Research News

- Read more about Asthma research unexpectedly yields new treatment approach for inherited enzyme disease
Experiments designed to reveal how a protein protects the lungs from asthma-related damage suggest a new way to treat a rare disease marked by the inability of cells to break down fats, according to a report in EBioMedicine published online
- Read more about ICGEB & Sun Pharma announce a new exclusive collaboration to develop novel dengue vaccine for India & Global markets
The ICGEB and Sun Pharmaceutical Industries announced their new collaboration for development of a dengue vaccine, targeted against all the four serotypes of Dengue virus that cause disease in humans. ICGEB has developed a tailored recombinant virus-like-particle (VLP) based tetravalent dengue vaccine, containing host-receptor binding domain of envelope protein of all the four DENV serotypes.
- Read more about ICGEB, Indian institute sheds light on immune response in Dengue
India has the highest numbers of dengue infections of any country. So far this year, over 51,730 cases of dengue cases have been reported in India, 2,333 in Delhi alone, but the actual estimated numbers might be ten times higher. Despite this emerging problem, there has been little work towards understanding the immune responses in Indians infected with the dengue virus.
- Read more about Novel cancer drug pass through blood-brain barrier
In efforts to develop new treatments for brain cancer, scientists from Johns Hopkins Drug Discovery and the Kimmel Cancer Center's Bloomberg~Kimmel Institute for Cancer Immunotherapy report they have altered the structure of an experimental drug that seems to enhance its ability to slip through the mostly impermeable blood-brain barrier.
- Read more about New formulation of ibuprofen may be superior for pain relief than the current version
Move over aspirin, a new formulation of ibuprofen might prove to be a "wonder drug." In a research report published online in The FASEB Journal, scientists used mice and rats to show that ibuprofen arginate may allow people to take higher doses without the cardiovascular side effects that are associated with current formulations found in over the counter products. In addition to being better tolerated, ibuprofen arginate also is released into the bloodstream more rapidly than the current formulations, likely providing faster pain relief.
- Read more about High cholesterol triggers mitochondrial oxidative stress leading to osteoarthritis
High cholesterol might harm more than our cardiovascular systems. New research using animal models, published online in The FASEB Journal, suggests that high cholesterol levels trigger mitochondrial oxidative stress on cartilage cells, causing them to die, and ultimately leading to the development of osteoarthritis. This research tested the potential therapeutic role of mitochondria targeting antioxidants in high-cholesterol-induced osteoarthritis and provided proof-of-concept for the use of mitochondrial targeting antioxidants to treat osteoarthritis.

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- Read more about Bioengineers' sweat sensor monitors glucose
Researchers at The University of Texas at Dallas are sweating the small stuff in their efforts to develop a wearable device that can monitor an individual's glucose level via perspiration on the skin.
- Read more about N-acetyl cysteine improves efficacy of adoptive T cell immunotherapy for melanoma
A collaborative team of investigators at the Medical University of South Carolina (MUSC) and Loyola University have demonstrated for the first time that culturing T cells in N-acetyl cysteine (NAC) before they are infused as immunotherapy improves effectiveness and outcomes in a preclinical model of melanoma.
- Read more about Triple-drug chemotherapy with topotecan helps preserve vision in retinoblastoma patients
St. Jude Children’s Research Hospital researchers report a topotecan-based chemotherapy regimen should be considered front-line therapy for patients with advanced bilateral retinoblastoma; an eye cancer in young children.
- Read more about Are natural alternatives to estrogen replacement therapy safe
Although individuals often consume natural products because of their potential health benefits, a new review indicates that it is not clear whether the benefits of plant-derived compounds that mimic estrogen outweigh the possible health risks. The findings are published in the British Journal of Pharmacology.