The campus, situated in Dargakona, about 20 kms from Silchar, is set amid sprawling hillocks, a typical landscape in the North East. The campus in an area of 600 acres surrounded by lakes and mountains provides an ideal environment for academic pursuit.

14 January 2013

BRUGADA SYNDROME: ETIOLOGY AND GENETICS, INCIDENCE, PATHOLOGICAL FINDINGS, CLINICAL MANIFESTATIONS

About Author:
Kambham Venkateswarlu
Graduate Student
Sri Lakshmi Narasimha College of Pharmacy,
Palluru, Chittoor District, Andhra Pradesh-517132, India.
k.v.reddy9441701016@gmail.com

ABSTRACT:
This is an inherited arrhythmia that causes the bottom chambers of the heart (the ventricles) to beat so fast that they can prevent the blood from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. While this is a disease that usually affects people in their 30's, it has actually been described at all ages. So it is important to screen everybody in a family. Not everybody who has the disease will have arrhythmias. However, we cannot know yet who will be OK and who will have problems. If you have had fainting spells related to Brugada syndrome, our experience indicates that you are at very high risk of having them again.