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  • Sex hormones modulate the immune system to influence disease risk differently

    Researchers have uncovered how hormones profoundly affect our immune systems, explaining why men and women are affected by diseases differently. 

    Scientists from the Karolinska Institutet in Sweden and Imperial College London have shown for the first time which aspects of our immune systems are regulated by sex hormones, and the impacts this has on disease risk and health outcomes in males and females.

  • Cognitive behavioral therapy enhances brain circuits to relieve depression

    A new study led by Stanford Medicine scientists found that certain changes in neural activity predicted which patients would benefit from a type of cognitive behavioral therapy.

    Cognitive behavioral therapy, one of the most common treatments for depression, can teach skills for coping with everyday troubles, reinforce healthy behaviors and counter negative thoughts. But can altering thoughts and behaviors lead to lasting changes in the brain?

  • GSK announces positive results from phase III trial of Nucala (mepolizumab) in COPD
    GSK plc announced positive headline results of MATINEE, the phase III clinical trial evaluating Nucala mepolizumab, a monoclonal antibody that targets interleukin-5 in adults with chronic obstructive pulmonary disease.
  • Mechanisms of how morphine relieves pain mapped out

    In a study published in Science, researchers at Karolinska Institutet describe the neural processes behind how morphine relieves pain. This is valuable knowledge because the drug has such serious side effects. 

    Morphine is a powerful painkiller that belongs to the group of opioids. It blocks signals in the pain pathways and also increases feelings of pleasure.  Morphine acts on several central and peripheral pain pathways in the body, but the neural processes behind the pain relief have not previously been fully understood.  

  • New findings on TB could change how we treat inflammatory disorders
    Tuberculosis is a confounding scourge. Its the leading cause of death from infectious disease in the world, and yet its estimated that those deaths represent perhaps 5% of infections with Mycobacterium tuberculosis.
  • Gut Bacteria Composition Influences Rotavirus Vaccine Efficacy

    Certain types of gut bacteria can hinder the efficacy of the rotavirus vaccine, according to researchers in the Institute for Biomedical Sciences at Georgia State University.

  • Drug delivery method can improve fungal infection treatment
    A unique method developed of drug delivery can prove useful to patients suffering from asthma, cystic fibrosis, or previous lung disease, human immunodeficiency virus HIV, cancer, or those exposed to corticosteroid medications for an extended duration.
  • Nasal spray flu vaccine candidate based on UW–Madison technology shows promise when administered alongside high dose annual shot

    A unique influenza vaccine candidate that’s inhaled and based on technology developed by University of Wisconsin–Madison researchers is safe and could bolster protection against seasonal and pandemic influenza for people vulnerable to severe disease when they receive it in addition to the annual flu shot.

  • Sleep resets neurons for new memories the next day
    Learning or experiencing new things activates neurons in the hippocampus, a region of the brain vital for memory. Later, while we sleep, those same neurons repeat the same pattern of activity, which is how the brain consolidates those memories that are then stored in a large area called the cortex.
  • Imfinzi granted Priority Review and Breakthrough Therapy Designation for patients with limited-stage small cell lung cancer in the US
    Food and Drug Administration grants Priority Review to applications for medicines that, if approved, would offer significant improvements over available options by demonstrating safety or efficacy improvements, preventing serious conditions or enhancing patient compliance.
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