Solan

15 January 2014

AN INSIGHT TO IN-SITU GEL FORMING STOMACH SPECIFIC DRUG DELIVERY SYSTEM

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ABOUT AUTHORS:
Deepak Kumar*, Palak Kapoor
Shoolini University,
Solan, Himachal Pradesh
deepakkaushik354@gmail.com

ABSTRACT:
The oral delivery of drugs having narrow absorption window in the gastro-intestinal tract is limited by poor bioavailability with conventional dosage forms due to incomplete drug release and short residence time at the time of absorption. To provide controlled delivery of drugs novel drug delivery systems have been developed. Different systems have been developed to increase the gastric residence time viz. floating system, mucoadhesive, high density, expandable. Among all oral dosage forms, liquid orals are more prone to low bioavailability due to fast transit time from stomach to duodenum. Sustained/Controlled delivery can be achieved by decrease in the transit time of the dosage form. This can be augmented by an approach of liquid in-situ gelling system. These in-situ formulations are the drug delivery systems that are in sol form before administration in the body, but when administered, undergo gelation, in-situ, to form a gel. Formation of gel depends on various factors viz. temperature modulation, pH change, presence of ions, ultra-violet irradiation, from which drug releases in a sustained and controlled fashion. Different polymers which can be used for formation of in-situ gel include gellan gum, alginic acid, xyloglucan, pectin, chitosan, poly-caprolactone, poly-lactic acid, poly-lactic-co-glycolide. This article presents a detailed review of introduction, approaches to achieve in situ gelling system, polymers used, evaluation parameters, advantages of in situ gelling system.
19 August 2013

ALZHEIMER’S DISEASE Vs. DEMENTIA- A REVIEW

About Authors:
Ms. Kanika Soni, Ms. Pooja Dhiman*, Mr. Sandeep Singh
Chitkara University, Kalujhanda, Atal Shiksha Kunj,
Barotiwala, Solan [H.P], INDIA
*pooja.dhiman@chitkarauniversity.edu.in
30 July 2013

BARBITURATES – AN ABUSE

About Author:
Pooja Dhiman
Lecturer
Chitkara University, Solan [H.P]
Pooja.dhiman@chitkarauniversity.edu.in

The WHO defines drug abuse as “persistent or sporadic excessive drug use inconsistent with or unrelated to acceptable medical practice.” Barbiturates are the drugs which act on the central nervous system and produce depression.
2 July 2013

Work as PROFESSIONAL SERVICE REPRESENTATIVES, AREA MANAGER in Karnataka Antibiotics & Pharmaceuticals Ltd.

Karnataka Antibiotics & Pharmaceuticals Ltd., (KAPL) Bangalore is a Government Enterprise. From a modest beginning in 1984, KAPL has grown from strength to strength in the areas of manufacturing and marketing of various life saving and essential drugs. With an ISO accredition from KPMG, Netherlands, KAPL is recognised for its total commitment to quality and services in domestic and international markets. On profit from inception, KAPL facilities are approved by many international clients.
5 June 2013

THERAPEUTIC POTENTIAL OF VENOMOUS PEPTIDE IN VARIOUS DISEASES

ABOUT AUTHORS:
¹*Anjali Choba, ²Shikha Attri
¹M.Pharma in pharmacology from shoolini university solan, himachal pradesh
²M.Pharm in pharmaceutical chemistry from lachoo memorial college of science and technology, jodhpur
*anji5057@yahoo.in
28 April 2013

Wanted M.Pharm, M.Tech, M.Sc for the post of Research Scholars in JUIT

Applications are invited for the positions of Research Scholars in the Department of Biotechnology, Bioinformatics and Pharmaceutical Sciences. The research scholars will get an opportunity to work in the following areas under externally funded R&D projects worth Rs. 15.0 crores, including prestigious ones such as a DBT programme support under Centers of Excellence & Innovation in Biotechnology, DBT RGYI, DST-FIST, etc. in addition to DRDO, MoEF, ICMR funded.
4 October 2012

A REVIEW ON ALZHEIMER’S DISEASE WITH THEIR NEUROLOGICAL PATHWAYS PATHOPHYSIOLOGIC MECHANISMS & DRUG TREATMENT ON THEIR TARGET SITE

About Authors:
Ajay Kumar^*1, Dr. Bharat Prashar², Robin Sharma¹
¹M. Pharm (Pharmacology)
²Head of Pharmacy Department
Manav Bharti University, Solan.
*ajaykumarsharma423@hotmail.com

ABSTRACT
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, primarily manifesting as a loss of memory in old aged people. In this disease the destruction of neurons in the cortex and limbic structures of the CNS occurs, particularly in basal forebrain, amygdala, hippocampus, cerebral cortex. These areas are associated with functions of higher learning, memory, reasoning, behaviour, identification, an emotional control in brain. Alzheimer's disease is a devastating disease whose recent increase in incidence rates has broad implications for rising health care costs. Clinically, patients initially present with short-term memory loss, subsequently followed by executive dysfunction, confusion, agitation, and behavioural disturbances. This review comprises aspects of the introduction, history, types, etiology, pathophysiologic mechanisms of neurological pathways of Alzheimer’s disease and the drug treatments and their target site.
26 September 2012

INCIDENCE AND PREVENTION OF POSTOPERATIVE ADHESIONS

About Authors:
¹Robin Sharma*, ¹Ajay Kumar, ²Dr. Bharat Prashar
¹M.Pharm (Pharmacology)
²Head of Pharmacy Department
Manav Bharti University, Solan.
*sharmarobin@hotmail.com

ABSTRACT
Postoperative adhesions are a significant health problem with major implications on quality of life, health care and expenses on treatment. The purpose of this review was to investigate the incidence of post operative adhesions and the treatment measures such as efficacy of preventative techniques and adhesion barriers. The National Library of Medicine, Medline and A-Z databases were used to identify articles related to postoperative adhesions. Ileal pouch–anal anastomosis, open colectomy, and open gynecologic procedures are associated with the highest risk of adhesive small-bowel obstruction (class I evidence). Based on expert opinion (class III evidence) intraoperative preventative principles, such as meticulous haemostasis, avoiding excessive tissue dissection and ischemia, and reducing remaining surgical material such as powdered gloves have been published. Laparoscopic techniques, result in fewer adhesions than laparotomy techniques (class I evidence). Available bioabsorbable barriers, such as hyaluronic acid/carboxymethylcellulose, have been shown to reduce adhesions (class I evidence). Postoperative adhesions are a significant health problem after the surgery. General intraoperative preventative techniques, laparoscopic techniques, and the use of bioabsorbable mechanical barriers in the appropriate cases reduce the incidence and severity of peritoneal adhesions and post operative adhesions.

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6 September 2012

A REVIEW ARICLE ON SYNTHESIS AND BIOLOGICAL PROPERTY OF SOME NOVEL BUTENOLIDE DERIVATIVES

About Authors:
Rajender Kumar^1*,Dr.Sukhbir L.Khokara²,
¹Department of Pharmacy, Manav Bharti University, Solan (H.P.) 173229
²Institute of pharmaceutical sciences, Kurukshetra University,
Kurukshetra, Harayana-136119
*rajkaushal13@gmail.com

ABSTRACT
Butenolides (furanones) consist of unsaturated γ- lactone which occur in plants as glycosides. There is a group of steroids which contain α,β unsaturated butenolide ring in the side chain such steroids are known as cardenolides. The presence of γ - lactone ring contain natural products like Goniobutenolides A & B ,Digitoxigenin and lignans. These compound have biological properties like antibiotic, antitumor, anticonvulsant, antimicrobial and medicinal uses like fungicides, bactericides and allergic inhibitor.
18 August 2012

1st National Conference of Emerging Trend in Pharmaceuticals Sciences at Manav Bharti University | 29-30th sep 2012

Manav Bharti University established in 2009 under the H.P. Private University (Establishment & Regulation) Act, is owned by Manav Bharti Charitable Trust with the aim to advance and disseminate the knowledge and maintain highest standard of learning through teaching, research, extension education programme and conceptual aspects relevant to the need of the state. It is located in the rural backdrop of Himachal Pradesh and is equidistant (65 Km) from both Chandigarh and Shimla, 35 Km away from Kalka Railway Station, 6 Km away from NH 22 on Kumarhatti-Sultanpur Road (State Highway 6) at Laddo in District Solan. Serene and lush green picturesque surrounding makes the campus truly environment friendly, eloquent hustle free knowledge center.

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