April 2012

About Author:
K. Sravan Kumar*
Department of Pharmaceutics,
Seshachala College of Pharmacy,
Puttur-517 583, 
Chittoor (dist), A.P., India
*sravank681@gmail.com

Abstract:
In this study, transdermal patches containing Nimesulide were prepared using different ratios of polyvinylpyrrolidone (PVP) and Hydroxy propyl methyl cellulose (HPMC) by solvent evaporation technique using 10%w/w of dibutyl phthalate incorporated as plasticizer. The drug matrix film of PVP and HPMC was casted on a polyvinylalcohol backing membrane that was previously dried at 60⁰C for 6 hrs. All the prepared formulations were subjected to physical studies (moisture content, moisture uptake, Tensile strength, flatness and Drug content determination), in vitro release studies and in vitro skin permeation studies. The physiochemical compatibility of the drug and the polymers studied by IR spectroscopy have absence of any incompatibility. In vitro permeation studies were performed across  skin using a Franz diffusion cell. Variations in drug release profiles among the formulations studied were observed. Based on a physicochemical and in vitro skin permeation study, formulation F1 (PVP/HPMC, 5:1) and F5 (PVP/HPMC, 1:5) were chosen for further in vivo experiments. The anti inflammatory effect and a sustaining action of Nimesulide from the two transdermal patches selected were studied by inducing paw edema in rats with 1% w/v carrageenan solution. Hence, it can be reasonably concluded that Nimesulide can be formulated into the transdermal matrix type patches to sustain its release characteristics.

National Institute for Research in Reproductive Health (NIRRH), formerly known as Institute for Research in Reproduction is a premier research institute of the Indian Council of Medical Research (ICMR). It is situated in the vicinity of a number of hospitals and research institutes in central Mumbai. Since its inception in 1970, it has been making vigorous efforts to improve the reproductive health of people through research, education and health care services.

A State of the Art manufacturing facilities and has a strong position in the Softgel industry. Company's primary focus has been customizing drug delivery solutions for the healthcare industry.They have world class manufacturing facilities which have been accredited by U.K. MHRA, Australian TGA,WHO GMP, Ministry of Health viz. UAE, Jordan, Kenya, Malaysia, Iran, SriLanka, Vietnam, Thailand etc.), NAFDAC Nigeria & others and a packaging facility in Dubai Free Trade Zone.

AKS University is a private university in Satna, India established under an Madhya Pradesh state government act.
AKS University is the only private university in the Vindhya & Mahakoshal region and located at Sherganj, Satna, Madhya Pradesh. AKS University has been established under the Act of Government of Madhya Pradesh passed on November 2011

Kemtek (PTY) Ltd., an exciting Cosmetic Manufacturing company based in Francistown, Botswana.

Post: Manufacturing Chemist

Lupin Pharmaceuticals, Inc. is the U.S. wholly owned subsidiary of Lupin Limited, which is among the top six pharmaceutical companies in India. Through our sales and marketing headquarters in Baltimore, MD, Lupin Pharmaceuticals, Inc.

Religare Wellness (formerly, Fortis Healthworld) is a pioneering endeavor within India’s healthcare industry putting health solutions on the retail map. As a part of the vision of Fortis Healthcare and Religare Enterprises, Religare Wellness incorporates setting up of a Pan India World Class Retail Network of health stores that would provide comprehensive solutions under one roof.

B. M. Birla Heart Research Centre, Kolkata, India's 1st NABH accredited Hospital and also Certified by ISO 9001 - 2000,ISO 14001,OHSAS 18001 and NABL. B.M. Birla Heart Research Centre is committed to providing World Class Cardiac care to patients.The centre has performed a number of breakthroughs in Cardiac Surgery and Angioplasty. Now the ISO 9001 - 2008,ISO 14001:2004,OHSAS 18001:2007 and NABL Certification proves yet again that our persuits for the highest standards are directed towards Quality Heart Care.

About Authors:
Dinesh Kumar Jain*, Gajanan Darwhekar, Kapil Mahesh Dutt Swami
College of Pharmacy,
IPS Academy, Rajendra Nagar,
AB Road, Indore.
M.P. India.
*swamikpl@yahoo.com

ABSTRACT
Dandruff and seborrheic dermatitis are the common clinical conditions caused by increased growth of fungi and bacteria on the scalp which results in abnormal proliferation, scaling and flaking of scalp epidermis. In present study an attempt was made to develop hair styling gel of Fluconazole, zinc pyrithione and their combination using different concentration of carbopol 940. The formulations were evaluated and compare for rheology, pH, active content, in vitro drug release, ex vivo drug release, in vitro antidandruff activity and in vivo antidandruff activity. All the formulation are homogenous, transparent and stable but formulation HG1, HG7 and HG11 shows high clarity, optimum rheology, high drug content and  drug release, so these three formulations were evaluated for in vitro antidandruff activity. HG11 shows higher zone of inhibition then HG1 and HG7 therefore HG11 was selected for skin irritation test, in vivo study and stability study. HG11 does not show any skin irritation hence it could be an effective formulation for treatment of dandruff and seborrheic dermatitis as compare to other.