October 2011

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About Author: Shishir Tripathi
M.Pharm-Pharmaceutics
Department of Pharmacy,
Barkatullha University,
Bhopal-462026, M.P., India

Abstract
According to the Migraine Research Foundation, migraine ranks in the top 20 of the world’s most disabling medical illnesses with more than 10 percent of the population, including children, suffering from the migraine. Sumatriptan Succinate is a choice of drug used for the treatment of migraine when received at oral dose its bioavailability is approximately 14%. Considering the low bioavailability after oral and intranasal administration, due to presystemic metabolism and incomplete absorption as well as additional inconveniences associated with parenteral and oral administration, the exploitation of an alternative route of sumatriptan delivery, such as transdermal administration (topical gel)—could be sort out mentioned problem and enhance its therapeutic benefit up to most possible extent. Topical delivery systems of Sumatriptan succinate gel were formulated using polymers like HPMC, Carbopol 934 and Pectin and penetration enhancers like eucalyptus oil, menthol and oleic acid. The gels were evaluated for various parameters such as homogeneity, grittiness, extrudability, in vitro drug release, viscosity, pH, spreadability and drug content. The release rate of the gel was found to obey koresmeyer peppas kinetics. It can be concluded that HPMC gel has properties similar to marketed preparation and eucalyptus oil acts as a good penetration enhancer in Sumatriptan gels as compare to menthol and oleic acid.

About Author: Neeraj Kumar Garg*1, Pankaj Khatri1, Sangeeta Gupta2, N. Ganesh2
1. School of pharmacy, Suresh Gyan Vihar University, Mahal, Jagatpura, Jaipur (Raj.)
2. Incharge, Department of research, jawahar lal Nehru cancer Hospital and Research centre, Idgah hills Bhopal 462001 (M.P.)

Abstract
Alzheimer disease (AD) is a neurodegenerative disorder currently without an effective treatment. Impairment of memory is the initial and most significant symptom of Alzheimer disease (AD). The present study was under taken to investigate the effect of Selaginella bryopteris (popularly known as sanjeevani, Family: Selaginellaceae) on learning and memory. Two doses (250 and 500 mg/kg p.o.) of methanolic extract of Selaginella bryopteris were administered for 7 successive days in separate group of animals. The dose of 500 mg/kg p.o. of the methanolic extract of Selaginella bryopteris significantly improved learning and memory of mice. Antioxidant property of Selaginella bryopteris may be contributing favourably to the memory enhancement effect. However, further studies are necessitated to identify the exact mechanism of action. In the present investigation of Selaginella bryopteris have shown promising memory enhancing agent in the entire laboratory models employed.

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