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Estimation of Olmesartan Medoxomil and Atorvastatin Calcium in Tablet Dosage Form by HPLC Method
About Authors: Venkata Suresh Babu Aluri*
Department of pharmaceutical Analysis,
Adhiparasakthi College of Pharmacy,
Melmarvathur, Kancheepuram District, Tamil Nadu - 603319 (INDIA)
Reference ID: PHARMATUTOR-ART-1077
Abstract
A simple, specific, sensitive, rapid, precise and economical high performance liquid chromatography (HPLC) method has been developed for the estimation of Olmesartan medoxomil (OLM) and Atorvastatin calcium (ATC) in tablet dosage form by using acetonitrile- phosphate buffer pH 3.0 (40:60 v/v) as a solvent system. The method was carried out on a Phenomenex Gemini C18 (15 cm x 4.6 mm i.d., 5µm particle size) column, at flow rate 0.9 mL/min. Detection was carried out at 252 nm. The retention time of OLM and ATC was 3.19 and 4.63 min, respectively. The two drugs follow Beer-Lambert’s law over the concentration range of 8 – 40 µg/mL for OLM and 4 – 20 µg/mL for ATC. Validation of proposed method was carried out for its accuracy, precision, specificity and ruggedness according to ICH guidelines. The proposed method can be successfully applied in routine work for the determination of Olmesartan medoxomil and Atorvastatin calcium in combined dosage form.
Glenmark Pharmaceuticals today announced the settlement of litigation with Daiichi Sankyo and Genzyme Corporation regarding Glenmark's Abbreviated New Drug Application (ANDA) tiled with the US Food and Drug Administration (FDA) for Colesevelam Hydrochloride, a drug used in treatment of type-2 diabetes.
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