December 2011

12 December 2011

DESIGN AND IN-VITRO EVALUATION OF MOUTH DISSOLVING TABLETS OF ROSIGLITAZONE MALEATE BY USING NOVEL COPROCESSED SUPERDISINTEGRANTS

About Authors:
S.Pradeep kumar, D.Prathibha, Dr.N.L.Gowrishankar, R.Parthibarajan, L.Matsyagiri
Department of Pharmaceutics,
Swami Vivekananda Institute of Pharmaceutical Sciences,
Vangapally (V), Yadagirigutta (M), Nalgonda,
Andhra Pradesh, India.

ABSTRACT
The goal of the present investigation was to formulate and evaluate fast dissolving tablets (FDT) of Rosiglitazone maleate. To improve patient compliance, mouth dissolving tablets have emerged as an alternative to conventional dosage forms. Rosiglitazone and Sulfonylurea are given in combination for treatment of type 2Diabetes Mellitus for long term therapy. During this therapy, it is observed that there is uncontrolled increase of blood glucose level, andthe drug undergoes hepatic metabolism. Therefore, mouth dissolving tablets of Rosiglitazone were prepared to overcome this unusual problem and to make use of the inherent advantages of the novel drug delivery system.The tablets were prepared by using direct compression method using Superdisintegrants. Rosiglitazone mouth dissolving tablets containing Cross povidone & Cross carmellose sodium in the ratio 1:1 showed maximum drug release. Formulations were subjected to stability studies. Formulations are stable for 28 days at 40 oC / 75 % RH with insignificant change in the hardness, disintegration time and in vitro drug release pattern.

11 December 2011

Multiple Vacancies in Globela Pharma | Product Executives / Managers, Business Sales Executive, Area Business Manager, Regional Business Manager- 67 posts

GLOBELA PHARMA PVT LTD. is an ISO, FDCA – INDIA, WHO cGMP accredited company involved in manufacturing high quality Pharmaceutical Formulations. The company is managed by a team of highly qualified, experienced technocrats in R & D, Q.A. Q.C. and Production divisions.
The Company have two dedicated units and is well equipped with modern and sophisticated machineries as per guideline of FDCA – INDIA.

11 December 2011

GRAND OPENINGS FOR PHARMACISTS @ RUSHRAJ - Govt Posts - 1010 posts

Established under the Act Of State Government- “The Rajasthan University Of Health Sciences Act, 2005” (Act No. 1 of 2005)”on 25 day February, 2005, the University aims to disseminate and advance knowledge in medical and health sciences. The University provides academic and research facilities in various streams to the students studying in various Government Colleges (Medical, Dental, Nursing, Pharmacy & Paramedical) and private colleges/institutions affiliated to this University.

11 December 2011

Faculty Posts as SENIOR PROFESSORS, SENIOR LECTURERS & LECTURERS in Mangalayatan University

Mangalayatan University (MU) has been created under the "Mangalayatan University, Uttar Pradesh Act" and notified by the Government of Uttar Pradesh as Act No. 32 of 2006, by its Gazette No. 362/VII-V-1-1(Ka)-12/2006 dated October 30, 2006, with the right to confer degrees under section (2f) and 22(1) of the UGC Act. Established in 2006, MU was founded with the vision of providing high quality education to students that would equip them with skills to differentiate themselves in today’s fast changing world.

11 December 2011

Job in Mapra Labs as PERSONNEL EXECUTIVE - HR & Secretery

MAPRA came in inception in the year 1978 & after having a runaway success in eastern India, gradually expanding and now we are spreading our wings all over the country with great pace & getting a positive response for medical fraternity primarily because of high quality products.

11 December 2011

Gall Bladder Cancer as a “Silent Killer”

About Author: Rinki Verma (Research fellow)
Institute of Medical science (CEMS)
Banaras Hindu University
Varanasi - 221005

Abstract:
Gallbladder cancer is a comparatively rare cancer and has poor outcome due to their anatomy and location. It has peculiar geographical distribution being common in central and South America, central and eastern Europe, Japan and northern India; it is also common in certain ethnic groups e.g. Native American Indians and Hispanics (Kapoor VK, McMichael AJ ,2003. It is fifteen uncommon cancers in the world with high mortality rate. The diagnosis is made very late due to its silent course. The majority of patients have advanced disease at the time of presentation which carries a poor prognosis. The modes of spread of gall bladder carcinoma are direct, lymphatic, vascular, neural, intraperitoneal and intraductal. Ultra Sound, CT and MRI are helpful in diagnosis and staging of the disease. Surgery remains the mainstay of treatment and chemotherapy has a very limited role.

11 December 2011

Terminalia arjuna: Phytochemistry, pharmacognosy and pharmacological studies

About Author:
Amol.A.Dambal,
Department of Pharmacognosy and Phytochemistry
Govt. College of pharmacy, Kathora naka,
Amravati-444604. (M.S.), INDIA.

ABSTRACT:
The herbal remedies have been employed in various medical systems for the treatment and management of different diseases. The plant Terminalia arjuna has been used in different system of traditional medication for the treatment of diseases and ailments of human beings. The plants contain Arjunilic acid, Triterpine glycosides like Arjunetosides I, II, III, IV, Arjunine and Arjunetein. The bark is rich in Saponnins, natural anti-oxidants (flavonoids-arjunone,arjunolone,leteilin), gallic acid, ellagic acid , phytosterols, rich in minerals like ca, mg, zn and co, reducing sugars & coloring matter. It has been reported as Cardio tonic, Hepato-protective, Immunomodulatory, Antihyperglycemic, Antihyperlipidemic, Analgesic and Anti-Inflammatory, Antibacterial and Antiulcer properties.The current study is therefore carried out to provide requisite phytochemical and Pharmacological detail about the plant. The plant is cultivated in different parts of India on a small scale at present However; systematic information on different aspects of this species is not available. In this review, an attempt has been made to present this information.

11 December 2011

A Review on -A Rare Disorder of Waldenstrom’s Macroglobulinemia

About Authors:
Ms. Shilpa G. Lodha¹, Vanita Nimje², Ramzan Virani³
¹ Department of Biotechnology,
Agnihotri College of Science, Ram Nagar,
Wardha 442001, India.
² Department of Biotechnology,
Jankievi Bajaj college, Arvi Naka,
Wardha 442001, India.
³ Department of Biology,
Shivramji Moghe College of Science,
Panharkawada- 445 302, India.

Abstract
Many types of Cancer and Malingancy are known, in that Waldenstrom’s macroglobulinemia is rare cancer of an uncommon lymphoproliferative disorder characterized primarily by bone marrow infiltration and IgM monoclonal gammopathy. It should be considered a distinct clinicopathological entity rather than a clinical syndrome secondary to IgM secretion. The concentration of monoclonal IgM can vary widely in Waldenstrom’s macroglobulinemia and it is not possible to define a concentration that reliably distinguishes it from monoclonal gammopathy of undetermined significance (MGUS). Besides having lots of diagnosis method, there is no single accepted treatment for Waldenstrom’s macroglobulinemia. Commonly used treatment includes the monoclonal antibody rituximab, sometimes in combination with chemotherapeutic drugs such as chlorambucil, cyclophosphamide, or vincristine or with thalidomide. We have to find out the successful and low cost methods to cure Waldenstrom’s macroglobulinemia.

11 December 2011

PharmaQuiz- 28 | Find answers of PharmaQuiz - 27

ANSWERS of Previous PharmaQUIZ-27:

1.A 2.D 3.A 4.D 5.A

6.B 7.C 8.A 9.B 10.A

9 December 2011

Walk in Interview for Fresher Pharmacist in Indian Railways | Vacancies in North East Frontier Railway - 12 posts

ENGAGEMENT OF PARA-MEDICAL STAFF ON CONTRACT BASIS AGAINST VACANCIES EXISTING IN PARA -MEDICAL CATEGORY OF NORTHEAST FRONTIER RAILWAY, MALIGAON & ITS DIVISIONS– THROUGH WALK-IN INTERVIEW.