December 2012

The Kerala Public Service Commission is a body created by the Constitution of India.

Ajanta Medicals P. Ltd. is privately owned company established 30 years back at Mumbai. Company has acquired a reputation as a manufacturer of quality Ayurvedic products. The company has a distribution network in Mumbai, Gujarat and now willing to spread on pan India basis.

Post: Area Sales Manager

About Authors:
Roopesh Sachan^1*, Prof. Satyanand Tyagi², Tarun Parashar¹, Soniya¹, Patel Chirag J³, Patel Pinkesh³, Devesh Kaushik^4
1*Department of Pharmaceutics, Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-248007.
²President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
³Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
⁴Territory Business Manager, Diabetes Division, Abbott Healthcare Private Limited, Okhla, New Delhi, India- 110020.
*roopeshsachan@gmail.com, +91-9557469989, 9236167104

ABSTRACT:
In the world of pharmaceuticals, there is a vital role for robotics to play in the complicated processes of research and development, production, and packaging. Justification for robots ranges from improved worker safety to improved quality. Speeding up the drug discovery process is another benefit of robotics. Drug Production Robotics plays an important role in the manufacture of pharmaceutical drugs because, unlike other industries, pharmaceuticals demand higher speed and accuracy. Devices such as syringes, inhalers, IV bags and diabetes testing kits are made with the help of robotics. There is a great potential for the use of robotics systems in the pharmaceutical industry and pharmaceutical companies are gradually injecting more robotic systems into their operations.

About Authors:
Patel Chirag J^*1, Pinkesh Patel¹, Prof. Satyanand Tyagi², Tarun Parashar³, Soniya³, Roopesh Sachan³, Gaurav Singh^3
1Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020.
²President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074.
³Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, India-248007.
*chirag.bangalore@gmail.com, +91-8000501871

ABSTRACT:
Alzheimer's disease is a progressive neurologic disease of the brain leading to the irreversible loss of neurons and the loss of intellectual abilities, including memory and reasoning, which become severe enough to impede social or occupational functioning. Alzheimer's disease is also known as simply Alzheimer’s, and Senile Dementia of the Alzheimer Type (SDAT). During the course of the disease plaques and tangles develop within the structure of the brain. This causes brain cells to die. Patients with Alzheimer's also have a deficiency in the levels of some vital brain chemicals which are involved with the transmission of messages in the brain - neurotransmitters. Alzheimer's disease is the most common form of dementia. The disease gets worse as it develops - it is a progressive disease. There is no current cure for Alzheimer's, although there are ways of slowing down its advance and helping patients with some of the symptoms. Alzheimer's is also a terminal disease - it is incurable and causes death. According the National Institute on Aging, there are estimated to be between 2.4 million and 4.5 million Americans who have Alzheimer's. β-Secretase is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein contains two active site aspartate residues in its extra cellular protein domain and may function as a dimer.

Beta-secretase 1 (BACE1) also known as beta-site APP cleaving enzyme 1 (beta-site amyloid precursor protein cleaving enzyme 1), memapsin-2 (membrane-associated aspartic protease 2), and aspartyl protease 2 (ASP2) is an enzyme that in humans is encoded by the BACE1 gene.Beta-secretase 2 is an enzyme that in humans is encoded by the BACE2 gene. BACE2 is a close homolog of BACE1, a protease known to be an important enzyme involved in the cellular pathways that some believe lead to Alzheimer's disease. The aim of present article is to provide in depth knowledge about probable role of enzymes BACE1 and BACE2 in the management of Alzheimer's disease (AD). An attempt is also made to focus on general overview of Alzheimer’sdisease.

IITB, set up by an Act of Parliament, was established in 1958, at Powai, a northern suburb of Mumbai. Today the Institute is recognised as one of the centres of academic excellence in the country.

National Institute of Nutrition (NIN) was founded by Sir Robert McCarrison in the year 1918 as ‘Beri-Beri’ Enquiry Unit in a single room laboratory at the Pasteur Institute, Coonoor, Tamil Nadu. Within a short span of seven years, this unit blossomed into a "Deficiency Disease Enquiry" and later in 1928, emerged as full-fledged "Nutrition Research Laboratories" (NRL) with Dr. McCarrison as its first Director. It was shifted to Hyderabad in 1958.

Applications are invited for the position of Junior Research Fellow (JRF) in DBT sponsored project "Unravelling the cross talk between inflammation and apoptosis: Focusing on regulation of inflammatory mediators and apoptosis in cancer".

Post: Junior Research Fellow