May 2011

About Authors: Biswajit Panda^1*, Abhinav Raoot¹, Vaishali Kilor¹, Nidhi Sapkal²
Dept of Pharmaceutics¹ and Dept of Pharmaceutical Chemistry²
Gurunanak College of Pharmacy, Nagpur

Reference ID: PHARMATUTOR-ART-1049

Abstract
Excipients are all substances contained in a dosage form other than the active substance. Tablets are the most commonly used dosage form because of the ease of manufacturing, convenience in administration, accurate dosing and stability compared to oral liquids and direct compression is the preferred method for the preparation of tablets because of several advantages. In order to justify the high rise in new drug development and high industrial output demand, new excipients with purpose satisfying characteristics are the need of the hour.New combinations of existing excipients are an interesting option for improving excipient functionality now-a-days. The current review article is prepared to have a look over the recent development in excipient technology and the approaches involved in development of such excipients. It signifies the synergistic outcome of the combination of excipients taking their material property into consideration. It also emphasises on the particular material properties in terms of physic-mechanical that are useful to overcome the limitation of existing excipients. All the developed co-processed excipients are enlisted highlighting their multi-functional and beneficial characteristics. Regulatory issues concerned with the development of new excipient are also discussed.

About Authors: Mrugank BP¹,  Mangala L²,  Hareesha RP³
Department(s) and institution(s)
1. National Institute of Pharmaceutical Education and Research (NIPER), Department of Pharmacy Practice, M.Pharm (Student)
2. Gauhati Medical College and Hospital (GMCH), Department of Pharmacology, Prof and Head; Chief academic co-ordinator, NIPER-Ghy.
3. National Institute of Pharmaceutical Education and Research (NIPER), Department of Pharmacy Practice, M.Pharm (Student)

Reference ID: PHARMATUTOR-ART-1048

Abstract:
Background: "Pharmacovigilance is the science and activity relating the detection, assessment, understanding and prevention of adverse effects or any other possible drug - related problems." ^[1]

Literature:Periodic safety update reports (PSUR)^[2]and Medical Dictionary for Regulatory Activities (MedDRA)^[3]are two important assets for maintenance of Drug safety Pharmacovigilancesystem as they are designed to represent the safety data on a particular drug from all the sources and geographical regions in the worldand to understand internationally, accepted clinically validated medical terminology for medical coding respectively.

About Authors: Bindi G. Chavda¹ ,Vipul P. Patel², Tushar R. Desai³,
1. Authour, R.K. College of Pharmacy, Kasturbadham, Rajkot.
2. Assistant professor (M.Pharm), R.K. College of Pharmacy, Kasturbadham, Rajkot.
3. Principal (Ph.D), Department of pharmacology, R.K. College of Pharmacy, Kasturbadham, Rajkot.

Reference ID: PHARMATUTOR-ART-1047

ABSTRACT
Chewing gums are mobile drug delivery systems. It is a potentially useful means of administering drugs either locally or systemically via, the oral cavity. The medicated chewing gum has through the years gained increasing acceptance as a drug delivery system. Several ingredients are now incorporated in medicated chewing gum, e.g. Fluoride for prophylaxis of dental caries, chlorhexidine as local disinfectant, nicotine for smoking cessation, aspirin as an analgesic, and caffeine as a stay alert preparation. In addition, a large number of chewing gum intended for prevention of caries, xerostomia alleviation, and vitamin/ mineral supplementation are currently available. Medicated chewing gums are solid, single dose preparations with a base consisting mainly of gums that are intended to be chewed but not swallowed. Today improved technology and extended know how have made it possible to develop and manufacture medicated chewing gum with predefined properties. Consequently today chewing gum is a convenient drug delivery system, which is appropriate for a wide range of active substances.

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