January 2013

About Author:
Dipak Kumar Dash
M Pharm pharmaceutics
Production officer -Akorn india pvt ltd
dipak.dipak.dash@gmail.com

INTRODUCTION
Introduction In recent years, polymeric controlled drug delivery systems have evolved as one of the most attractive areas in drug delivery research. The drug release is controlled by properties of the polymer-drug system and also by other factors like pH, enzymes etc. Despite several advantages offered by the controlled drug release, one important problem pertinent to the entire field is that all the systems so far developed give release rates that are constant or decrease with time.Increased delivery on demand will be very beneficial in situations like, delivery of insulin for patients with diabetes mellitus, antiarrythmics in case of heart disorders and nitrates in case of angina pectoris. This increased delivery on demand can be achieved by using external feed back control systems such as magnetic control. The concept of magnetically controlled drug delivery for the first time was proposed be Tyle in 1988. A system has been developed to magnetize the carriers so that these particles can be retained on the target site by the application of an external magnetic field of appropriate strength. Magnetic fields are believed to be harmless to biological systems and adaptable to any part of the body.

About Authors:
Narasimha Murthy Yedulapurapu*, Babu Rao. Chandu
Donbosco P.G. College of Pharmacy, 5th mile,
Pulladigunta, Kornepadu (V), vatticherukuru (M),
Guntur, Pin code: 522017, Andhra Pradesh.
*Murthyvedulapurapu@gmail.com

ABSTRACT:
Cefixime Trihydrate is an orally active third generation cephalosporin. It has plasma half-life of 3-4hrs; it is active against Gram+ve as well as Gram-ve bacteria. The present investigation involves the enhancement of dissolution rate of cefixime by using various solid dispersion techniques with a view to prolong the drug release in the gastrointestinal tract and consequently into the plasma. The solid dispersions were formulated by using the Croscarmelose sodium as a disintegrant. The solid dispersions were prepared by solvent evaporation, kneading, Physical mixing, Co-grinding techniques. In solvent evaporation technique, Dichloromethane is used as a solvent and in kneading technique water is used as solvent. The prepared solid dispersions were evaluated for in-vitro dissolution studies. Among the 5 formulations F5 sows the good results.