November 2011

Ranbaxy Laboratories Limited (Ranbaxy), India's largest pharmaceutical company, is an integrated, research based, international pharmaceutical company, producing a wide range of quality, affordable generic medicines, trusted by healthcare professionals and patients across geographies. Ranbaxy today has a presence in 23 of the top 25 pharmaceutical markets of the world. The Company has a global footprint in 46 countries, world-class manufacturing facilities in 7 countries and serves customers in over 125 countries.

Applications are invited for various positions in DBT sponsored research project “Potential for Carbon Sequestration in Grassland and Afforested Ecosystem using Molecular and Eddy Covariance Techniques”.

SIRO Clinpharm is one of the leading Global Clinical Research Organizations (CROs), offering full scope services conducting clinical trials in the Pharmaceutical, Biotechnology and Medical Devices sectors in compliance with International Standards. We are headquartered in India having global presence in USA, Israel and in Europe at Germany, Czech Republic, Greece, Estonia, Romania, Spain and France.

Flamingo Pharmaceuticals Ltd. is a quality driven pharmaceutical company with an experience of over two decades in global markets, exporting to 52 countries and having Rs.200 crores+ turnover. Flamingo has WHO-GMP/UK MHRA certified 100% EOU unit.

About Authors:
Sudhir Ghawade,
Vidyabharati college of pharmacy,
Amravati

Abstract:
In recent times, focus on plant research has increased all over the world.Caesalpinia crista (Caesalpiniaceae)plant is well known for its medicinal and therapeutic values in Indian Ayurveda.The Indian traditional scriptures as well as the Ayurvedic texts have various references to the use of this plant. The bitter principles Bonducin and Natin are the primary constituent of Caesalpinia crista apart from linolic acid, fatty acid, setasitosterol and different diterpenes  which mainly believed to be responsible for its wide therapeutic action. The plant has been recommended for the treatment of various diseases and disorders such as Antispasmodic, Malarial fever, leucorrhea, abdominal pain , rheumatoid, arthritis, diabetes,cystic fibrosis,  amenorrhoea. The herb is used both, internally as well as externally. The present review attempts to provide comphrensive information on pharmacology, phytochemical study,toxicity, traditional uses and current research prospects of the herb.

About Authors:
Singh khushboo, Sharma monica,
Ram gopal college of pharmacy,
Gurgaon

ABSTRACT
Approximately 40% of new drug candidate have poor water solubility and oral delivery of such drug is frequently associated with implications of low bioavailabilty,high inter and intra subject variability, lack of dose proportionality. Bioavalibilty of lipophilic drug can be solved by formation of self emulsifying drug delivery system.SEDDS are belongs to lipid formulation and size range is from 100nm[SEDDS] less than 50nm[SMEDDS] and contain a isotropic mixture of oil, surfactant and co surfactant which are emulsified in aqueous media under condition of gentle agitation. The theory behind dissolution rate improvement by means of SEDDS is the spontaneous development of emulsion in GIT with mild agitation provide by gastric motility, which present the drug in solubilized form,small size of formed droplet provided a large inter facial area for absorption,due to small globule size thAT can be easily absorb through lymphatic pathway, thereby passing hepatic pathway.

About Authors:
Prashant L. Pingale, Anjali P. Pingale  
Department of Pharmaceutics & Quality Assurance,
School of Pharmacy and Technology Management, NMIMS Shirpur Campus
Shirpur Dist: Dhule Maharashtra
INDIA 425405.

ABSTRACT:
Tablets or capsules taken orally remain one of the most effective means of treatment available. The effectiveness of such dosage forms relies on the drug dissolving in the fluids of the gastrointestinal tract prior to absorption into the systemic circulation. The rate of dissolution of the tablet or capsule is therefore crucial.
Drug release in the human body can be measured ‘in-vivo’ by measuring the plasma or urine concentrations in the subject concerned. However, there are certain obvious impracticalities involved in employing such techniques on a routine basis. These difficulties have led to the introduction of official ‘in-vitro’ tests which are now rigorously and comprehensively defined in the respective Pharmacopoeia.
Although initially developed for oral dosage forms, the role of the dissolution test has now been extended to ‘drug release’ studies on various other forms such as topical and transdermal systems and suppositories.