December 2012

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About Authors:
Patel Chirag J^*1, Prof. Satyanand Tyagi², Patel Pinkesh¹, Umesh Kumar¹, Patel Jaimin¹, Chaudhari Bharat^1
1Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
*Mr. Chirag Patel has published various Books, Research and Review articles. His academic works include 35 Publications (2 books was published in Lambert Academic Publishing, Germany & 8 Research Articles and 25 Review Articles was published in standard and reputed National and International Pharmacy journals)
²President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
*chirag.bangalore@gmail.com, +91-8000501871

ABSTRACT:
Aquasomes are spherical in shape with 60–300 nm particles size used for drug and antigen delivery. Aquasomes are nanoparticulate carrier systems but instead of being simple nanoparticles these are three layered self assembled structures, comprised of a solid phase nanocrystalline core coated with oligomeric film to which biochemically active molecules are adsorbed with or without modification. These structures are self assembled by non covalent and ionic bonds. The solid core provides the structural stability, while the carbohydrate coating protects against dehydration and stabilizes the biochemically active molecules. Properties like protection and preservation of fragile biological molecules, conformational integrity, and surface exposure made it as a successful carrier system for bioactive molecules like peptide, protein, hormones, antigens and genes to specific sites. Three types of core materials are mainly used for producing aquasomes: tin oxide, nanocrystalline carbon ceramics (diamonds) and brushite (calcium phosphate dihydrate). Calcium phosphate is the core of interest, owing to its natural presence in the body. Aquasome deliver their content through specific targeting and slow sustained release process.

About Authors:
Liladhar*
¹Seth G. L. Bihani S. D. College Of Technical Education,
Institute Of Pharmaceutical Sciences & Drug Research,
Gaganpath, Sri Ganganagar, Rajasthan 335001
ldbudania@gmail.com*

ABSTRACT:
The objective of the present research was to prepare fast disintegrating tablet of Seletracetam because of its application in epilepsy and convulsion related problem. Fast on set of action and avoidance of abundant of water in oral route. Which is highly desirable in this type of disease condition. The effect of formulation and process variables such as hardness, disintegration time, and in vitro dissolution and physical characteristics of fast dissolving tablet were examined on optimized drug/super disintegrant ratio by 32 factorial designs. During the work tablets were prepared by direct compression using Kyron T-314 and sodium starch Glycolate as super disintegrant ,where MCC,Lactose monohydrate for direct compression, aspartame as sweetner.The different powder blends were evaluated for pre-formulation parameters such as bulk density, tapped density, angle of repose,carr’s index,hausner’s ratio. The tablets were evaluated for post-compression parameters such as weight variation, Tablet hardness and tablet friability. In vitro Disintegration test, tablet thickness, in vitro dissolution profile. All the physical characteristics of powder blend and fibrillated tablet were within acceptable limits. The result of Dissolution studies indicated that formulation F7 release 98.70% of drug at 25 min interval which give the most successful of study.F7 batch contain Seletracetam (Drug), SSG(4%), kyron T-314(2%) and other excipients.F7 batch was the optimized batch since it showed of Disintegration time(17sec),friability(0.91%) and %Drug release (98.70%).

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